# STOCKHOLM 1.0
#=GF ID 3.30.65.10/FF/000008
#=GF DE DNA topoisomerase I
#=GF AC 3.30.65.10/FF/000008
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 90.426
#=GS Q9LVP1/625-676      AC Q9LVP1
#=GS Q9LVP1/625-676      OS Arabidopsis thaliana
#=GS Q9LVP1/625-676      DE DNA topoisomerase 3-alpha
#=GS Q9LVP1/625-676      DR ORG; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Brassicales; Brassicaceae; Camelineae; Arabidopsis; Arabidopsis thaliana; 
#=GS Q9LVP1/625-676      DR GO; GO:0000278; GO:0000712; GO:0006281; GO:0007059; GO:0051321; 
#=GS Q9LVP1/625-676      DR EC; 5.6.2.2; 
#=GS Q2GG85/591-637      AC Q2GG85
#=GS Q2GG85/591-637      OS Ehrlichia chaffeensis str. Arkansas
#=GS Q2GG85/591-637      DE DNA topoisomerase 1
#=GS Q2GG85/591-637      DR ORG; Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Anaplasmataceae; Ehrlichia; canis group; Ehrlichia chaffeensis; 
#=GS Q2GG85/591-637      DR GO; GO:0006268; 
#=GS Q8TPW5/594-648      AC Q8TPW5
#=GS Q8TPW5/594-648      OS Methanosarcina acetivorans C2A
#=GS Q8TPW5/594-648      DE DNA topoisomerase, type I
#=GS Q8TPW5/594-648      DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina acetivorans; 
#=GS A0A1D6JPQ3/624-678  AC A0A1D6JPQ3
#=GS A0A1D6JPQ3/624-678  OS Zea mays
#=GS A0A1D6JPQ3/624-678  DE DNA topoisomerase
#=GS A0A1D6JPQ3/624-678  DR ORG; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Liliopsida; Petrosaviidae; Poales; Poaceae; Panicoideae; Andropogoneae; Tripsacinae; Zea; Zea mays; 
#=GS A0A0E3SNS0/598-652  AC A0A0E3SNS0
#=GS A0A0E3SNS0/598-652  OS Methanosarcina barkeri 3
#=GS A0A0E3SNS0/598-652  DE DNA topoisomerase I
#=GS A0A0E3SNS0/598-652  DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina barkeri; 
#=GS A0A0E3NPL6/632-686  AC A0A0E3NPL6
#=GS A0A0E3NPL6/632-686  OS Methanosarcina sp. WH1
#=GS A0A0E3NPL6/632-686  DE DNA topoisomerase I
#=GS A0A0E3NPL6/632-686  DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina sp. WH1; 
#=GS A0A0E3L2I7/632-686  AC A0A0E3L2I7
#=GS A0A0E3L2I7/632-686  OS Methanosarcina sp. WWM596
#=GS A0A0E3L2I7/632-686  DE DNA topoisomerase I
#=GS A0A0E3L2I7/632-686  DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina sp. WWM596; 
#=GS A0A0E3NV86/594-648  AC A0A0E3NV86
#=GS A0A0E3NV86/594-648  OS Methanosarcina sp. MTP4
#=GS A0A0E3NV86/594-648  DE DNA topoisomerase I
#=GS A0A0E3NV86/594-648  DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina sp. MTP4; 
#=GS A0A0E3S7M6/594-648  AC A0A0E3S7M6
#=GS A0A0E3S7M6/594-648  OS Methanosarcina lacustris Z-7289
#=GS A0A0E3S7M6/594-648  DE DNA topoisomerase I
#=GS A0A0E3S7M6/594-648  DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina lacustris; 
#=GS A0A1E7GC71/594-649  AC A0A1E7GC71
#=GS A0A1E7GC71/594-649  OS Methanosarcina sp. Ant1
#=GS A0A1E7GC71/594-649  DE DNA topoisomerase
#=GS A0A1E7GC71/594-649  DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina sp. Ant1; 
#=GS A0A0E3RJC1/594-647  AC A0A0E3RJC1
#=GS A0A0E3RJC1/594-647  OS Methanosarcina mazei S-6
#=GS A0A0E3RJC1/594-647  DE DNA topoisomerase I
#=GS A0A0E3RJC1/594-647  DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina mazei; 
#=GS A0A0E3LHR5/618-672  AC A0A0E3LHR5
