# STOCKHOLM 1.0
#=GF ID 3.40.430.10/FF/000017
#=GF DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GF AC 3.40.430.10/FF/000017
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 44.200
#=GS 3rg9B00/23-240     AC Q27783
#=GS 3rg9B00/23-240     OS Trypanosoma brucei brucei
#=GS 3rg9B00/23-240     DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS 3rg9B00/23-240     DR CATH; 3rg9; B:23-240; 
#=GS 3rg9B00/23-240     DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; 
#=GS 3rg9B00/23-240     DR EC; 1.5.1.3; 2.1.1.45; 
#=GS P07382/5-227       AC P07382
#=GS P07382/5-227       OS Leishmania major
#=GS P07382/5-227       DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS P07382/5-227       DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania major species complex; Leishmania major; 
#=GS P07382/5-227       DR GO; GO:0005737; 
#=GS P07382/5-227       DR EC; 1.5.1.3; 2.1.1.45; 
#=GS Q582G3/23-239      AC Q582G3
#=GS Q582G3/23-239      OS Trypanosoma brucei brucei TREU927
#=GS Q582G3/23-239      DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS Q582G3/23-239      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; 
#=GS Q582G3/23-239      DR GO; GO:0004146; GO:0005737; GO:0005739; GO:0006545; GO:0009165; GO:0010608; GO:0046105; 
#=GS 3rg9A00/23-240     AC Q27783
#=GS 3rg9A00/23-240     OS Trypanosoma brucei brucei
#=GS 3rg9A00/23-240     DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS 3rg9A00/23-240     DR CATH; 3rg9; A:23-240; 
#=GS 3rg9A00/23-240     DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; 
#=GS 3rg9A00/23-240     DR EC; 1.5.1.3; 2.1.1.45; 
#=GS A0A1G4IK32/23-239  AC A0A1G4IK32
#=GS A0A1G4IK32/23-239  OS Trypanosoma equiperdum
#=GS A0A1G4IK32/23-239  DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS A0A1G4IK32/23-239  DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma equiperdum; 
#=GS P16126/5-228       AC P16126
#=GS P16126/5-228       OS Leishmania amazonensis
#=GS P16126/5-228       DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS P16126/5-228       DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania mexicana species complex; Leishmania amazonensis; 
#=GS P16126/5-228       DR EC; 1.5.1.3; 2.1.1.45; 
#=GS A0A3S5H5T0/5-227   AC A0A3S5H5T0
#=GS A0A3S5H5T0/5-227   OS Leishmania donovani
#=GS A0A3S5H5T0/5-227   DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS A0A3S5H5T0/5-227   DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania donovani; 
#=GS Q8MQV3/5-227       AC Q8MQV3
#=GS Q8MQV3/5-227       OS Leishmania infantum
#=GS Q8MQV3/5-227       DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS Q8MQV3/5-227       DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania infantum; 
#=GS E9AKW4/5-231       AC E9AKW4
#=GS E9AKW4/5-231       OS Leishmania mexicana MHOM/GT/2001/U1103
#=GS E9AKW4/5-231       DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS E9AKW4/5-231       DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania mexicana species complex; Leishmania mexicana; 
#=GS Q27783/23-239      AC Q27783
#=GS Q27783/23-239      OS Trypanosoma brucei brucei
#=GS Q27783/23-239      DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS Q27783/23-239      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; 
#=GS Q27783/23-239      DR EC; 1.5.1.3; 2.1.1.45; 
#=GS E9B8U9/5-227       AC E9B8U9
#=GS E9B8U9/5-227       OS Leishmania donovani BPK282A1
#=GS E9B8U9/5-227       DE Bifunctional dihydrofolate reductase-thymidylate synthase
#=GS E9B8U9/5-227       DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania donovani; 
#=GF SQ 11
3rg9B00/23-240             R----------------PPLRPFSVVVASDEKGGIGDGGTIPWEIPEDMQYFRRVTTNLRGKNVKPSPSKRNAVVMGRKTWDSLPPKFRPLSNRLNVVLSRSATKEQLLAGIPDPIKRAEAANDVVAVNGGLEDALRMLVSKEHTSSIETVFCIGGGTIYKQALCAPCVNVLQAIHRTVVRPASNSCSVFFDIPAAGTKTPEGLELVRESITDERVSTGAGGKKYQFEKLVPRN
