# STOCKHOLM 1.0
#=GF ID 3.20.20.70/FF/000221
#=GF DE tRNA-dihydrouridine synthase
#=GF AC 3.20.20.70/FF/000221
#=GF TP FunFam
#=GF DR CATH: v4.3
#=GF DR DOPS: 89.665
#=GS Q583Y8/61-290      AC Q583Y8
#=GS Q583Y8/61-290      OS Trypanosoma brucei brucei TREU927
#=GS Q583Y8/61-290      DE tRNA-dihydrouridine synthase 4, putative
#=GS Q583Y8/61-290      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma brucei; Trypanosoma brucei brucei; 
#=GS Q583Y8/61-290      DR GO; GO:0005737; GO:0005929; GO:0031981; GO:0097014; 
#=GS Q9VJ06/24-256      AC Q9VJ06
#=GS Q9VJ06/24-256      OS Drosophila melanogaster
#=GS Q9VJ06/24-256      DE LD05576p
#=GS Q9VJ06/24-256      DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster; 
#=GS Q09504/1-230       AC Q09504
#=GS Q09504/1-230       OS Caenorhabditis elegans
#=GS Q09504/1-230       DE Uncharacterized tRNA-dihydrouridine synthase-like protein C45G9.2
#=GS Q09504/1-230       DR ORG; Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis; Caenorhabditis elegans; 
#=GS A2DHB4/11-254      AC A2DHB4
#=GS A2DHB4/11-254      OS Trichomonas vaginalis
#=GS A2DHB4/11-254      DE Uncharacterized protein
#=GS A2DHB4/11-254      DR ORG; Eukaryota; Trichomonadida; Trichomonadidae; Trichomonas; Trichomonas vaginalis; 
#=GS Q4Q391/96-349      AC Q4Q391
#=GS Q4Q391/96-349      OS Leishmania major
#=GS Q4Q391/96-349      DE Uncharacterized protein
#=GS Q4Q391/96-349      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania major species complex; Leishmania major; 
#=GS A0A1G4I5G3/61-290  AC A0A1G4I5G3
#=GS A0A1G4I5G3/61-290  OS Trypanosoma equiperdum
#=GS A0A1G4I5G3/61-290  DE tRNA-dihydrouridine synthase 4, putative
#=GS A0A1G4I5G3/61-290  DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Trypanosoma; Trypanozoon; Trypanosoma equiperdum; 
#=GS E9B4T5/96-349      AC E9B4T5
#=GS E9B4T5/96-349      OS Leishmania mexicana MHOM/GT/2001/U1103
#=GS E9B4T5/96-349      DE Uncharacterized protein
#=GS E9B4T5/96-349      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania mexicana species complex; Leishmania mexicana; 
#=GS A0A3Q8IN46/96-349  AC A0A3Q8IN46
#=GS A0A3Q8IN46/96-349  OS Leishmania donovani
#=GS A0A3Q8IN46/96-349  DE Dihydrouridine synthase (Dus), putative
#=GS A0A3Q8IN46/96-349  DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania donovani; 
#=GS H3FIF8/20-253      AC H3FIF8
#=GS H3FIF8/20-253      OS Pristionchus pacificus
#=GS H3FIF8/20-253      DE Uncharacterized protein
#=GS H3FIF8/20-253      DR ORG; Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Diplogasteromorpha; Diplogasteroidea; Neodiplogasteridae; Pristionchus; Pristionchus pacificus; 
#=GS A4I9S4/96-349      AC A4I9S4
#=GS A4I9S4/96-349      OS Leishmania infantum
