PDB 3coh

PDB Information

PDB3COH
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability.
Rawson, T.E., Ruth, M., Blackwood, E., Burdick, D., Corson, L., Dotson, J., Drummond, J., Fields, C., Georges, G.J., Goller, B., Halladay, J., Hunsaker, T., Kleinheinz, T., Krell, H.W., Li, J., Liang, J., Limberg, A., McNutt, A., Moffat, J., Phillips, G., Ran, Y., Safina, B., Ultsch, M., Walker, L., Wiesmann, C., Zhang, B., Zhou, A., Zhu, B.Y., Ruger, P., Cochran, A.G.
J.Med.Chem.
HeaderTransferase
Released2008-03-28
Resolution2.700
CATH Insert Date19 Feb, 2009

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 19 Feb, 2009 Chopped
B 19 Feb, 2009 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
3cohA01 03 Mar, 2009 3.30.200.20 Assigned
3cohA02 03 Mar, 2009 1.10.510.10 Assigned
3cohB01 03 Mar, 2009 3.30.200.20 Assigned
3cohB02 03 Mar, 2009 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
O14965 AURKA_HUMAN Homo sapiens Aurora kinase A
O14965 AURKA_HUMAN Homo sapiens Aurora kinase A