P07382/5-227               AARFKIPMPETKADFAFPSLRAFSIVVALDMQHGIGDGESIPWRVPEDMTFFKNQTTLLRNKK-PPTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEG-QRAAAAQDVVVVNGGLAEALRLLARPLYCSSIETAYCVGGAQVYADAMLSPCIEKLQEVYLTRIYATAPACTRFFPFPPENAATAWDL-----ASSQGRRKSEAEGLEFEICKY----
Q582G3/23-239              R----------------PPLRPFSVVVASDEKGGIGDGGTIPWEIPEDMQYFRRVTTNLRGKNVKPSPSKRNAVVMGRKTWDSLPPKFRPLSNRLNVVLSRSATKEQLLAGIPDPIKRAEAANDVVAVNGGLEDALRMLVSKEHTSSIETVFCIGGGTIYKQALCAPCVNVLQAIHRTVVRPASNSCSVFFDIPAAGTKTLEGLELVRESITDERVSTGAGGKKYQFEKLVPR-
3rg9A00/23-240             R----------------PPLRPFSVVVASDEKGGIGDGGTIPWEIPEDMQYFRRVTTNLRGKNVKPSPSKRNAVVMGRKTWDSLPPKFRPLSNRLNVVLSRSATKEQLLAGIPDPIKRAEAANDVVAVNGGLEDALRMLVSKEHTSSIETVFCIGGGTIYKQALCAPCVNVLQAIHRTVVRPASNSCSVFFDIPAAGTKTPEGLELVRESITDERVSTGAGGKKYQFEKLVPRN
A0A1G4IK32/23-239          R----------------PPLRPFSVVVASDEKGGIGDGGTIPWEIPEDMQYFRRVTTNLRGKNVKPSPSKRNAVVMGRKTWDSLPPKFRPLSNRLNVVLSRSATKEQLLAGIPDPIKRAEAANDVVAVNGGLEDALRMLVSKEHTSSIETVFCIGGGTIYKQALCAPCVNVLQAIHRTVVRPASNSCSVFFDIPAAGTKTLEGLELVRESITDERVSTGAGGKKYQFEKLVPR-
P16126/5-228               AAKFKIPMPVTKADFAFPSLRAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKK-PPTDKKRNAVVMGRKTWESVPVKFRPLKGRLNVVLSSKATVEELLAPLPEE-KRAAAAQDIVVVNGGLAAAVRLLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIHTTAPACTRFFPFPPENAATAWDL-----ASSQGRRKSAVDGLEFEICKYV---
A0A3S5H5T0/5-227           AARFKIPMPATKADFAFPSLRAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKK-PPTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEG-KRAAAAQDVVVVNGGLAEALRLLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFPFPPENTTTAWDL-----ASSQGRRKSEADGLEFEICKY----
Q8MQV3/5-227               AARFKIPMPATKADFAFPSLRAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKK-PPTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEG-KRAAAAQDVVVVNGGLAEALRLLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFPFPPENTTTAWDL-----ASSQGRRKSEADGLEFEICKY----
E9AKW4/5-231               AAKFKIPMPVTKADFAFPSLRAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKK-PPTDKKRNAVVMGRKTWESVPVKFRPLKGRLNVVLSSKATVEELLAPLPEE-KRAAAAQDIVVVNGGLAAALRLLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIHTTAPACTRFFPFPPENAATAWDL-----ASSQGRRKSAVDGLEFEICKYVPRN
Q27783/23-239              R----------------PPLRPFSVVVASDEKGGIGDGGTIPWEIPEDMQYFRRVTTNLRGKNVKPSPSKRNAVVMGRKTWDSLPPKFRPLSNRLNVVLSRSATKEQLLAGIPDPIKRAEAANDVVAVNGGLEDALRMLVSKEHTSSIETVFCIGGGTIYKQALCAPCVNVLQAIHRTVVRPASNSCSVFFDIPAAGTKTPEGLELVRESITDERVSTGAGGKKYQFEKLVPR-
E9B8U9/5-227               AARFKIPMPATKADFAFPSLRAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQTTLLRNKK-PPTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEG-KRAAAAQDVVVVNDGLAEALRLLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLTRIYTTAPACTRFFPFPPENTTTAWDL-----ASSQGRRKSEADGLEFEICKY----
#=GC scorecons             521222222122222229699699799959565999996699957999947975499499596159645999999999999796959999955999799955994969995697418995995979699899559896965547599999679799657955964699864995774947556656964995596556495469111116565694565759467654953220
#=GC scorecons_70          _________________*_**_******_*_*_*****__***_*****_***__**_**_*___*___****************_*****__*******__**_*****_***__***_**_***_*****__*****____*_*****_*****__**__**__***__**_**_*_*__*___*__**__*___*_*___*__________*____*_*__**__*_____
#=GC scorecons_80          _________________*_**_**_***_*___*****__***__****_**___**_**_*___*___************_*_*_*****__*******__**_*_***__*___***_**_***_*****__***_*______*****_**_**___*__*___***__**____*________*__**__*_____*___*__________*____*_*__*___*_____
#=GC scorecons_90          _________________*_**_**_***_*___*****__***__****__*___**_**_*___*___************_*_*_*****__***_***__**_*_***__*___***_**_*_*_**_**__***_*______*****__*_**___*__*___***__**____*________*__**__*_____*___*__________*______*______*_____
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