#=GS A4I9S4/96-349      DE Dihydrouridine_synthase_(Dus)_-_putative
#=GS A4I9S4/96-349      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania infantum; 
#=GS A0A2G5UL86/14-253  AC A0A2G5UL86
#=GS A0A2G5UL86/14-253  OS Caenorhabditis nigoni
#=GS A0A2G5UL86/14-253  DE tRNA-dihydrouridine synthase
#=GS A0A2G5UL86/14-253  DR ORG; Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis; Caenorhabditis nigoni; 
#=GS A8Y3E7/3-246       AC A8Y3E7
#=GS A8Y3E7/3-246       OS Caenorhabditis briggsae
#=GS A8Y3E7/3-246       DE tRNA-dihydrouridine synthase
#=GS A8Y3E7/3-246       DR ORG; Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis; Caenorhabditis briggsae; 
#=GS E9BQS3/96-349      AC E9BQS3
#=GS E9BQS3/96-349      OS Leishmania donovani BPK282A1
#=GS E9BQS3/96-349      DE Uncharacterized protein
#=GS E9BQS3/96-349      DR ORG; Eukaryota; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania; Leishmania; Leishmania donovani species complex; Leishmania donovani; 
#=GS B4Q9F7/24-257      AC B4Q9F7
#=GS B4Q9F7/24-257      OS Drosophila simulans
#=GS B4Q9F7/24-257      DE GD24181
#=GS B4Q9F7/24-257      DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila simulans; 
#=GS B4PAG2/25-259      AC B4PAG2
#=GS B4PAG2/25-259      OS Drosophila yakuba
#=GS B4PAG2/25-259      DE Uncharacterized protein
#=GS B4PAG2/25-259      DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila yakuba; 
#=GS A0A1W4VXS5/25-257  AC A0A1W4VXS5
#=GS A0A1W4VXS5/25-257  OS Drosophila ficusphila
#=GS A0A1W4VXS5/25-257  DE tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like
#=GS A0A1W4VXS5/25-257  DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; ficusphila subgroup; Drosophila ficusphila; 
#=GS B3NMA0/25-257      AC B3NMA0
#=GS B3NMA0/25-257      OS Drosophila erecta
#=GS B3NMA0/25-257      DE Uncharacterized protein
#=GS B3NMA0/25-257      DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila erecta; 
#=GS B4I5Q7/24-257      AC B4I5Q7
#=GS B4I5Q7/24-257      OS Drosophila sechellia
#=GS B4I5Q7/24-257      DE tRNA-dihydrouridine synthase
#=GS B4I5Q7/24-257      DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila sechellia; 
#=GS A2FU21/15-254      AC A2FU21
#=GS A2FU21/15-254      OS Trichomonas vaginalis
#=GS A2FU21/15-254      DE Uncharacterized protein
#=GS A2FU21/15-254      DR ORG; Eukaryota; Trichomonadida; Trichomonadidae; Trichomonas; Trichomonas vaginalis; 
#=GS A2EF32/16-259      AC A2EF32
#=GS A2EF32/16-259      OS Trichomonas vaginalis
#=GS A2EF32/16-259      DE tRNA-dihydrouridine synthase
#=GS A2EF32/16-259      DR ORG; Eukaryota; Trichomonadida; Trichomonadidae; Trichomonas; Trichomonas vaginalis; 
#=GS A2EN54/12-251      AC A2EN54
#=GS A2EN54/12-251      OS Trichomonas vaginalis
