PDB 2xh5

PDB Information

PDB2XH5
MethodX-RAY DIFFRACTION
Host OrganismSPODOPTERA FRUGIPERDA
Gene SourceHOMO SAPIENS
Primary Citation
Discovery of 4-Amino-1-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Piperidine-4-Carboxamides as Selective, Orally Active Inhibitors of Protein Kinase B (Akt).
Mchardy, T., Caldwell, J.J., Cheung, K.M., Hunter, L.J., Taylor, K., Rowlands, M., Ruddle, R., Henley, A., De Haven Brandon, A., Valenti, M., Davies, T.G., Fazal, L., Seavers, L., Raynaud, F.I., Eccles, S.A., Aherne, G.W., Garrett, M.D., Collins, I.
J.Med.Chem.
HeaderTransferase
Released2010-06-09
Resolution2.720
CATH Insert Date20 Jun, 2010

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 20 Jun, 2010 Chopped
C 20 Jun, 2010 Rejected

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
2xh5A01 23 Jun, 2010 3.30.200.20 Assigned
2xh5A02 23 Jun, 2010 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P49841 GSK3B_HUMAN Homo sapiens Glycogen synthase kinase-3 beta
P31751 AKT2_HUMAN Homo sapiens RAC-beta serine/threonine-protein kinase