PDB 3qaz

PDB Information

PDB3QAZ
MethodX-RAY DIFFRACTION
Host OrganismTrichoplusia ni
Gene SourceHomo sapiens
Primary Citation
Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
Levin, A.M., Bates, D.L., Ring, A.M., Krieg, C., Lin, J.T., Su, L., Moraga, I., Raeber, M.E., Bowman, G.R., Novick, P., Pande, V.S., Fathman, C.G., Boyman, O., Garcia, K.C.
Nature
HeaderSignaling Protein/Cytokine
Released2011-01-12
Resolution3.800
CATH Insert Date27 May, 2012

PDB Images (97)

PDB Prints

PDB Chains (36)

Chain ID Date inserted into CATH CATH Status
a 28 May, 2012 Chopped
A 28 May, 2012 Chopped
b 28 May, 2012 Chopped
B 28 May, 2012 Chopped
c 28 May, 2012 Chopped
C 28 May, 2012 Chopped
d 28 May, 2012 Chopped
D 28 May, 2012 Chopped
e 28 May, 2012 Chopped
E 28 May, 2012 Chopped
f 28 May, 2012 Chopped
F 28 May, 2012 Chopped
g 28 May, 2012 Chopped
G 28 May, 2012 Chopped
h 28 May, 2012 Chopped
H 28 May, 2012 Chopped
i 28 May, 2012 Chopped
I 28 May, 2012 Chopped
j 28 May, 2012 Chopped
J 28 May, 2012 Chopped
K 28 May, 2012 Chopped
L 28 May, 2012 Chopped
M 28 May, 2012 Chopped
N 28 May, 2012 Chopped
O 28 May, 2012 Chopped
P 28 May, 2012 Chopped
Q 28 May, 2012 Chopped
R 28 May, 2012 Chopped
S 28 May, 2012 Chopped
T 28 May, 2012 Chopped
U 28 May, 2012 Chopped
V 28 May, 2012 Chopped
W 28 May, 2012 Chopped
X 28 May, 2012 Chopped
Y 28 May, 2012 Chopped
Z 28 May, 2012 Chopped

CATH Domains (60)

Domain ID Date inserted into CATH Superfamily CATH Status
3qazA00 08 Jun, 2012 1.20.1250.10 Assigned
3qaza01 08 Jun, 2012 2.60.40.10 Assigned
3qaza02 08 Jun, 2012 2.60.40.10 Assigned
3qazb00 08 Jun, 2012 1.20.1250.10 Assigned
3qazB01 08 Jun, 2012 2.60.40.10 Assigned
3qazB02 08 Jun, 2012 2.60.40.10 Assigned
3qazc01 08 Jun, 2012 2.60.40.10 Assigned
3qazC01 08 Jun, 2012 2.60.40.10 Assigned
3qazc02 08 Jun, 2012 2.60.40.10 Assigned
3qazC02 08 Jun, 2012 2.60.40.10 Assigned
3qazD00 08 Jun, 2012 1.20.1250.10 Assigned
3qazd01 08 Jun, 2012 2.60.40.10 Assigned
3qazd02 08 Jun, 2012 2.60.40.10 Assigned
3qaze00 08 Jun, 2012 1.20.1250.10 Assigned
3qazE01 08 Jun, 2012 2.60.40.10 Assigned
3qazE02 08 Jun, 2012 2.60.40.10 Assigned
3qazf01 08 Jun, 2012 2.60.40.10 Assigned
3qazF01 08 Jun, 2012 2.60.40.10 Assigned
3qazf02 08 Jun, 2012 2.60.40.10 Assigned
3qazF02 08 Jun, 2012 2.60.40.10 Assigned
3qazG00 08 Jun, 2012 1.20.1250.10 Assigned
3qazg01 08 Jun, 2012 2.60.40.10 Assigned
3qazg02 08 Jun, 2012 2.60.40.10 Assigned
3qazh00 08 Jun, 2012 1.20.1250.10 Assigned
3qazH01 08 Jun, 2012 2.60.40.10 Assigned
3qazH02 08 Jun, 2012 2.60.40.10 Assigned
3qazi01 08 Jun, 2012 2.60.40.10 Assigned
3qazI01 08 Jun, 2012 2.60.40.10 Assigned
3qazi02 08 Jun, 2012 2.60.40.10 Assigned
3qazI02 08 Jun, 2012 2.60.40.10 Assigned
3qazJ00 08 Jun, 2012 1.20.1250.10 Assigned
3qazj01 08 Jun, 2012 2.60.40.10 Assigned
3qazj02 08 Jun, 2012 2.60.40.10 Assigned
3qazK01 08 Jun, 2012 2.60.40.10 Assigned
3qazK02 08 Jun, 2012 2.60.40.10 Assigned
3qazL01 08 Jun, 2012 2.60.40.10 Assigned
3qazL02 08 Jun, 2012 2.60.40.10 Assigned
3qazM00 08 Jun, 2012 1.20.1250.10 Assigned
3qazN01 08 Jun, 2012 2.60.40.10 Assigned
3qazN02 08 Jun, 2012 2.60.40.10 Assigned
3qazO01 08 Jun, 2012 2.60.40.10 Assigned
3qazO02 08 Jun, 2012 2.60.40.10 Assigned
3qazP00 08 Jun, 2012 1.20.1250.10 Assigned
3qazQ01 08 Jun, 2012 2.60.40.10 Assigned
3qazQ02 08 Jun, 2012 2.60.40.10 Assigned
3qazR01 08 Jun, 2012 2.60.40.10 Assigned
3qazR02 08 Jun, 2012 2.60.40.10 Assigned
3qazS00 08 Jun, 2012 1.20.1250.10 Assigned
3qazT01 08 Jun, 2012 2.60.40.10 Assigned
3qazT02 08 Jun, 2012 2.60.40.10 Assigned
3qazU01 08 Jun, 2012 2.60.40.10 Assigned
3qazU02 08 Jun, 2012 2.60.40.10 Assigned
3qazV00 08 Jun, 2012 1.20.1250.10 Assigned
3qazW01 08 Jun, 2012 2.60.40.10 Assigned
3qazW02 08 Jun, 2012 2.60.40.10 Assigned
3qazX01 08 Jun, 2012 2.60.40.10 Assigned
3qazX02 08 Jun, 2012 2.60.40.10 Assigned
3qazY00 08 Jun, 2012 1.20.1250.10 Assigned
3qazZ01 08 Jun, 2012 2.60.40.10 Assigned
3qazZ02 08 Jun, 2012 2.60.40.10 Assigned

