# STOCKHOLM 1.0
#=GF ID 3.90.15.10/FF/000005
#=GF DE DNA topoisomerase I
#=GF AC 3.90.15.10/FF/000005
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 50.686
#=GS E5RIC7/170-343      AC E5RIC7
#=GS E5RIC7/170-343      OS Homo sapiens
#=GS E5RIC7/170-343      DE DNA topoisomerase I
#=GS E5RIC7/170-343      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; 
#=GS E5RIC7/170-343      DR GO; GO:0005634; GO:0005739; 
#=GS B4E061/63-217       AC B4E061
#=GS B4E061/63-217       OS Homo sapiens
#=GS B4E061/63-217       DE DNA topoisomerase I
#=GS B4E061/63-217       DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo; Homo sapiens; 
#=GS A7SLG4/170-323      AC A7SLG4
#=GS A7SLG4/170-323      OS Nematostella vectensis
#=GS A7SLG4/170-323      DE DNA topoisomerase I
#=GS A7SLG4/170-323      DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; 
#=GS W4YBW8/509-663      AC W4YBW8
#=GS W4YBW8/509-663      OS Strongylocentrotus purpuratus
#=GS W4YBW8/509-663      DE DNA topoisomerase I
#=GS W4YBW8/509-663      DR ORG; Eukaryota; Metazoa; Echinodermata; Echinozoa; Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae; Strongylocentrotus; Strongylocentrotus purpuratus; 
#=GS H2Y8H6/238-392      AC H2Y8H6
#=GS H2Y8H6/238-392      OS Ciona savignyi
#=GS H2Y8H6/238-392      DE DNA topoisomerase I
#=GS H2Y8H6/238-392      DR ORG; Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona; Phlebobranchia; Cionidae; Ciona; Ciona savignyi; 
#=GS A0A2R8QCN1/150-304  AC A0A2R8QCN1
#=GS A0A2R8QCN1/150-304  OS Danio rerio
#=GS A0A2R8QCN1/150-304  DE DNA topoisomerase I
#=GS A0A2R8QCN1/150-304  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Otomorpha; Ostariophysi; Cypriniphysae; Cypriniformes; Cyprinoidei; Cyprinidae; Danio; Danio rerio; 
#=GS H9G579/186-340      AC H9G579
#=GS H9G579/186-340      OS Anolis carolinensis
#=GS H9G579/186-340      DE DNA topoisomerase I
#=GS H9G579/186-340      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Lepidosauria; Squamata; Iguania; Dactyloidae; Anolis; Anolis carolinensis; 
#=GS F1SEV4/186-340      AC F1SEV4
#=GS F1SEV4/186-340      OS Sus scrofa
#=GS F1SEV4/186-340      DE DNA topoisomerase I
#=GS F1SEV4/186-340      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Suina; Suidae; Sus; Sus scrofa; 
#=GS A0A2Y9T478/186-340  AC A0A2Y9T478
#=GS A0A2Y9T478/186-340  OS Physeter catodon
#=GS A0A2Y9T478/186-340  DE DNA topoisomerase I
#=GS A0A2Y9T478/186-340  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Cetacea; Odontoceti; Physeteridae; Physeter; Physeter catodon; 
#=GS A0A383YVP4/186-340  AC A0A383YVP4
#=GS A0A383YVP4/186-340  OS Balaenoptera acutorostrata scammoni
#=GS A0A383YVP4/186-340  DE DNA topoisomerase I
#=GS A0A383YVP4/186-340  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Cetacea; Mysticeti; Balaenopteridae; Balaenoptera; Balaenoptera acutorostrata; Balaenoptera acutorostrata scammoni; 
#=GS F6RCY1/170-324      AC F6RCY1
#=GS F6RCY1/170-324      OS Ciona intestinalis
#=GS F6RCY1/170-324      DE DNA topoisomerase I
#=GS F6RCY1/170-324      DR ORG; Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona; Phlebobranchia; Cionidae; Ciona; Ciona intestinalis; 
#=GS A0A1D5QJV3/170-324  AC A0A1D5QJV3
#=GS A0A1D5QJV3/170-324  OS Macaca mulatta
#=GS A0A1D5QJV3/170-324  DE DNA topoisomerase I
#=GS A0A1D5QJV3/170-324  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca mulatta; 
#=GS A0A2K5KDL2/170-324  AC A0A2K5KDL2
