The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Periplasmic binding protein-like II
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 105: Serotransferrin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 24 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 P02787 (/IPI) P02788 (/IPI) P02788 (/IPI) P24627 (/IPI) P24627 (/IPI) P24627 (/IPI) Q921I1 (/IPI)
Cysteine-type endopeptidase inhibitor activity GO:0004869
Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
5 P02788 (/IDA) P02788 (/IDA) P24627 (/IDA) P24627 (/IDA) P24627 (/IDA)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
3 P24627 (/IMP) P24627 (/IMP) P24627 (/IMP)
Lipopolysaccharide binding GO:0001530
Interacting selectively and non-covalently with lipopolysaccharide.
2 P02788 (/IMP) P02788 (/IMP)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2 P02788 (/TAS) P02788 (/TAS)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
2 P02788 (/IDA) P02788 (/IDA)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
2 P02788 (/IDA) P02788 (/IDA)
Protein serine/threonine kinase activator activity GO:0043539
Binds to and increases the activity of a protein serine/threonine kinase.
2 P02788 (/IDA) P02788 (/IDA)
Lipopolysaccharide binding GO:0001530
Interacting selectively and non-covalently with lipopolysaccharide.
1 P08071 (/ISO)
Enzyme inhibitor activity GO:0004857
Binds to and stops, prevents or reduces the activity of an enzyme.
1 Q9DBD0 (/IDA)
Cysteine-type endopeptidase inhibitor activity GO:0004869
Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
1 P08071 (/ISO)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
1 P08071 (/ISO)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
1 P02787 (/IDA)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
1 Q921I1 (/ISO)
Ferric iron binding GO:0008199
Interacting selectively and non-covalently with ferric iron, Fe(III).
1 P12346 (/IDA)
Ferric iron binding GO:0008199
Interacting selectively and non-covalently with ferric iron, Fe(III).
1 Q921I1 (/ISO)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
1 P08071 (/ISO)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
1 P08071 (/IDA)
Iron chaperone activity GO:0034986
Directly binding to and delivering iron ions to a target protein.
1 P02787 (/IDA)
Iron chaperone activity GO:0034986
Directly binding to and delivering iron ions to a target protein.
1 Q921I1 (/ISO)
Protein serine/threonine kinase activator activity GO:0043539
Binds to and increases the activity of a protein serine/threonine kinase.
1 P08071 (/ISO)
Transferrin receptor binding GO:1990459
Interacting selectively and non-covalently with the transferrin receptor.
1 P02787 (/IPI)
Transferrin receptor binding GO:1990459
Interacting selectively and non-covalently with the transferrin receptor.
1 Q921I1 (/ISO)
Transferrin receptor binding GO:1990459
Interacting selectively and non-covalently with the transferrin receptor.
1 P02787 (/TAS)

There are 113 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of cytokine production GO:0001817
Any process that modulates the frequency, rate, or extent of production of a cytokine.
9 O77698 (/ISS) O77811 (/ISS) P08071 (/ISS) P14632 (/ISS) P24627 (/ISS) P24627 (/ISS) P24627 (/ISS) Q29477 (/ISS) Q9TUM0 (/ISS)
Innate immune response in mucosa GO:0002227
Any process of the innate immune response that takes place in the mucosal tissues.
9 O77698 (/ISS) O77811 (/ISS) P08071 (/ISS) P14632 (/ISS) P24627 (/ISS) P24627 (/ISS) P24627 (/ISS) Q29477 (/ISS) Q9TUM0 (/ISS)
Antifungal humoral response GO:0019732
An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster.
9 O77698 (/ISS) O77811 (/ISS) P08071 (/ISS) P14632 (/ISS) P24627 (/ISS) P24627 (/ISS) P24627 (/ISS) Q29477 (/ISS) Q9TUM0 (/ISS)
Negative regulation of lipopolysaccharide-mediated signaling pathway GO:0031665
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.
9 O77698 (/ISS) O77811 (/ISS) P08071 (/ISS) P14632 (/ISS) P24627 (/ISS) P24627 (/ISS) P24627 (/ISS) Q29477 (/ISS) Q9TUM0 (/ISS)
Regulation of tumor necrosis factor production GO:0032680
Any process that modulates the frequency, rate, or extent of tumor necrosis factor production.
