PDB 3gzn

PDB Information

PDB3GZN
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ.
Brownell, J.E., Sintchak, M.D., Gavin, J.M., Liao, H., Bruzzese, F.J., Bump, N.J., Soucy, T.A., Milhollen, M.A., Yang, X., Burkhardt, A.L., Ma, J., Loke, H.K., Lingaraj, T., Wu, D., Hamman, K.B., Spelman, J.J., Cullis, C.A., Langston, S.P., Vyskocil, S., Sells, T.B., Mallender, W.D., Visiers, I., Li, P., Claiborne, C.F., Rolfe, M., Bolen, J.B., Dick, L.R.
Mol.Cell
HeaderProtein Binding/Ligase
Released2009-04-07
Resolution3.000
CATH Insert Date07 Feb, 2010

PDB Images (19)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 08 Feb, 2010 Chopped
B 08 Feb, 2010 Chopped
C 08 Feb, 2010 Chopped
D 08 Feb, 2010 Chopped
I 08 Feb, 2010 Chopped
J 08 Feb, 2010 Chopped

CATH Domains (12)

Domain ID Date inserted into CATH Superfamily CATH Status
3gznA01 09 Feb, 2010 3.40.50.720 Assigned
3gznA02 09 Feb, 2010 Holding pen
3gznB01 10 Feb, 2010 3.40.50.720 Assigned
3gznB02 10 Feb, 2010 1.10.10.520 Assigned
3gznB03 10 Feb, 2010 3.10.20.260 Assigned
3gznC01 10 Feb, 2010 3.40.50.720 Assigned
3gznC02 10 Feb, 2010 Holding pen
3gznD01 09 Feb, 2010 3.40.50.720 Assigned
3gznD02 09 Feb, 2010 1.10.10.520 Assigned
3gznD03 09 Feb, 2010 3.10.20.260 Assigned
3gznI00 28 Aug, 2013 3.10.20.90 Assigned
3gznJ00 28 Aug, 2013 3.10.20.90 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
Q13564 ULA1_HUMAN Homo sapiens NEDD8-activating enzyme E1 regulatory subunit
Q8TBC4 UBA3_HUMAN Homo sapiens NEDD8-activating enzyme E1 catalytic subunit
Q8TBC4 UBA3_HUMAN Homo sapiens NEDD8-activating enzyme E1 catalytic subunit
Q13564 ULA1_HUMAN Homo sapiens NEDD8-activating enzyme E1 regulatory subunit
Q15843 NEDD8_HUMAN Homo sapiens NEDD8
Q15843 NEDD8_HUMAN Homo sapiens NEDD8