PDB Information

Host OrganismEscherichia coli
Gene SourceHuman immunodeficiency virus type 1
Primary Citation
Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses.
Tucker, T.J., Sisko, J.T., Tynebor, R.M., Williams, T.M., Felock, P.J., Flynn, J.A., Lai, M.T., Liang, Y., McGaughey, G., Liu, M., Miller, M., Moyer, G., Munshi, V., Perlow-Poehnelt, R., Prasad, S., Reid, J.C., Sanchez, R., Torrent, M., Vacca, J.P., Wan, B.L., Yan, Y.
CATH Insert Date16 Oct, 2008

PDB Images (12)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 16 Oct, 2008 Chopped
B 16 Oct, 2008 Chopped

CATH Domains (9)

Domain ID Date inserted into CATH Superfamily CATH Status
3drrA01 17 Oct, 2008 Assigned
3drrA02 17 Oct, 2008 Assigned
3drrA03 17 Oct, 2008 Assigned
3drrA04 17 Oct, 2008 Assigned
3drrA05 17 Oct, 2008 3.30.420.10 Assigned
3drrB01 17 Oct, 2008 Assigned
3drrB02 17 Oct, 2008 Assigned
3drrB03 17 Oct, 2008 Assigned
3drrB04 17 Oct, 2008 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P04585 POL_HV1H2 HIV-1 M:B_HXB2R Gag-Pol polyprotein
P04585 POL_HV1H2 HIV-1 M:B_HXB2R Gag-Pol polyprotein