PDB 1sej

PDB Information

PDB1SEJ
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceCryptosporidium hominis
Primary Citation
Two crystal structures of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveal protein-ligand interactions including a structural basis for observed antifolate resistance.
Anderson, A.C.
Acta Crystallogr.,Sect.F
HeaderTransferase, Oxidoreductase
Released2004-02-17
Resolution2.870
CATH Insert Date05 Mar, 2006

PDB Images (21)

PDB Prints

PDB Chains (5)

Chain ID Date inserted into CATH CATH Status
A 05 Mar, 2006 Chopped
B 05 Mar, 2006 Chopped
C 05 Mar, 2006 Chopped
D 05 Mar, 2006 Chopped
E 05 Mar, 2006 Chopped

CATH Domains (15)

Domain ID Date inserted into CATH Superfamily CATH Status
1sejA01 09 Mar, 2006 3.40.430.10 Assigned
1sejA02 09 Mar, 2006 3.30.572.10 Assigned
1sejA03 09 Mar, 2006 3.30.572.10 Assigned
1sejB01 09 Mar, 2006 3.40.430.10 Assigned
1sejB02 09 Mar, 2006 3.30.572.10 Assigned
1sejB03 09 Mar, 2006 3.30.572.10 Assigned
1sejC01 09 Mar, 2006 3.40.430.10 Assigned
1sejC02 09 Mar, 2006 3.30.572.10 Assigned
1sejC03 09 Mar, 2006 3.30.572.10 Assigned
1sejD01 09 Mar, 2006 3.40.430.10 Assigned
1sejD02 09 Mar, 2006 3.30.572.10 Assigned
1sejD03 09 Mar, 2006 3.30.572.10 Assigned
1sejE01 09 Mar, 2006 3.40.430.10 Assigned
1sejE02 09 Mar, 2006 3.30.572.10 Assigned
1sejE03 09 Mar, 2006 3.30.572.10 Assigned

UniProtKB Entries (5)

Accession Gene ID Taxon Description
Q27552 Q27552_CRYPV Cryptosporidium parvum Bifunctional dihydrofolate reductase-thymidylate synthase
Q27552 Q27552_CRYPV Cryptosporidium parvum Bifunctional dihydrofolate reductase-thymidylate synthase
Q27552 Q27552_CRYPV Cryptosporidium parvum Bifunctional dihydrofolate reductase-thymidylate synthase
Q27552 Q27552_CRYPV Cryptosporidium parvum Bifunctional dihydrofolate reductase-thymidylate synthase
Q27552 Q27552_CRYPV Cryptosporidium parvum Bifunctional dihydrofolate reductase-thymidylate synthase