Table of Contents
Corin Yeats
Gene3D and BioMiner
Gene3D: Design and development, HMM library construction and prediction verification, and web services.
Academic Background
PhD at the Sanger Institute (2004), supervised by Alex Bateman (Pfam).
Thesis: Biological Investigations Through Sequence Analysis.
Currently a PostDoc at UCL.
Current Research Interests
All things domain, and plenty of evolution; function prediction for when I'm feeling pragmatic. I prefer to tie function to specific physical features, and am interested in understanding how we can predict emergent functions from the combinations of active elements within a protein. My feeling is that function prediction through statistical identification of correlated terms or similarity matches and path reconstruction will never be truly predictive, but can only infer functional associations based on prior observation. As a result they will always generate substantial numbers of errors.
Selected Publications
For a full list of my publications follow this link:
http://www.ncbi.nlm.nih.gov/pubmed?term=%28Yeats+C[au]%29+OR+%28Yeats+CA[au]%29
Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei.
Bentley SD, Maiwald M, Murphy LD, Pallen MJ, Yeats CA, Dover LG, Norbertczak HT, Besra GS, Quail MA, Harris DE, von Herbay A, Goble A, Rutter S, Squares R, Squares S, Barrell BG, Parkhill J, Relman DA
Lancet361p637-44(2003 Feb 22)
Bentley SD, Maiwald M, Murphy LD, Pallen MJ, Yeats CA, Dover LG, Norbertczak HT, Besra GS, Quail MA, Harris DE, von Herbay A, Goble A, Rutter S, Squares R, Squares S, Barrell BG, Parkhill J, Relman DA
Lancet361p637-44(2003 Feb 22)
Genome of the host-cell transforming parasite Theileria annulata compared with T. parva.
Pain A, Renauld H, Berriman M, Murphy L, Yeats CA, Weir W, Kerhornou A, Aslett M, Bishop R, Bouchier C, Cochet M, Coulson RM, Cronin A, de Villiers EP, Fraser A, Fosker N, Gardner M, Goble A, Griffiths-Jones S, Harris DE, Katzer F, Larke N, Lord A, Maser P, McKellar S, Mooney P, Morton F, Nene V, O'Neil S, Price C, Quail MA, Rabbinowitsch E, Rawlings ND, Rutter S, Saunders D, Seeger K, Shah T, Squares R, Squares S, Tivey A, Walker AR, Woodward J, Dobbelaere DA, Langsley G, Rajandream MA, McKeever D, Shiels B, Tait A, Barrell B, Hall N
Science309p131-3(2005 Jul 1)
Pain A, Renauld H, Berriman M, Murphy L, Yeats CA, Weir W, Kerhornou A, Aslett M, Bishop R, Bouchier C, Cochet M, Coulson RM, Cronin A, de Villiers EP, Fraser A, Fosker N, Gardner M, Goble A, Griffiths-Jones S, Harris DE, Katzer F, Larke N, Lord A, Maser P, McKellar S, Mooney P, Morton F, Nene V, O'Neil S, Price C, Quail MA, Rabbinowitsch E, Rawlings ND, Rutter S, Saunders D, Seeger K, Shah T, Squares R, Squares S, Tivey A, Walker AR, Woodward J, Dobbelaere DA, Langsley G, Rajandream MA, McKeever D, Shiels B, Tait A, Barrell B, Hall N
Science309p131-3(2005 Jul 1)
Predicting protein function with hierarchical phylogenetic profiles: the Gene3D Phylo-Tuner method applied to eukaryotic genomes.
Ranea JA, Yeats C, Grant A, Orengo CA
PLoS Comput Biol3pe237(2007 Nov)
Ranea JA, Yeats C, Grant A, Orengo CA
PLoS Comput Biol3pe237(2007 Nov)
The PASTA domain: a beta-lactam-binding domain.
Yeats C, Finn RD, Bateman A
Trends Biochem Sci27p438(2002 Sep)
Yeats C, Finn RD, Bateman A
Trends Biochem Sci27p438(2002 Sep)
Gene3D: comprehensive structural and functional annotation of genomes.
Yeats C, Lees J, Reid A, Kellam P, Martin N, Liu X, Orengo C
Nucleic Acids Res36pD414-8(2008 Jan)
Yeats C, Lees J, Reid A, Kellam P, Martin N, Liu X, Orengo C
Nucleic Acids Res36pD414-8(2008 Jan)
The implications of alternative splicing in the ENCODE protein complement.
Tress ML, Martelli PL, Frankish A, Reeves GA, Wesselink JJ, Yeats C, Olason PL, Albrecht M, Hegyi H, Giorgetti A, Raimondo D, Lagarde J, Laskowski RA, López G, Sadowski MI, Watson JD, Fariselli P, Rossi I, Nagy A, Kai W, Størling Z, Orsini M, Assenov Y, Blankenburg H, Huthmacher C, Ramírez F, Schlicker A, Denoeud F, Jones P, Kerrien S, Orchard S, Antonarakis SE, Reymond A, Birney E, Brunak S, Casadio R, Guigo R, Harrow J, Hermjakob H, Jones DT, Lengauer T, Orengo CA, Patthy L, Thornton JM, Tramontano A, Valencia A
Proc Natl Acad Sci U S A104p5495-500(2007 Mar 27)
Tress ML, Martelli PL, Frankish A, Reeves GA, Wesselink JJ, Yeats C, Olason PL, Albrecht M, Hegyi H, Giorgetti A, Raimondo D, Lagarde J, Laskowski RA, López G, Sadowski MI, Watson JD, Fariselli P, Rossi I, Nagy A, Kai W, Størling Z, Orsini M, Assenov Y, Blankenburg H, Huthmacher C, Ramírez F, Schlicker A, Denoeud F, Jones P, Kerrien S, Orchard S, Antonarakis SE, Reymond A, Birney E, Brunak S, Casadio R, Guigo R, Harrow J, Hermjakob H, Jones DT, Lengauer T, Orengo CA, Patthy L, Thornton JM, Tramontano A, Valencia A
Proc Natl Acad Sci U S A104p5495-500(2007 Mar 27)
The Pfam protein families database.
