CATH Domain 1u8xX02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.110	L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
	3.90.110.10	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Domain Context

CATH Clusters

Superfamily	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family

Enzyme Information

3.2.1.122

Maltose-6'-phosphate glucosidase.

based on mapping to UniProt P54716

Alpha-maltose 6'-phosphate + H(2)O = D-glucose + D-glucose 6-phosphate.

-!- Hydrolyzes a variety of 6-phospho-alpha-D-glucosides, including alpha-maltose 6-phosphate, alpha,alpha-trehalose 6-phosphate, sucrose 6-phosphate and p-nitrophenyl-alpha-D-glucopyranoside 6-phosphate (as a chromogenic substrate). -!- The enzyme is activated by Fe(2+), Mn(2+), Co(2+) and Ni(2+). -!- It is rapidly inactivated in air.

UniProtKB Entries (1)

P54716

GLVA_BACSU

Bacillus subtilis subsp. subtilis str. 168

Maltose-6'-phosphate glucosidase

PDB Structure

PDB	1U8X
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Novel Catalytic Mechanism of Glycoside Hydrolysis Based on the Structure of an NAD(+)/Mn(2+)-Dependent Phospho-alpha-Glucosidase from Bacillus subtilis. Rajan, S.S., Yang, X., Collart, F., Yip, V.L., Withers, S.G., Varrot, A., Thompson, J., Davies, G.J., Anderson, W.F. STRUCTURE