UniProtKB Entries (36)

Accession Gene ID Taxon Description
P60568 IL2_HUMAN Homo sapiens Interleukin-2
P60568 IL2_HUMAN Homo sapiens Interleukin-2
P31785 IL2RG_HUMAN Homo sapiens Cytokine receptor common subunit gamma
P14784 IL2RB_HUMAN Homo sapiens Interleukin-2 receptor subunit beta
P14784 IL2RB_HUMAN Homo sapiens Interleukin-2 receptor subunit beta
P60568 IL2_HUMAN Homo sapiens Interleukin-2
P60568 IL2_HUMAN Homo sapiens Interleukin-2
P31785 IL2RG_HUMAN Homo sapiens Cytokine receptor common subunit gamma
P31785 IL2RG_HUMAN Homo sapiens Cytokine receptor common subunit gamma
P60568 IL2_HUMAN Homo sapiens Interleukin-2
P31785 IL2RG_HUMAN Homo sapiens Cytokine receptor common subunit gamma
P31785 IL2RG_HUMAN Homo sapiens Cytokine receptor common subunit gamma
P14784 IL2RB_HUMAN Homo sapiens Interleukin-2 receptor subunit beta
P14784 IL2RB_HUMAN Homo sapiens Interleukin-2 receptor subunit beta
P14784 IL2RB_HUMAN Homo sapiens Interleukin-2 receptor subunit beta
P60568 IL2_HUMAN Homo sapiens Interleukin-2
P60568 IL2_HUMAN Homo sapiens Interleukin-2
P60568 IL2_HUMAN Homo sapiens Interleukin-2
P60568 IL2_HUMAN Homo sapiens Interleukin-2
P31785 IL2RG_HUMAN Homo sapiens Cytokine receptor common subunit gamma
P31785 IL2RG_HUMAN Homo sapiens Cytokine receptor common subunit gamma
P14784 IL2RB_HUMAN Homo sapiens Interleukin-2 receptor subunit beta
P14784 IL2RB_HUMAN Homo sapiens Interleukin-2 receptor subunit beta
P60568 IL2_HUMAN Homo sapiens Interleukin-2
P31785 IL2RG_HUMAN Homo sapiens Cytokine receptor common subunit gamma
P31785 IL2RG_HUMAN Homo sapiens Cytokine receptor common subunit gamma
P14784 IL2RB_HUMAN Homo sapiens Interleukin-2 receptor subunit beta
P14784 IL2RB_HUMAN Homo sapiens Interleukin-2 receptor subunit beta
P14784 IL2RB_HUMAN Homo sapiens Interleukin-2 receptor subunit beta
P60568 IL2_HUMAN Homo sapiens Interleukin-2
P60568 IL2_HUMAN Homo sapiens Interleukin-2
P31785 IL2RG_HUMAN Homo sapiens Cytokine receptor common subunit gamma
P14784 IL2RB_HUMAN Homo sapiens Interleukin-2 receptor subunit beta
P31785 IL2RG_HUMAN Homo sapiens Cytokine receptor common subunit gamma
P31785 IL2RG_HUMAN Homo sapiens Cytokine receptor common subunit gamma
P14784 IL2RB_HUMAN Homo sapiens Interleukin-2 receptor subunit beta