#=GS A0A2K5KDL2/170-324  OS Colobus angolensis palliatus
#=GS A0A2K5KDL2/170-324  DE DNA topoisomerase I
#=GS A0A2K5KDL2/170-324  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Colobinae; Colobus; Colobus angolensis; Colobus angolensis palliatus; 
#=GS K7EUC4/196-350      AC K7EUC4
#=GS K7EUC4/196-350      OS Pongo abelii
#=GS K7EUC4/196-350      DE DNA topoisomerase I
#=GS K7EUC4/196-350      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Ponginae; Pongo; Pongo abelii; 
#=GS A0A2R9AZF9/170-324  AC A0A2R9AZF9
#=GS A0A2R9AZF9/170-324  OS Pan paniscus
#=GS A0A2R9AZF9/170-324  DE DNA topoisomerase I
#=GS A0A2R9AZF9/170-324  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Pan; Pan paniscus; 
#=GS A0A2K5ZFU3/170-324  AC A0A2K5ZFU3
#=GS A0A2K5ZFU3/170-324  OS Mandrillus leucophaeus
#=GS A0A2K5ZFU3/170-324  DE DNA topoisomerase I
#=GS A0A2K5ZFU3/170-324  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Mandrillus; Mandrillus leucophaeus; 
#=GS A0A2K5M9F2/186-340  AC A0A2K5M9F2
#=GS A0A2K5M9F2/186-340  OS Cercocebus atys
#=GS A0A2K5M9F2/186-340  DE DNA topoisomerase I
#=GS A0A2K5M9F2/186-340  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Cercocebus; Cercocebus atys; 
#=GS A0A2K6QCC6/186-340  AC A0A2K6QCC6
#=GS A0A2K6QCC6/186-340  OS Rhinopithecus roxellana
#=GS A0A2K6QCC6/186-340  DE DNA topoisomerase I
#=GS A0A2K6QCC6/186-340  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Colobinae; Rhinopithecus; Rhinopithecus roxellana; 
#=GS A0A2I2Y7X3/170-324  AC A0A2I2Y7X3
#=GS A0A2I2Y7X3/170-324  OS Gorilla gorilla gorilla
#=GS A0A2I2Y7X3/170-324  DE DNA topoisomerase I
#=GS A0A2I2Y7X3/170-324  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Gorilla; Gorilla gorilla; Gorilla gorilla gorilla; 
#=GS A0A2J8LFR0/234-388  AC A0A2J8LFR0
#=GS A0A2J8LFR0/234-388  OS Pan troglodytes
#=GS A0A2J8LFR0/234-388  DE DNA topoisomerase I
#=GS A0A2J8LFR0/234-388  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Pan; Pan troglodytes; 
#=GS H2Y8H5/261-415      AC H2Y8H5
#=GS H2Y8H5/261-415      OS Ciona savignyi
#=GS H2Y8H5/261-415      DE DNA topoisomerase I
#=GS H2Y8H5/261-415      DR ORG; Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona; Phlebobranchia; Cionidae; Ciona; Ciona savignyi; 
#=GS F1QTQ7/338-527      AC F1QTQ7
#=GS F1QTQ7/338-527      OS Danio rerio
#=GS F1QTQ7/338-527      DE DNA topoisomerase I
#=GS F1QTQ7/338-527      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Otomorpha; Ostariophysi; Cypriniphysae; Cypriniformes; Cyprinoidei; Cyprinidae; Danio; Danio rerio; 
#=GS A0A1D5QET4/186-340  AC A0A1D5QET4
#=GS A0A1D5QET4/186-340  OS Macaca mulatta
#=GS A0A1D5QET4/186-340  DE DNA topoisomerase I
#=GS A0A1D5QET4/186-340  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca mulatta; 
#=GS F6U741/250-404      AC F6U741
#=GS F6U741/250-404      OS Macaca mulatta
#=GS F6U741/250-404      DE DNA topoisomerase I
#=GS F6U741/250-404      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae; Macaca; Macaca mulatta; 
#=GS A0A2R9B3H0/170-324  AC A0A2R9B3H0
#=GS A0A2R9B3H0/170-324  OS Pan paniscus
#=GS A0A2R9B3H0/170-324  DE DNA topoisomerase I
#=GS A0A2R9B3H0/170-324  DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Pan; Pan paniscus; 
#=GS I3LTP0/172-326      AC I3LTP0
#=GS I3LTP0/172-326      OS Sus scrofa
#=GS I3LTP0/172-326      DE DNA topoisomerase I
#=GS I3LTP0/172-326      DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Laurasiatheria; Suina; Suidae; Sus; Sus scrofa; 
