CATH Domain 4ypoA02

CATH Classification

Level	CATH Code	Description
	6	Special
	6.10	Helix non-globular
	6.10.240	ProC C-terminal domain-like fold
	6.10.240.10

Domain Context

CATH Clusters

Superfamily	6.10.240.10
Functional Family

Enzyme Information

1.1.1.86

Ketol-acid reductoisomerase (NADP(+)).

based on mapping to UniProt P9WKJ7

(1) (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-hydroxy-2- methyl-3-oxobutanoate + NADPH. (2) (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2- ethyl-3-oxobutanoate + NADPH.

-!- The enzyme, found in many bacteria and archaea, is specific for NADPH (cf. EC 1.1.1.382 and EC 1.1.1.383). -!- Formerly EC 1.1.1.89.

UniProtKB Entries (1)

P9WKJ7

ILVC_MYCTU

Mycobacterium tuberculosis H37Rv

Ketol-acid reductoisomerase (NADP(+))

PDB Structure

PDB	4YPO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 angstrom resolution - a potential target for anti-tuberculosis drug discovery. Lv, Y., Kandale, A., Wun, S.J., McGeary, R.P., Williams, S.J., Kobe, B., Sieber, V., Schembri, M.A., Schenk, G., Guddat, L.W. Febs J.