#=GS A0A0E3LHR5/618-672  OS Methanosarcina vacuolata Z-761
#=GS A0A0E3LHR5/618-672  DE DNA topoisomerase I
#=GS A0A0E3LHR5/618-672  DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina vacuolata; 
#=GS R0GNU4/626-676      AC R0GNU4
#=GS R0GNU4/626-676      OS Capsella rubella
#=GS R0GNU4/626-676      DE DNA topoisomerase
#=GS R0GNU4/626-676      DR ORG; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Brassicales; Brassicaceae; Camelineae; Capsella; Capsella rubella; 
#=GS D7MQJ2/625-676      AC D7MQJ2
#=GS D7MQJ2/625-676      OS Arabidopsis lyrata subsp. lyrata
#=GS D7MQJ2/625-676      DE DNA topoisomerase
#=GS D7MQJ2/625-676      DR ORG; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Brassicales; Brassicaceae; Camelineae; Arabidopsis; Arabidopsis lyrata; Arabidopsis lyrata subsp. lyrata; 
#=GS A0A1B6QQB9/678-732  AC A0A1B6QQB9
#=GS A0A1B6QQB9/678-732  OS Sorghum bicolor
#=GS A0A1B6QQB9/678-732  DE DNA topoisomerase
#=GS A0A1B6QQB9/678-732  DR ORG; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Liliopsida; Petrosaviidae; Poales; Poaceae; Panicoideae; Andropogoneae; Sorghinae; Sorghum; Sorghum bicolor; 
#=GS Q8Q0F3/594-647      AC Q8Q0F3
#=GS Q8Q0F3/594-647      OS Methanosarcina mazei Go1
#=GS Q8Q0F3/594-647      DE DNA topoisomerase III
#=GS Q8Q0F3/594-647      DR ORG; Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina; Methanosarcina mazei; 
#=GF SQ 16
Q9LVP1/625-676              NNTDESESQTAGEVVRRCNLCNESDMALRKNRDGNFMVGCMNYPQCRNAVWL------
Q2GG85/591-637              -------SSDKSESSRVCPVCNDGTLELNISKNGIF-LGCSKYPECKYTKNV-GSG--
Q8TPW5/594-648              TIKDEAALEDKKNYIGTCKACGH-VLRIVQTDTGRF-VGCTGYPDCRNSFPLPKTGA-
A0A1D6JPQ3/624-678          -NRPINETQNPVEVVRPCGACNGSEMLLKRRASGEFMVGCRSYPQCRNVVWLPGSL--
A0A0E3SNS0/598-652          TIKDEAALEDKKNYIGTCKACGH-VLRIVQTDSGRF-VGCTGYPDCRNSYPLPKSGA-
A0A0E3NPL6/632-686          TIKDEAALEDKKNYIGTCKACGH-VLKIVQTDTGRF-VGCTGYPDCRNSFPLPKTGA-
A0A0E3L2I7/632-686          TIKDEAALEDKKNYIGTCKACGH-VLKIVQTDTGRF-VGCTGYPDCRNSFPLPKTGA-
A0A0E3NV86/594-648          TIKDEAALEDKKNLIGTCPECGH-VLHIVQTDSGRF-VGCTGYPDCRNSYPLPKTGA-
A0A0E3S7M6/594-648          TIKDEAALEDKKNYIGTCKVCGH-VLKIVQTDTGRF-VGCSGYPDCRNSFPLPKTGA-
A0A1E7GC71/594-649          TIKDEAALEDKKNYIGTCKACGH-VLKIVQTDSGRF-VGCTGYPDCRNSYPLPKTGAL
A0A0E3RJC1/594-647          TIKDEAALEDKKNYIGTCKACGH-VLRIIQTDSGRF-VGCTGYPDCRNSFSLPKTG--
A0A0E3LHR5/618-672          TIKDEAALEDKKNYIGTCKVCGH-VLRIVQTDSGRF-VGCTGYPDCRNSYPLPKAGA-
R0GNU4/626-676              -NTDEGENQTAGEVVRRCNLCNESDMALRKNRDGNFMVGCMNYPQCRNAVWL------
D7MQJ2/625-676              NNTDESESQTAGEVIRRCNLCNESDMALRKNRDGNFMVGCMNYPQCRNAVWL------
A0A1B6QQB9/678-732          -NRPINETQNPVEVVRPCGACNGSEMVLKRRVTGEFMVGCRSYPQCRNVVWLPGSL--
Q8Q0F3/594-647              TIKDEAALEDKKNYIGTCKACGH-VLRIIQTDSGRF-VGCTGYPDCRNSFSLPKTG--
#=GC scorecons              2445544455436465494495414636354449491899449959874438333310
#=GC scorecons_70           _________________*__*____*_*_____*_*_***__**_***___*______
#=GC scorecons_80           _________________*__*____________*_*_***__**_***___*______
#=GC scorecons_90           _________________*__*____________*_*__**__**_**___________
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