PDB 3wym

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Overview

PDB Information

PDB	3WYM
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor. Kunitomo, J., Yoshikawa, M., Fushimi, M., Kawada, A., Quinn, J.F., Oki, H., Kokubo, H., Kondo, M., Nakashima, K., Kamiguchi, N., Suzuki, K., Kimura, H., Taniguchi, T. J.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2014-09-01
Resolution	2.000
CATH Insert Date	30 Nov, 2014

PDB Images (5)

Image of CATH 3wym

3wym

PDB 3wym

Image of CATH 3wymA

3wymA

PDB Chain 3wymA

Image of CATH 3wymB

3wymB

PDB Chain 3wymB

Image of CATH 3wymA00

3wymA00

CATH Domain 3wymA00

Image of CATH 3wymB00

3wymB00

CATH Domain 3wymB00

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	01 Dec, 2014	Chopped
B	01 Dec, 2014	Chopped

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
3wymA00	03 Dec, 2014	1.10.1300.10	Assigned
3wymB00	03 Dec, 2014	1.10.1300.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A