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CATH Superfamily 3.90.1150.10

Aspartate Aminotransferase, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aspartate Aminotransferase, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Aspartate aminotransferase

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aspartate transaminase. [EC: 2.6.1.1]
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
  • Also acts on L-tyrosine, L-phenylalanine and L-tryptophan.
  • This activity can be formed from EC 2.6.1.57 by controlled proteolysis.
 15315 A0A023YUU3 A0A023YUU3 A0A023YUU3 A0A023YUU3 A0A023YUU3 A0A023YUU3 A0A023YUU3 A0A023YUU3 A0A023YUU3 A0A023YUU3
(15305 more...)
Aromatic-amino-acid transaminase. [EC: 2.6.1.57]
An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.
  • L-methionine can also act as donor, more slowly.
  • Oxaloacetate can act as acceptor.
  • Controlled proteolysis converts the enzyme to EC 2.6.1.1.
 267 A0A024L7A0 A0A024L7A0 A0A024L7A0 A0A024L7A0 A0A024L7A0 A0A024L7A0 A0A024L7A0 A0A024L7A0 A0A024L7A0 A0A024L7A0
(257 more...)
Beta-methylphenylalanine transaminase. [EC: 2.6.1.107]
(2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3- phenylbutanoate + L-glutamate.
  • Isolated from the bacterium Streptomyces hygroscopicus NRRL3085.
  • It is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin.
 156 A0A024L7A0 A0A024L7A0 A0A024L7A0 A0A024L7A0 A0A024L7A0 A0A024L7A0 A0A024L7A0 A0A024L7A0 A0A024L7A0 A0A024L7A0
(146 more...)
Tyrosine transaminase. [EC: 2.6.1.5]
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.
  • L-phenylalanine can act instead of L-tyrosine.
  • The mitochondrial enzyme may be identical with EC 2.6.1.1.
  • The three isoenzymic forms are interconverted by EC 3.4.22.32 and EC 3.4.22.33.
  • The enzyme can also catalyze the final step in the methionine-salvage pathway of Klebsiella pneumoniae.
 1 O85746
Kynurenine--oxoglutarate transaminase. [EC: 2.6.1.7]
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
  • Also acts on 3-hydroxykynurenine.
  • The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
 1 Q55F21
Cysteine transaminase. [EC: 2.6.1.3]
L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate.
    		 1 P05201