PDB Information

PDB3CDE
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHepatitis C virus
Primary Citation
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.
Li, L.S., Zhou, Y., Murphy, D.E., Stankovic, N., Zhao, J., Dragovich, P.S., Bertolini, T., Sun, Z., Ayida, B., Tran, C.V., Ruebsam, F., Webber, S.E., Shah, A.M., Tsan, M., Showalter, R.E., Patel, R., Lebrun, L.A., Bartkowski, D.M., Nolan, T.G., Norris, D.A., Kamran, R., Brooks, J., Sergeeva, M.V., Kirkovsky, L., Zhao, Q., Kissinger, C.R.
Bioorg.Med.Chem.Lett.
HeaderTransferase
Released2008-02-26
Resolution2.100
CATH Insert Date05 Mar, 2009

PDB Images (11)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 05 Mar, 2009 Chopped
B 05 Mar, 2009 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
3cdeA01 03 Oct, 2013 Holding pen
3cdeA02 03 Oct, 2013 Holding pen
3cdeA03 03 Oct, 2013 3.30.70.270 Assigned
3cdeA04 03 Oct, 2013 Holding pen
3cdeB01 03 Oct, 2013 Holding pen
3cdeB02 03 Oct, 2013 Holding pen
3cdeB03 03 Oct, 2013 3.30.70.270 Assigned
3cdeB04 03 Oct, 2013 Holding pen

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P26663 POLG_HCVBK Hepatitis C virus (isolate BK) Genome polyprotein
P26663 POLG_HCVBK Hepatitis C virus (isolate BK) Genome polyprotein