PDB 3skg

PDB Information

PDB3SKG
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.
Thompson, L.A., Shi, J., Decicco, C.P., Tebben, A.J., Olson, R.E., Boy, K.M., Guernon, J.M., Good, A.C., Liauw, A., Zheng, C., Copeland, R.A., Combs, A.P., Trainor, G.L., Camac, D.M., Muckelbauer, J.K., Lentz, K.A., Grace, J.E., Burton, C.R., Toyn, J.H., Barten, D.M., Marcinkeviciene, J., Meredith, J.E., Albright, C.F., Macor, J.E.
Bioorg.Med.Chem.Lett.
HeaderHydrolase/Hydrolase Inhibitor
Released2011-06-22
Resolution2.880
CATH Insert Date11 Sep, 2011

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 12 Sep, 2011 Chopped
B 12 Sep, 2011 Chopped
D 12 Sep, 2011 Chopped
E 12 Sep, 2011 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
3skgA01 16 Sep, 2011 2.40.70.10 Assigned
3skgA02 16 Sep, 2011 2.40.70.10 Assigned
3skgB01 16 Sep, 2011 2.40.70.10 Assigned
3skgB02 16 Sep, 2011 2.40.70.10 Assigned
3skgD01 15 Sep, 2011 2.40.70.10 Assigned
3skgD02 15 Sep, 2011 2.40.70.10 Assigned
3skgE01 16 Sep, 2011 2.40.70.10 Assigned
3skgE02 16 Sep, 2011 2.40.70.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1