#=GF SQ 26
E5RIC7/170-343              -CSKLKGETAWQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLTVSWDGPAKPRNYRDHFPPQTTSLNKHLQELMDGLTA----------------------------------
B4E061/63-217               -CSKLKGETAWQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLT-------------------TTSLNKHLQELMDGLTA----------------------------------
A7SLG4/170-323              -TSRLKGEKDWRKYETARKLKECVDKIREDYRKDWKSKEMRLRQRGVALYFIDKLALRAGHEKDD-DTADTVGCCSLRVEHIKLHEEWEDKECVVEFDFLGKDSVRYRNFVPIEKRAFKNMKLFMEGKQEGDDLFDRLT-------------------TTSVNKYLSELMEGLSA----------------------------------
W4YBW8/509-663              -SSRIKGEKDWAKYETARKLKESVDRIRNEYREDWKSKEMRVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHIQLYEEQDGMEFVVKFDFLGKDSIRYENSVPVEKRVFKNLKLFTENKKGEDNLFDRLN-------------------TSILNKYLQELMEGLTA----------------------------------
H2Y8H6/238-392              -SSRVKGEKDWQKYEIARNLKTKVDRIREDYMRDLKSSEMMIRQRAVALYFIDKLALRAGNEKEDGESADTVGCCSLRCEHIKLHKQLDGKDFIVEFDFLGKDSIRYYNKVPVLKQVFKNLVLFTENKEGGDDLFDRLN-------------------TSTLNKYLNSLMEGLTA----------------------------------
A0A2R8QCN1/150-304          -NSKLKGEKDWEKYEVARKLKTCVDAIRTQYQEDLKSKQMGTRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHITLHDALDDQKCVVEFDFLGKDCIRYYNKVPVTKRVFKNLKLFMENKQGGDDLFDRLN-------------------TASLNKHLSSLMPGLTA----------------------------------
H9G579/186-340              -SSKLKGEKDWQKYEVARHLKGVVKKIRTRYRADWKSKDMKKRQISVALYFIDRLALRAGNEKEKGETADTVGCCSLRVEHITLHPRLGGKGNVVEFDFLGKDCIRYYNQVPVEKQVFKNLQLFMENKDPRDCLFDRLS-------------------TTSLNKHLQDLMDGLTA----------------------------------
F1SEV4/186-340              -SSKLKGERDWEKYEVARRLKGVVDEIRSRYRADWKSREMKARQRAVALYFIDKLALRAGNEKEEGESADTVGCCSLRVEHVQLHPEADGCPYVVEFDFLGKDSIRYYNKVPVEKPVYRNLQLFLENKDPGEELFDRLT-------------------TASLNKHLQDLMDGLTA----------------------------------
A0A2Y9T478/186-340          -SSKLKGERDWEKYEAARRLKGVVDRIRSQYRADWRSREMKARQRAVALYVIDKLALRAGHEKEEGEAADTVGCCSLRVEHVQLHPEADGCPYVVEFDFLGKDSIRYYNQVPVEKPVYENLQLFMENKGPGDELFDRLT-------------------TASLNKHLQDLMDGLTA----------------------------------
A0A383YVP4/186-340          -SSKLKGERDWEKYEVARRLKGVVGEIRSQYQADWKSPEMKARQRAVALYFIDKLALRAGHEKEEGETADTVGCCSLRVEHIRLHPEADGRPYVVEFDFLGKDSIRYYNRVPVEKPVYENLQLFMENKGPGAELFDRLT-------------------TARLNKHLQDLMDGLTA----------------------------------
F6RCY1/170-324              -SSRVKGEKDWQKYEVARNLKSKVDRIREDYMRDLKSDEMMVRQRAVALYFIDKLALRAGNEKEDGESADTVGCCSLRCEHIKLHKHLDGKDFIVEFDFLGKDSIRYYNKVPVLKQVFKNLVLFTENKEGPDDLFDRLN-------------------TSTLNKYLNSLMDGLTA----------------------------------
A0A1D5QJV3/170-324          -CSKLKGEKAWQKFETARRLRGFVDEIRSQYQADWKSQEMKTRQRAVALYFIDKLALRAGNEKDDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDSIRYYNRVPVEKPVYKNLQLFMKNKDPQDDLFDRLT-------------------TTSLNKHLHELMDGLTA----------------------------------
A0A2K5KDL2/170-324          -CSKLKGEKAWQKFETARRLRGFVDEIRSQYRADWKSQEMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDSIRYYNRVPVEKPVYKNLQLFMKNKDPWDDLFDRLT-------------------TTSLNKHLQELMDGLTA----------------------------------
K7EUC4/196-350              -CSKLKGEKAWQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEVADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLT-------------------TTSLNKHLQELMDGLTA----------------------------------
A0A2R9AZF9/170-324          -CSKLKGETAWQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMESKGPRDNLFDRLT-------------------TTSLNKHLQELMDGLTA----------------------------------
