PDB Information

PDB3M6F
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).
Watterson, S.H., Xiao, Z., Dodd, D.S., Tortolani, D.R., Vaccaro, W., Potin, D., Launay, M., Stetsko, D.K., Skala, S., Davis, P.M., Lee, D., Yang, X., McIntyre, K.W., Balimane, P., Patel, K., Yang, Z., Marathe, P., Kadiyala, P., Tebben, A.J., Sheriff, S., Chang, C.Y., Ziemba, T., Zhang, H., Chen, B.C., DelMonte, A.J., Aranibar, N., McKinnon, M., Barrish, J.C., Suchard, S.J., Murali Dhar, T.G.
J.Med.Chem.
HeaderCell Adhesion
Released2010-03-15
Resolution1.850
CATH Insert Date16 May, 2010

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 16 May, 2010 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
3m6fA00 28 Jul, 2010 3.40.50.410 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P20701 ITAL_HUMAN Homo sapiens Integrin alpha-L