PDB 2oah

PDB Information

PDB2OAH
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation.
Stauffer, S.R., Stanton, M.G., Gregro, A.R., Steinbeiser, M.A., Shaffer, J.R., Nantermet, P.G., Barrow, J.C., Rittle, K.E., Collusi, D., Espeseth, A.S., Lai, M.T., Pietrak, B.L., Holloway, M.K., McGaughey, G.B., Munshi, S.K., Hochman, J.H., Simon, A.J., Selnick, H.G., Graham, S.L., Vacca, J.P.
Bioorg.Med.Chem.Lett.
HeaderHydrolase
Released2006-12-15
Resolution1.800
CATH Insert Date07 Nov, 2007

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 08 Nov, 2007 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
2oahA01 23 Nov, 2007 2.40.70.10 Assigned
2oahA02 23 Nov, 2007 2.40.70.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1