PDB 2fzz

PDB Information

PDB2FZZ
MethodX-RAY DIFFRACTION
Host Organism
Gene Source
Primary Citation
1-[3-Aminobenzisoxazol-5'-yl]-3-trifluoromethyl-6-[2'-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1']-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.
Pinto, D.J., Orwat, M.J., Quan, M.L., Han, Q., Galemmo, R.A., Amparo, E., Wells, B., Ellis, C., He, M.Y., Alexander, R.S., Rossi, K.A., Smallwood, A., Wong, P.C., Luettgen, J.M., Rendina, A.R., Knabb, R.M., Mersinger, L., Kettner, C., Bai, S., He, K., Wexler, R.R., Lam, P.Y.
Bioorg.Med.Chem.Lett.
HeaderHydrolase
Released2006-02-10
Resolution2.200
CATH Insert Date14 Jul, 2006

PDB Images (6)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 14 Jul, 2006 Chopped
L 14 Jul, 2006 Chopped

CATH Domains (3)

Domain ID Date inserted into CATH Superfamily CATH Status
2fzzA01 18 Oct, 2006 2.40.10.10 Assigned
2fzzA02 18 Oct, 2006 2.40.10.10 Assigned
2fzzL00 16 Oct, 2006 2.10.25.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P00742 FA10_HUMAN Homo sapiens Coagulation factor X
P00742 FA10_HUMAN Homo sapiens Coagulation factor X