Bateman A, Coin L, Durbin R, Finn RD, Hollich V, Griffiths-Jones S, Khanna A, Marshall M, Moxon S, Sonnhammer EL, Studholme DJ, Yeats C, Eddy SR
Nucleic Acids Res32pD138-41(2004 Jan 1)
Bateman A, Coin L, Durbin R, Finn RD, Hollich V, Griffiths-Jones S, Khanna A, Marshall M, Moxon S, Sonnhammer EL, Studholme DJ, Yeats C, Eddy SR
Nucleic Acids Res32pD138-41(2004 Jan 1)
Links
Other CATH Team Members
| Person | Description |
|---|---|
| benoit | Post-Doctoral Research Associate I work on the analysis of protein structures and functions and how these relate to one another in evolution. Research Interests My main research interests are the evolution of protein structure and function, and how structural changes can result in functional changes in proteins. |
| clegg | [Andrew with a half-metre sausage, found (and eaten) on holiday in Germany recently] Senior Research Associate, CATH Development A member of the Orengo group in June 2008, I am the technical lead on the FuncNet platform, which brings together an ensemble of protein function analysis tools from various groups around Europe. This work is supported by the EU-funded EMBRACE and ENFIN research networks. |
| cuff | [ Me and my Cat] CATH Manager I am responsible for the general management and manual curation of CATH. Academic Background As a undergraduate, I read for a BSc(Hons) degree in Biomedical Sciences at the University of Durham and then, after deciding I wanted to pursue Bioinformatics research, I took a MSc degree in Information Technology at the University of Teesside (this was all back in the days before MSc courses in Bioinformatics became available!). |
| lee | [ ] Post Doctoral Research Fellow I work for the Midwest Center for Structural Genomics (MCSG). My responsibilities include selecting protein targets for structure determination, monitoring the success of target selection strategies, and providing homology models of relatives of MCSG structures. |
| lees | Gene3D Since arriving in October 06 I've been doing development of the Gene3D database in collaboration with Corin Yeats. I also maintain the current Gene3D website. I am involved in several collaborations with experimentalists. Recently (June 2009) I have started a new post employed by ENFIN coordinating a chromosome condensation prediction project, with Juan Ranea (Malaga) and the Ellenberg group (EMBL) (amongst others). We are using novel high throughput phenotype data (Ellenberg Group) … |
| lewis | [Me in Malaysia] Senior Programmer I was heavily involved in the complete rewrite of the CATH update procedure that culminated in CATH v3.0.0. I am still involved in maintaining and developing CATH in an ongoing consultancy capacity. Academic Background MSc Intelligent Systems, UCL (2002-2003) |
| orengo | See departmental staff page |
| perkins | [Me] London Pain Consortium PhD Student I am a member of the London Pain Consortium, an initiative formed in 2002 by a grant from the Wellcome Trust. I am currently moving into the first year proper of my PhD, supervised by Christine and based in the CATH lab, having completed a year of 3 rotations, working on projects with different labs. |
| phil | [Me] Role in CATH I am post doctoral research associate. One of my responsibilities is the target selection database for the Center for Structural Genomics of Infectious Diseases's structural genomics project. Research Interests CSGID applies state-of-the-art high-throughput structural biology technologies to experimentally characterise the three dimensional atomic structure of targeted proteins from pathogens in the NIAID Category A-C priority lists and organisms causing emerging and re-… |
| redfern | [Posing on the southbank of the Thames] Post-Doctoral Research fellow I work as part of the Midwest Consortium for Structural Genomics, aiding target selection and analysis of the novelty of the protein structures they produce. In parallel, I also develop methods for homology recognition and function prediction from protein structure and sequence. |
| reid | [Me enjoying a traditional Japanese kaiseki meal in a ryokan somewhere outside Kyoto] Me enjoying a traditional Japanese kaiseki meal in a ryokan somewhere outside Kyoto PhD student I am currently nearing the end of my PhD and planning to submit by the end of the year. |
| rentzsch | [Me] PhD student I started a 3-year PhD in the lab in November 2007, funded by a EU grant (ENFIN). The ENFIN Network of Excellence aims at close collaboration between experimental and computational groups throughout Europe. Current Research My work focuses on protein functional annotation using sequence, sequence profile, and clustering-based methods. This is to enrich functional annotation data for the CATH and Gene3D resources and will form the basis of domain-centric comparative (meta)g… |
| sillitoe | [Me with one of the Sillitoe clan (I'm the one on the right)] CATH Technical Manager I am responsible for the technical aspect of CATH. This generally involves maintaining and developing both the front-end interfaces (internal and external web pages and webservices) and back-end code library and databases. |
