Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.
Li, L.S., Zhou, Y., Murphy, D.E., Stankovic, N., Zhao, J., Dragovich, P.S., Bertolini, T., Sun, Z., Ayida, B., Tran, C.V., Ruebsam, F., Webber, S.E., Shah, A.M., Tsan, M., Showalter, R.E., Patel, R., Lebrun, L.A., Bartkowski, D.M., Nolan, T.G., Norris, D.A., Kamran, R., Brooks, J., Sergeeva, M.V., Kirkovsky, L., Zhao, Q., Kissinger, C.R.
Bioorg.Med.Chem.Lett.