#=GS A2EN54/12-251      DE Uncharacterized protein
#=GS A2EN54/12-251      DR ORG; Eukaryota; Trichomonadida; Trichomonadidae; Trichomonas; Trichomonas vaginalis; 
#=GF SQ 21
Q583Y8/61-290              -----KIQAPMVRCSRPAFRKLCRLWGTDISYTHMIMADSFACSEAARQAE--FSIYSGETRLITQLASSSGPT--AATAAAIVAPWCDAIDLNCGCPQRRVMADGLGAALLRNPEVVADTVRCVRNALEGGVE---------------------LPCVVKMRV------KDDVRLSVDFARQCEAAGAAWITVHGRTPNC-SAHAPVRFDAINTIREALGVPVVANGGVRDPSTALQAALTAGVGGVMSGMGLLANPACFYVPGAD-------------------------
Q9VJ06/24-256              ----VRVSAPMVRYSKLEFRRLVRLNGVQLAFTPMMISDSINNSEKARQNE--FSTGADDQPLIAQFAAKDPTE--FVTSAQLIYPYVDGIDLNCGCPQSWAMAKGYGCGMLRQPELVHQVVQEVRRTLP-GD----------------------FSVSVKMRLLG---GEESLQRTIDLARQLESAGVTFLTLHGRTPAQKHSKDTLDIPAMSQVRQSLQIPLIVNGNVESYRDACDMHEQTGAAGVMAARGLLANPALFNSNYPD-------------------------
Q09504/1-230               ----------MVRYSKLAFRQLVRVYDVDVCFTPMIYAKNFIESEKCRSSE--LSVCEGDSPLIVQFATDDPFV--LSEAAEMVYKCSTGVDLNCGCPKHDVRSKGFGSALLSKPELLADMVRQTRARIPDPD----------------------FSVSLKIRI------NHDIEKTVDLCRKAEAAGVTHLTVHGRTPSQ--RAEPIDIQALRIVKDSVSVPIIANGGITTREEALFLAEQTGVDGIMAANGLLDNPALFAGHEHTPSDCVEN------------------
A2DHB4/11-254              -RESIIFLAPMADVNDYSFRKLCRQNGVSLCWTGFINAHHWVTRTKQRDRDVWFTTRDNEKNLVVQLLGSNLEE--LVSCAKDVENFCDMIELNCGCTHCFASRSGCGFFLIDTQKHRDSALILIQNLIKSIN----------------------KPVSIKIRLISDDNSVPSLERTVKFAQDLERVGVSLITVHARTQQA-DKKGDVDYDAIKAVVQAVSVPVIANGGISSLEQAQEIIQRTGAYAVMAGQCFFKNPTCLTTN-KNPKEI---------------------
Q4Q391/96-349              ---LCLIQAPMVRCSRPAFRQVCRAWGTRVSYTHMLMAESFVKSPHARHAE--FARYEGENRLVAQLAAKSGPA--AAQAALLLRPYCDGIDLNCGCPQRWAMKEGIGAALLDQPERVADMVRSIRNAMPDGSTAPMIVGNGGEYSSCTSAVPPFLPCVVKMRI------KDDLRRSVDFARQCEAAGVSWLTVHGRTPTC-HSSTAVQFEAVKLIRENLSVPVVLNGGVTDVSTAMEAALRTGCGGLMSANGLLDNPAMFYCGASRA------------------------
A0A1G4I5G3/61-290          -----KIQAPMVRCSRPAFRKLCRLWGTDISYTHMIMADSFACSEAARQAE--FSIYSGETRLITQLASSSGPT--AATAAAIVAPWCDAIDLNCGCPQRRVMADGLGAALLRNPEVVADTVRCVRNALEGGVE---------------------LPCVVKMRV------KDDVRLSVDFARQCEAAGAAWITVHGRTPNC-SAHAPVRFDAINTIREALGVPVVANGGVRDPSTALQAALTAGVGGVMSGMGLLANPACFYVPGAD-------------------------
E9B4T5/96-349              ---LCLIQAPMVRCSRPAFRQVCRAWGTRVSYTHMLIAESFVKSPHARHAE--FARYEGEDRLVVQLAAKSGPA--AAQAALLLRPYCDGIDLNCGCPQRWAMKEGIGAALLDQPERVADIVRSIRNAMPDGSTAPTIVGNGGEHSSCTSAAPPFLPCVVKMRI------KDDLRRSVDFARQCEAAGVSWLTVHGRTPTC-HPSAAVQFEAVKLIRENLSVPVVLNGGVTDVSTAMEAALRTGCGGLMSANGLLDNPAMFYCGASRA------------------------
A0A3Q8IN46/96-349          ---LCLIQAPMVRCSRPAFRQVCRAWGARVSYTHMLIAESFVKSPHARHAE--FARYEGEDRLVVQLAAKSGPA--AAQAAVLLRPYCDGIDLNCGCPQRWAMKEGIGSALLDQPERVADMVRSIRNAMPDGSTASTIVGNGCEYGSCTSTVPPFLPCVVKMRI------KDDLRRSVDFARQCEAAGVSWLTVHGRTPTC-HPSAAVQFEAVKLIRENLSVPVVLNGGVTDVSTAMEAALRTGCGGLMSANGLLDNPAMFYCGASRA------------------------
