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CATH Superfamily 1.20.1250.90

Thymic stromal lymphopoietin

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Thymic stromal lymphopoietin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Thymic stromal lymphopoietin

Structural domains that comprise this superfamily share the structure of the a pro-allergic, IL-7-like hematopoietic, cytokine thymic stromal lymphopoietin (TSLP), key in the development of widespread chronic inflammatory disorders such as asthma and atopic dermatitis. This domain is annotated on InterPro to mainly function on myeloid cells, causing their proliferation and may promote inflammatory responses by directly activating mast cells.

GO Diversity

Unique GO annotations
24 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
55 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 6
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 6
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 3
Function
Unique EC:
Unique GO: 24
Taxonomy
Unique Species: 55