The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

ArcTGT, C2 domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: ArcTGT, C2 domain

This superfamily includes the Archaeosine tRNA-guanine transglycosylase (ArcTGT), domain C2. The ArcTGT structure consists of the N-terminal catalytic domain (residues 6-360) and the C-terminal region with unidentified functions (residues 361-582) (Figure 3). The C-terminal region is divided into three domains, C1, C2, and C3. This entry represents domain C2 which is formed by a four-stranded antiparallel beta-sheet lined with two alpha-helices. It has conserved basic residues on the surface of the beta-sheets as does the C-terminal domain PUA (INTERPRO:IPR002478, PFAM:PF01472). The catalytic domain of TGT has conserved basic residues on the outer surface of the N-terminal three-stranded beta sheet, which closes the barrel. It is postulated that these basic residues from the three domains form a continuous, positively charged patch to which the tRNA binds PMID:12054814.

PFAM:PF14810, INTERPRO:IPR029402,DOI:10.1016/S0022-2836(02)00090-6

GO Diversity

Unique GO annotations
0 Unique GO terms

EC Diversity

Unique EC annotations
2 Unique EC terms

Species Diversity

Unique species annotations
576 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 9
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 5
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 2
Unique GO:
Unique Species: 576