H3FIF8/20-253              ---PLYYCAPMVRYSKLAFRNLVRRHGVDVAFSPMIYARNFLESEHARVSE--FATHPDDKQTIVQFAANEPEV--FAAAAELVYPYSVGVDLNCGCPKSDVRQKGFGSSLLNKPELLADIVRQTRARISDPD----------------------YKVSLKIRV------HYPLDQTIDLCRKAEAAGVSHLTVHGRTPSM--RCEPVDYDAIRTIVDAVNVPVIANGDIRSLEDANTVSSHTGCTGVMAANGLLANPSFFNGDETTSAQC---------------------
A4I9S4/96-349              ---LCLIQAPMVRCSRPAFRQVCRAWGARVSYTHMLIAESFVKSPHARHAE--FARYEGEDRLVVQLAAKSGPA--AAQAAVLLRPYCDGIDLNCGCPQRWAMKEGIGSALLDQPERVADMVRSIRNAMPDGSTASTIVGNGCEYGSCTSTVPPFLPCVVKMRI------KDDLRRSVDFARQCEAAGVSWLTVHGRTPTC-HPSAAVQFEAVKLIRENLSVPVVLNGGVTDVSTAMEAALRTGCGGLMSANGLLDNPAMFYCGASRA------------------------
A0A2G5UL86/14-253          NKRPKFYLAPMVRYSKLAFRQLVRLYDVDVCYTPMIYAKNFIESEKCRNSE--LSVCAGDSPLIVQFATDDPFV--LAEAAEMVYSCSSGVDLNCGCPKHDVRSKGFGSALLSKPELLADMVRQTRARISDEN----------------------FSVSLKIRV------NKEIERTVDLCRKAESAGVTHLTVHGRTPSQ--HAEPIDIEAIRIVKSSVRVPIIANGGITNLQEAMDLAEKTGVDGIMAANGLLDNPALFAGYEYTPSDCVEN------------------
A8Y3E7/3-246               --------------YRLAFRQLVRLYDVDVCYTPMIYAKNFIESEKCRNSE--LSVCEGDSPLIVQFATDDPFV--LAEAAEMVYSCSSGVDLNCGCPKHDVRSKGFGSALLSKPELLADMVRQTRARISDEN----------------------FSVSLKIRV------NKEIEKTVDLCRKAESAGVTHLTVHGRTPSQ--HAEPIDIEAIRLVKSAVKVPIIANGGITNLQEAMNLAEKTGVDGIMAANGLLDNPALFAGYEYTPSDCVESFMRLSREHGLDWLLYHQH
E9BQS3/96-349              ---LCLIQAPMVRCSRPAFRQVCRAWGARVSYTHMLIAESFVKSPHARHAE--FARYEGEDRLVVQLAAKSGPA--AAQAAVLLRPYCDGIDLNCGCPQRWAMKEGIGSALLDQPERVADMVRSIRNAMPDGSTASTIVGNGCEYGSCTSTVPPFLPCVVKMRI------KDDLRRSVDFARQCEAAGVSWLTVHGRTPTC-HPSAAVQFEAVKLIRENLSVPVVLNGGVTDVSTAMEAALRTGCGGLMSANGLLDNPAMFYCGASRA------------------------
B4Q9F7/24-257              ----VRVSAPMVRYSKLEFRRLVRLNGVQLAFTPMMISDSINNSEKARQNE--FSTGADDQPLIAQFAAKDPTE--FVTSAQLIYPYVDGIDLNCGCPQSWAMAKGYGCGMLRQPELVHQVVQEVRRTLP-GD----------------------FSVSVKMRLLG---GEESLQRTIDLARQLEHAGVTFLTLHGRTPAQKHSKDTLDIPSMSQVRQSLQIPLIVNGNVESYRDACDMHEQTGAAGVMAARGLLANPALFNRSYPEG------------------------
B4PAG2/25-259              -----RVSAPMVRYSKLEFRRLVRLNGVQLAFTPMMISDSINNSEKARQNE--FSTGADDQPLIAQFAAKDPTE--FVTSAQLIYPYVDGIDLNCGCPQSWAMAKGYGCGMLRQPELVRQVVQEVRRALP-AD----------------------FSVSVKMRLLG---GEQSLERTIDLARQLEQAGVTFLTLHGRTPAQKHSKDTLDIPAMAEVRKSLQIPLIVNGNVESYRDACDMHDQTGAAGVMAARGLLANPALFNSIYPDAKT----------------------
A0A1W4VXS5/25-257          -----RVSAPMVRYSKLEFRRLVRLNGVQLAFTPMMISDSINNSEKARQNE--FSTGADDQPLIAQFAAKDPSE--FVTSAQLIYPYVDGIDLNCGCPQSWAISKGYGCGMLRQPELVRQVVQEVRRTFP-TD----------------------FSVSVKMRLLG---GEDSLERTIDLARQLEHAGVTFLTLHGRTPAQKHSKDTLDIPAMSEVRQSLRIPLIVNGNVETYKDACDLHEQTGAAGVMAARGLLANPALFNSAYPDS------------------------
