PDB Information

PDB1JU6
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.
Sayre, P.H., Finer-Moore, J.S., Fritz, T.A., Biermann, D., Gates, S.B., MacKellar, W.C., Patel, V.F., Stroud, R.M.
J.Mol.Biol.
HeaderTransferase
Released2001-08-23
Resolution2.890
CATH Insert Date05 Mar, 2006

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 05 Mar, 2006 Chopped
B 05 Mar, 2006 Chopped
C 05 Mar, 2006 Chopped
D 05 Mar, 2006 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
1ju6A00 05 Mar, 2006 3.30.572.10 Assigned
1ju6B00 05 Mar, 2006 3.30.572.10 Assigned
1ju6C00 05 Mar, 2006 3.30.572.10 Assigned
1ju6D00 05 Mar, 2006 3.30.572.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P04818 TYSY_HUMAN Homo sapiens Thymidylate synthase
P04818 TYSY_HUMAN Homo sapiens Thymidylate synthase
P04818 TYSY_HUMAN Homo sapiens Thymidylate synthase
P04818 TYSY_HUMAN Homo sapiens Thymidylate synthase