PDB 3kmy

PDB Information

PDB3KMY
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel muM Leads for the Development of nM BACE-1 (beta-Site APP Cleaving Enzyme 1) Inhibitors.
Wang, Y.S., Strickland, C., Voigt, J.H., Kennedy, M.E., Beyer, B.M., Senior, M.M., Smith, E.M., Nechuta, T.L., Madison, V.S., Czarniecki, M., McKittrick, B.A., Stamford, A.W., Parker, E.M., Hunter, J.C., Greenlee, W.J., Wyss, D.F.
J.Med.Chem.
HeaderHydrolase
Released2009-11-11
Resolution1.900
CATH Insert Date21 Jan, 2010

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 22 Jan, 2010 Chopped
B 22 Jan, 2010 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
3kmyA01 13 Jun, 2010 2.40.70.10 Assigned
3kmyA02 13 Jun, 2010 2.40.70.10 Assigned
3kmyB01 13 Jun, 2010 2.40.70.10 Assigned
3kmyB02 13 Jun, 2010 2.40.70.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1