9 O77698 (/ISS) O77811 (/ISS) P08071 (/ISS) P14632 (/ISS) P24627 (/ISS) P24627 (/ISS) P24627 (/ISS) Q29477 (/ISS) Q9TUM0 (/ISS)
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
9 O77698 (/ISS) O77811 (/ISS) P08071 (/ISS) P14632 (/ISS) P24627 (/ISS) P24627 (/ISS) P24627 (/ISS) Q29477 (/ISS) Q9TUM0 (/ISS)
Bone morphogenesis GO:0060349
The process in which bones are generated and organized.
9 O77698 (/ISS) O77811 (/ISS) P08071 (/ISS) P14632 (/ISS) P24627 (/ISS) P24627 (/ISS) P24627 (/ISS) Q29477 (/ISS) Q9TUM0 (/ISS)
Negative regulation of single-species biofilm formation in or on host organism GO:1900229
Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation in or on host organism.
9 O77698 (/ISS) O77811 (/ISS) P08071 (/ISS) P14632 (/ISS) P24627 (/ISS) P24627 (/ISS) P24627 (/ISS) Q29477 (/ISS) Q9TUM0 (/ISS)
Positive regulation of chondrocyte proliferation GO:1902732
Any process that increases the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.
9 O77698 (/ISS) O77811 (/ISS) P08071 (/ISS) P14632 (/ISS) P24627 (/ISS) P24627 (/ISS) P24627 (/ISS) Q29477 (/ISS) Q9TUM0 (/ISS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
8 O77698 (/ISS) O77811 (/ISS) P02788 (/ISS) P02788 (/ISS) P08071 (/ISS) P14632 (/ISS) Q29477 (/ISS) Q9TUM0 (/ISS)
Positive regulation of bone mineralization involved in bone maturation GO:1900159
Any process that activates or increases the frequency, rate or extent of bone mineralization involved in bone maturation.
8 O77698 (/ISS) O77811 (/ISS) P02788 (/ISS) P02788 (/ISS) P08071 (/ISS) P14632 (/ISS) Q29477 (/ISS) Q9TUM0 (/ISS)
Negative regulation of tumor necrosis factor (ligand) superfamily member 11 production GO:2000308
Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production.
8 O77698 (/ISS) O77811 (/ISS) P02788 (/ISS) P02788 (/ISS) P08071 (/ISS) P14632 (/ISS) Q29477 (/ISS) Q9TUM0 (/ISS)
Negative regulation of osteoclast development GO:2001205
Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development.
8 O77698 (/ISS) O77811 (/ISS) P02788 (/ISS) P02788 (/ISS) P08071 (/ISS) P14632 (/ISS) Q29477 (/ISS) Q9TUM0 (/ISS)
Antibacterial humoral response GO:0019731
An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.
6 O77698 (/ISS) O77811 (/ISS) P08071 (/ISS) P14632 (/ISS) Q29477 (/ISS) Q9TUM0 (/ISS)
Positive regulation of osteoblast proliferation GO:0033690
Any process that activates or increases the rate or extent of osteoblast proliferation.
6 O77698 (/ISS) O77811 (/ISS) P08071 (/ISS) P14632 (/ISS) Q29477 (/ISS) Q9TUM0 (/ISS)
Antibacterial humoral response GO:0019731
An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.
5 P02788 (/IDA) P02788 (/IDA) P24627 (/IDA) P24627 (/IDA) P24627 (/IDA)
Positive regulation of osteoblast proliferation GO:0033690
Any process that activates or increases the rate or extent of osteoblast proliferation.
5 P02788 (/IDA) P02788 (/IDA) P24627 (/IDA) P24627 (/IDA) P24627 (/IDA)
Negative regulation of cysteine-type endopeptidase activity GO:2000117
Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity.
5 P02788 (/IDA) P02788 (/IDA) P24627 (/IDA) P24627 (/IDA) P24627 (/IDA)
Retina homeostasis GO:0001895
A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function.
3 P02787 (/HEP) P02788 (/HEP) P02788 (/HEP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
3 P24627 (/IDA) P24627 (/IDA) P24627 (/IDA)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
3 P02787 (/TAS) P02788 (/TAS) P02788 (/TAS)
Positive regulation of bone mineralization involved in bone maturation GO:1900159
Any process that activates or increases the frequency, rate or extent of bone mineralization involved in bone maturation.
3 P24627 (/IDA) P24627 (/IDA) P24627 (/IDA)
Negative regulation of tumor necrosis factor (ligand) superfamily member 11 production GO:2000308
Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production.