B3NMA0/25-257              -----RVSAPMVRYSKLEFRRLVRLNGVQLAFTPMMISDSINNSEKARQNE--FSTGADDQPLIAQFAAKDPTE--FVTSAQLIYPYVDGIDLNCGCPQSWAMAKGYGCGMLRQPELVRQVVQEVRRTLP-AD----------------------FSVSVKMRLLG---GEKSLESTIDLARQLEQAGVTFLTLHGRTPAQKHSKDTLDIAAMAEVRKSLQIPLIVNGNVESYRDACDIHDQTGAAGVMAARGLLANPALFNSNYPEG------------------------
B4I5Q7/24-257              ----VRVSAPMVRYSKLEFRRLVRLNGVQLAFTPMMISDSINNSEKARQNE--FSTGADDQPLIAQFAAKDPTE--FVTSAQLIYPYVDGIDLNCGCPQSWAMAKGYGCGMLRQPELVHQVVQEVRRTLP-GD----------------------FSVSVKMRLLG---GEESLQRTIDLARQLEHAGVTFLTLHGRTPAQKHSKDTLDIPAMSQVRQSLQIPLIVNGNVESYRDACDMHEQTGAAGVMAARGLLANPALFNSSYPEG------------------------
A2FU21/15-254              --EVPIVLAPQFEVNDLAFRMLVRKYNVKLCWTGMVNSHMWAIQPSSRNSY--FQTCSQDRPLIIQMSGNDESE--LIACAKDLQQFAVGIDINCGCTQHIARRGQYGYFMVNNENKRKNVIEMVKNIVASIN----------------------VPLSIKFRLIDGEDGKPDVDITCKFAKELEDAGVSLISVHGRAKNS-NKAGPVDAEAIRKIAESVSIPVMANGGVRTKEEAIEMFKESHAAGVMVGQGLLMNPKAFSDTPEHDP-----------------------
A2EF32/16-259              -GEKPICLAPMAEISDLSWRMLIRNHGVKVCWTGMLNAHQWSQGSGYQNKF--FNTCPEDHPLIAQIAGSNEDQDLIVAAAKDLAKYADGVDVNLGCTQKIASRSEYGYFMVDNCQKREKTLELFRRLCKEVN----------------------CPICAKIRIFIDDSGEVSEKITIDFAKKLEEAGVSLLQVHGRAEHR-NKQADVYNEIIKHIVQAVNIPVVANGGINTVEDAHKFMEETGAAGVSVAQALLKDPTAFDPTGKKPRK----------------------
A2EN54/12-251              --EYPVCLAPMVEMGDIAFRILCHRHGCDVCWTGMINGSQWNRSKTYRQQQ--IEYSEEDRPLVIQISGSIDVD--LLTTAKSMSEFGVPIDINLGCCQKVAKRGEYGYFMVDSEQKRQNVVNLIKSIPSEIT----------------------VPLYVKIRALTDESGIPSIPITVDFAKHLEEAGASLITIHGRSAAQ-DKHGPLNKELVKAVVQAVSIPVIVNGGINSLDDARNMIRETGAIAAMSAQSLLMDPTLFDKNGRQPN-----------------------
#=GC scorecons             0001123377765365558947583365464584854645443644484460074434573587595754443400454593453564567879799664364447494467446634455753574444334000000000000000000000045456969510000143554466766754948975377698976440333446545764374556479665996744344934443478447685747884796483332333000000000000000000000000
#=GC scorecons_70          ________****__*___**_*_*__*_____*_*________*___*_____*_____*__**_*_*____________*________**********__*___*_*__**___*_____*___*__________________________________***_____________******__*_***__********____________*___*___*_****_****_____*______**__*_*_*_***_***_*_______________________________
#=GC scorecons_80          __________*_______**_*_*________*_*____________*___________*__**_*______________*_________*******__________*_____________*___*__________________________________*_*_______________*__*__*_***___*_****________________________*___**_*_____*______**__*_*____**_**__*_______________________________
#=GC scorecons_90          __________________**___*________*_*____________*______________*__*______________*__________*_*_**__________*____________________________________________________*_*_____________________*_**______***_________________________*___**_______*_______*____*____**__*__*_______________________________
//