PDB 1sa4
PDB Information
| PDB | 1SA4 |
| Method | X-RAY DIFFRACTION |
| Host Organism | Escherichia coli |
| Gene Source | Homo sapiens |
| Primary Citation | Crystal Structures of the Anticancer Clinical Candidates R115777 (Tipifarnib) and BMS-214662 Complexed with Protein Farnesyltransferase Suggest a Mechanism of FTI Selectivity.
Biochemistry
|
| Header | Transferase |
| Released | 2004-02-06 |
| Resolution | 2.100 |
| CATH Insert Date | 05 Mar, 2006 |
PDB Prints
PDB Chains (2)
| Chain ID | Date inserted into CATH | CATH Status |
|---|---|---|
| A | 05 Mar, 2006 | Chopped |
| B | 05 Mar, 2006 | Chopped |
CATH Domains (2)
| Domain ID | Date inserted into CATH | Superfamily | CATH Status |
|---|---|---|---|
| 1sa4A00 | 05 Mar, 2006 | 1.25.40.120 | Assigned |
| 1sa4B00 | 05 Mar, 2006 | 1.50.10.20 | Assigned |
UniProtKB Entries (2)
| Accession | Gene ID | Taxon | Description |
|---|---|---|---|
| P49354 | FNTA_HUMAN | Homo sapiens | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
| P49356 | FNTB_HUMAN | Homo sapiens | Protein farnesyltransferase subunit beta |