3 P24627 (/IDA) P24627 (/IDA) P24627 (/IDA)
Negative regulation of osteoclast development GO:2001205
Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development.
3 P24627 (/IDA) P24627 (/IDA) P24627 (/IDA)
Regulation of cytokine production GO:0001817
Any process that modulates the frequency, rate, or extent of production of a cytokine.
2 P02788 (/IDA) P02788 (/IDA)
Innate immune response in mucosa GO:0002227
Any process of the innate immune response that takes place in the mucosal tissues.
2 P02788 (/IDA) P02788 (/IDA)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
2 P02787 (/TAS) P12346 (/TAS)
Humoral immune response GO:0006959
An immune response mediated through a body fluid.
2 P02788 (/TAS) P02788 (/TAS)
Antimicrobial humoral response GO:0019730
An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.
2 P02788 (/TAS) P02788 (/TAS)
Antifungal humoral response GO:0019732
An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster.
2 P02788 (/IDA) P02788 (/IDA)
Killing of cells of other organism GO:0031640
Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
2 P02788 (/IDA) P02788 (/IDA)
Killing of cells of other organism GO:0031640
Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
2 P02788 (/IMP) P02788 (/IMP)
Negative regulation of lipopolysaccharide-mediated signaling pathway GO:0031665
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.
2 P02788 (/IDA) P02788 (/IDA)
Regulation of tumor necrosis factor production GO:0032680
Any process that modulates the frequency, rate, or extent of tumor necrosis factor production.
2 P02788 (/IDA) P02788 (/IDA)
Negative regulation of ATPase activity GO:0032780
Any process that stops or reduces the rate of ATP hydrolysis by an ATPase.
2 P02788 (/IMP) P02788 (/IMP)
Siderophore-dependent iron import into cell GO:0033214
A process in which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors.
2 P02788 (/TAS) P02788 (/TAS)
Positive regulation of toll-like receptor 4 signaling pathway GO:0034145
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway.
2 P02788 (/IMP) P02788 (/IMP)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
2 P02788 (/IDA) P02788 (/IDA)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
2 P02788 (/TAS) P02788 (/TAS)
Negative regulation by host of viral process GO:0044793
A process in which a host organism stops, prevents or reduces the frequency, rate or extent of a process being mediated by a virus with which it is infected.
2 P02788 (/IMP) P02788 (/IMP)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
2 P02788 (/IMP) P02788 (/IMP)
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
2 P02788 (/IDA) P02788 (/IDA)
Negative regulation of viral process GO:0048525
Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant.
2 P02788 (/IMP) P02788 (/IMP)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
2 P02788 (/IMP) P02788 (/IMP)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
2 P02788 (/IDA) P02788 (/IDA)
Membrane disruption in other organism GO:0051673
The disruption of the membranes of another organism, leading to damage to its cells and possibly death of that organism.
2 P02788 (/IMP) P02788 (/IMP)
Bone morphogenesis GO:0060349
The process in which bones are generated and organized.
2 P02788 (/IDA) P02788 (/IDA)
Antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844
An immune response against microbes mediated by anti-microbial peptides in body fluid.
2 P02788 (/IMP) P02788 (/IMP)
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
2 P02788 (/IDA) P02788 (/IDA)
Negative regulation of single-species biofilm formation in or on host organism GO:1900229
Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation in or on host organism.
2 P02788 (/IDA) P02788 (/IDA)
Positive regulation of chondrocyte proliferation GO:1902732
Any process that increases the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.
2 P02788 (/IDA) P02788 (/IDA)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P12346 (/IEP)
Regulation of cytokine production GO:0001817
Any process that modulates the frequency, rate, or extent of production of a cytokine.
1 P08071 (/ISO)
Innate immune response in mucosa GO:0002227
Any process of the innate immune response that takes place in the mucosal tissues.
1 P08071 (/ISO)
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
1 P02787 (/TAS)
Iron ion transport GO:0006826
The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P12346 (/IDA)
Iron ion transport GO:0006826
The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q921I1 (/IMP)
Iron ion transport GO:0006826
The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q921I1 (/ISO)
Iron ion transport GO:0006826
The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P12346 (/TAS)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 P12346 (/ISS)
Acute-phase response GO:0006953
An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.
1 P12346 (/IEP)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
1 Q921I1 (/IDA)
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
1 Q921I1 (/IDA)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
1 Q921I1 (/IEP)
Response to lead ion GO:0010288
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
1 P12346 (/IEP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P12346 (/IEP)
Antibacterial humoral response GO:0019731
An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.
