The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Poxvirus poly(A) polymerase, nucleotidyltransferase domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Poxvirus poly(A) polymerase, nucleotidyltransferase domain

Poly(A) polymerase (EC: catalyses template-independent extension of the 3'-end of a DNA or RNA strand by one nucleotide at a time. The Poxvirus enzyme creates the 3'(poly)A tail of mRNAs, and is a heterodimer composed of a catalytic (VP55) and a regulatory subunit (VP39).

VP55 comprises three domains: the N-terminal or N domain, the central or catalytic domain, and the C-terminal or C domain, all three domains having distinct topologies. The core comprises a mixed nine-stranded twisted beta sheet, with the first seven strands being folded from one long (118 residue) polypeptide segment that follows the N domain and the last two strands originating from the extreme C-terminal-most 15 residues of the entire polypeptide chain. Of the four alpha-helices in the catalytic domain, the two longest (J and L) near the surface pack against one side of the beta-sheet in a nearly parallel orientation to the beta-strands.

This superfamily entry represents the nucleotidyltransferase (central) domain of the catalytic subunit VP55 PMID:16678106.

INTERPRO:IPR024231, PFAM:PF03296,DOI:10.1016/j.molcel.2006.03.015

GO Diversity

Unique GO annotations
0 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
65 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 9
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 6
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 1
Unique GO:
Unique Species: 65