A0A2K5ZFU3/170-324          -CSKLKGEKAWQKFETARRLRGFVDEIRSQYRADWKSQEMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDSIRYYNRVPVEKPVYKNLQLFMKNKDPQDDLFDRLT-------------------TTSLNKHLHELMDGLTA----------------------------------
A0A2K5M9F2/186-340          -CSKLKGEKAWQKFETARRLRGFVDEIRSQYRADWKSQEMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFPGKDSIRYYNRVPVEKPVYKNLQLFMKNKDPQDDLFDRLT-------------------TTSLNKHLHELMDGLTA----------------------------------
A0A2K6QCC6/186-340          -CSKLKGEKAWQKFETARRLQGFVDEIRSQYRADWKSQEMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDSIRYYNRVPVEKPVYKNLQLFMKNKAPRDDLFDRLT-------------------TTSLNKHLQELMDGLTA----------------------------------
A0A2I2Y7X3/170-324          -CSKLKGETAWQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLT-------------------TISLNKHLQELMDGLTA----------------------------------
A0A2J8LFR0/234-388          -CSKLKGETAWQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMESKGPRDNLFDRLT-------------------TTSLNKHLQELMDGLTA----------------------------------
H2Y8H5/261-415              -SSRVKGEKDWQKYEIARNLKTKVDRIREDYMRDLKSSEMMIRQRAVALYFIDKLALRAGNEKEDGESADTVGCCSLRCEHIKLHKQLDGKDFIVEFDFLGKDSIRYYNKVPVLKQVFKNLVLFTENKEGGDDLFDRLN-------------------TSTLNKYLNSLMEGLTA----------------------------------
F1QTQ7/338-527              PSSRIKGEKDWQKYETARRLKKCVERIRAQYREDWRSKEMRIRQRAVALYFIDKLALRAGNEKDEGETADTVGCCSLRVEHIKLHPQLDGQDYVVEFDFLGKDSIRYYNKIPVEKRVFKNLQLFLENKQSEDDLFDRLN-------------------TSILNKYLQELMDGLTAKVFRTYNASITLQQQLNELTSRETSLRRSSPITE
A0A1D5QET4/186-340          -CSKLKGEKAWQKFETARRLRGFVDEIRSQYQADWKSQEMKTRQRAVALYFIDKLALRAGNEKDDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDSIRYYNRVPVEKPVYKNLQLFMKNKDPQDDLFDRLT-------------------TTSLNKHLHELMDGLTA----------------------------------
F6U741/250-404              -CSKLKGEKAWQKFETARRLRGFVDEIRSQYQADWKSQEMKTRQRAVALYFIDKLALRAGNEKDDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDSIRYYNRVPVEKPVYKNLQLFMKNKDPQDDLFDRLT-------------------TTSLNKHLHELMDGLTA----------------------------------
A0A2R9B3H0/170-324          -CSKLKGETAWQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMESKGPRDNLFDRLT-------------------TTSLNKHLQELMDGLTA----------------------------------
I3LTP0/172-326              -SSKLKGERDWEKYEVARRLKGVVDEIRSRYRADWKSREMKARQRAVALYFIDKLALRAGNEKEEGESADTVGCCSLRVEHVQLHPEADGCPYVVEFDFLGKDSIRYYNKVPVEKPVYRNLQLFLENKDPGEELFDRLT-------------------TASLNKHLQDLMDGLTA----------------------------------
#=GC scorecons              05976999659697959969753975995595596894895499879999899899999979976785999999999969975985648744579899989996899795898695877985996779454869999960000000000000000000955899795599799890000000000000000000000000000000000
#=GC scorecons_70           __******__*****_**_**__**_**__*__****_**__*************************_**************_**___**___****************_***_*_*****_**_***___*******____________________*__*****__*******__________________________________
#=GC scorecons_80           __**_***__*_***_**_*___**_**__*__*_**_**__**********************_**_**********_**__**___**___**********_*****_***_*_*****_**_***___*_*****____________________*__*****__**_****__________________________________
#=GC scorecons_90           __*__***__*_*_*_**_*___*__**__*__*_**_**__***_**************_**___*_**********_**__**___*_____*********_***_*_***_*_*__**_**___*_____*****____________________*__***_*__**_****__________________________________
//