1 P08071 (/ISO)
Antifungal humoral response GO:0019732
An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster.
1 P08071 (/ISO)
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
1 Q921I1 (/IDA)
Killing of cells of other organism GO:0031640
Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
1 P08071 (/ISO)
Positive regulation of myelination GO:0031643
Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
1 P12346 (/IDA)
Positive regulation of myelination GO:0031643
Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
1 Q921I1 (/ISO)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
1 P02787 (/TAS)
Negative regulation of lipopolysaccharide-mediated signaling pathway GO:0031665
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.
1 P08071 (/ISO)
Regulation of tumor necrosis factor production GO:0032680
Any process that modulates the frequency, rate, or extent of tumor necrosis factor production.
1 P08071 (/ISO)
Negative regulation of ATPase activity GO:0032780
Any process that stops or reduces the rate of ATP hydrolysis by an ATPase.
1 P08071 (/ISO)
Transferrin transport GO:0033572
The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P02787 (/TAS)
Positive regulation of osteoblast proliferation GO:0033690
Any process that activates or increases the rate or extent of osteoblast proliferation.
1 P08071 (/ISO)
Positive regulation of toll-like receptor 4 signaling pathway GO:0034145
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway.
1 P08071 (/ISO)
Regulation of iron ion transport GO:0034756
Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P02787 (/IGI)
Regulation of iron ion transport GO:0034756
Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q921I1 (/ISO)
Positive regulation of phosphorylation GO:0042327
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.
1 Q921I1 (/IDA)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
1 P08071 (/ISO)
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
1 P02787 (/TAS)
Negative regulation by host of viral process GO:0044793
A process in which a host organism stops, prevents or reduces the frequency, rate or extent of a process being mediated by a virus with which it is infected.
1 P08071 (/ISO)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
1 P08071 (/ISO)
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
1 P08071 (/ISO)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
1 Q921I1 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q921I1 (/IDA)
Positive regulation of receptor-mediated endocytosis GO:0048260
Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
1 P02787 (/IDA)
Positive regulation of receptor-mediated endocytosis GO:0048260
Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
1 P02787 (/IGI)
Positive regulation of receptor-mediated endocytosis GO:0048260
Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
1 Q921I1 (/ISO)
Negative regulation of viral process GO:0048525
Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant.
1 P08071 (/ISO)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
1 P08071 (/ISO)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 P08071 (/ISO)
Membrane disruption in other organism GO:0051673
The disruption of the membranes of another organism, leading to damage to its cells and possibly death of that organism.
1 P08071 (/ISO)
Iron ion homeostasis GO:0055072
Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
1 P02787 (/IC)
Bone morphogenesis GO:0060349
The process in which bones are generated and organized.
1 P08071 (/ISO)
SMAD protein signal transduction GO:0060395
The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.
1 Q921I1 (/IDA)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
1 P02787 (/TAS)
Antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844
An immune response against microbes mediated by anti-microbial peptides in body fluid.
1 P08071 (/ISO)
ERK1 and ERK2 cascade GO:0070371
An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
1 Q921I1 (/IDA)
Positive regulation of oligodendrocyte progenitor proliferation GO:0070447
Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation.
1 P12346 (/IDA)
Positive regulation of oligodendrocyte progenitor proliferation GO:0070447
Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation.
1 Q921I1 (/ISO)
Cellular response to iron ion GO:0071281
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
1 P02787 (/IGI)
Cellular response to iron ion GO:0071281
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
1 Q921I1 (/ISO)
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
1 P12346 (/IEP)
Cellular response to follicle-stimulating hormone stimulus GO:0071372
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus.
1 P12346 (/IEP)
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
1 P08071 (/ISO)
Negative regulation of single-species biofilm formation in or on host organism GO:1900229
Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation in or on host organism.
1 P08071 (/ISO)
Positive regulation of chondrocyte proliferation GO:1902732
Any process that increases the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.
1 P08071 (/ISO)
Negative regulation of cysteine-type endopeptidase activity GO:2000117
Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity.
1 P08071 (/ISO)
Positive regulation of cell motility GO:2000147
Any process that activates or increases the frequency, rate or extent of cell motility.
