PDB Information

Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases.
Coburn, C.A., Stachel, S.J., Li, Y.M., Rush, D.M., Steele, T.G., Chen-Dodson, E., Holloway, M.K., Xu, M., Huang, Q., Lai, M.T., DiMuzio, J., Crouthamel, M.C., Shi, X.P., Sardana, V., Chen, Z., Munshi, S., Kuo, L., Makara, G.M., Annis, D.A., Tadikonda, P.K., Nash, H.M., Vacca, J.P., Wang, T.
CATH Insert Date05 Mar, 2006

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 05 Mar, 2006 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
1tqfA01 05 Mar, 2006 Assigned
1tqfA02 05 Mar, 2006 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1