1 Q921I1 (/IDA)

There are 66 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Specific granule GO:0042581
Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
9 O77698 (/ISS) O77811 (/ISS) P08071 (/ISS) P14632 (/ISS) P24627 (/ISS) P24627 (/ISS) P24627 (/ISS) Q29477 (/ISS) Q9TUM0 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
6 P02788 (/IDA) P02788 (/IDA) P12346 (/IDA) P24627 (/IDA) P24627 (/IDA) P24627 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 P02787 (/TAS) P02788 (/TAS) P02788 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 P02787 (/HDA) P02788 (/HDA) P02788 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 B7ZAL5 (/HDA) P02788 (/HDA) P02788 (/HDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
3 P02787 (/IDA) P02788 (/IDA) P02788 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 P02787 (/HDA) P02788 (/HDA) P02788 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P08071 (/ISO) Q921I1 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P02788 (/IMP) P02788 (/IMP)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
2 P02787 (/IDA) Q921I1 (/IDA)
Clathrin-coated pit GO:0005905
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
2 P02787 (/IDA) Q921I1 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P08071 (/ISO) Q921I1 (/ISO)
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
2 P02787 (/IDA) Q921I1 (/IDA)
Secretory granule GO:0030141
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
2 P02788 (/IDA) P02788 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 P02788 (/IDA) P02788 (/IDA)
Specific granule lumen GO:0035580
The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
2 P02788 (/TAS) P02788 (/TAS)
Specific granule GO:0042581
Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
2 P02788 (/IDA) P02788 (/IDA)
Other organism cell membrane GO:0044218
The cell membrane of a secondary organism with which the first organism is interacting.
2 P02788 (/IMP) P02788 (/IMP)
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
2 P02787 (/IDA) Q921I1 (/IDA)
Phagocytic vesicle lumen GO:0097013
The volume enclosed by the membrane of a phagocytic vesicle.
2 P02788 (/TAS) P02788 (/TAS)
Tertiary granule lumen GO:1904724
Any membrane-enclosed lumen that is part of a tertiary granule.
2 P02788 (/TAS) P02788 (/TAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P02787 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q921I1 (/ISO)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P02787 (/NAS)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
1 P12346 (/IDA)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
1 Q921I1 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P08071 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P08071 (/ISO)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 Q921I1 (/IDA)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
1 Q921I1 (/ISO)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
1 P02787 (/IDA)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
1 Q921I1 (/ISO)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
1 P02787 (/TAS)
Clathrin-coated pit GO:0005905
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
1 Q921I1 (/ISO)
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 P02787 (/IDA)
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 Q921I1 (/ISO)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
1 P02787 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q921I1 (/IMP)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 P02787 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q921I1 (/ISO)
Vesicle coat GO:0030120
A membrane coat found on a coated vesicle.
1 Q921I1 (/ISO)
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
1 Q921I1 (/ISO)
Secretory granule GO:0030141
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
1 P08071 (/ISO)
Clathrin-coated vesicle membrane GO:0030665
The lipid bilayer surrounding a clathrin-coated vesicle.
1 P02787 (/TAS)
Extrinsic component of external side of plasma membrane GO:0031232
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.
1 P02787 (/IGI)
Extrinsic component of external side of plasma membrane GO:0031232
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.
1 Q921I1 (/ISO)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 P02787 (/IDA)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 Q921I1 (/ISO)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
1 P02787 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
1 Q921I1 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P08071 (/ISO)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
1 P02787 (/TAS)
Specific granule GO:0042581
Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
1 P08071 (/ISO)
Other organism cell membrane GO:0044218
The cell membrane of a secondary organism with which the first organism is interacting.
1 P08071 (/ISO)
Basal part of cell GO:0045178
The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.
1 P02787 (/IDA)
Basal part of cell GO:0045178
The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.
1 Q921I1 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P02787 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q921I1 (/ISO)
Cell tip GO:0051286
The region at the end of the longest axis of a cylindrical or elongated cell.
1 P12346 (/IDA)
Cell tip GO:0051286
The region at the end of the longest axis of a cylindrical or elongated cell.
1 Q921I1 (/ISO)
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
1 Q921I1 (/ISO)
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
1 P02787 (/HDA)
Dense body GO:0097433
An electron dense body which may contain granules.
1 Q06AH7 (/IDA)
Dense body GO:0097433
An electron dense body which may contain granules.
1 Q921I1 (/ISO)
HFE-transferrin receptor complex GO:1990712
A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.
1 P02787 (/IDA)
HFE-transferrin receptor complex GO:1990712
A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.
1 Q921I1 (/ISO)