# STOCKHOLM 1.0 #=GF ID 2.60.40.150/FF/000199 #=GF DE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma #=GF AC 2.60.40.150/FF/000199 #=GF TP FunFam #=GF DR CATH: v4.3 #=GF DR DOPS: 85.312 #=GS Q22070/1107-1259 AC Q22070 #=GS Q22070/1107-1259 OS Caenorhabditis elegans #=GS Q22070/1107-1259 DE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3 #=GS Q22070/1107-1259 DR ORG; Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis; Caenorhabditis elegans; #=GS Q22070/1107-1259 DR GO; GO:0030431; #=GS Q22070/1107-1259 DR EC; 3.1.4.11; #=GS Q9VXH3/1102-1235 AC Q9VXH3 #=GS Q9VXH3/1102-1235 OS Drosophila melanogaster #=GS Q9VXH3/1102-1235 DE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma #=GS Q9VXH3/1102-1235 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster; #=GS Q9VXH3/1102-1235 DR GO; GO:0007298; GO:0030307; GO:0032868; GO:0042059; GO:0045596; GO:0045677; GO:0045873; GO:0070373; #=GS Q7QHE3/1097-1232 AC Q7QHE3 #=GS Q7QHE3/1097-1232 OS Anopheles gambiae #=GS Q7QHE3/1097-1232 DE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma #=GS Q7QHE3/1097-1232 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles gambiae; #=GS A7SMY6/526-658 AC A7SMY6 #=GS A7SMY6/526-658 OS Nematostella vectensis #=GS A7SMY6/526-658 DE Phosphoinositide phospholipase C #=GS A7SMY6/526-658 DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; #=GS W4XRL3/339-503 AC W4XRL3 #=GS W4XRL3/339-503 OS Strongylocentrotus purpuratus #=GS W4XRL3/339-503 DE Phosphoinositide phospholipase C #=GS W4XRL3/339-503 DR ORG; Eukaryota; Metazoa; Echinodermata; Echinozoa; Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae; Strongylocentrotus; Strongylocentrotus purpuratus; #=GS D7ELR5/1072-1208 AC D7ELR5 #=GS D7ELR5/1072-1208 OS Tribolium castaneum #=GS D7ELR5/1072-1208 DE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma #=GS D7ELR5/1072-1208 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga; Cucujiformia; Tenebrionoidea; Tenebrionidae; Tribolium; Tribolium castaneum; #=GS A0A139W9F8/296-432 AC A0A139W9F8 #=GS A0A139W9F8/296-432 OS Tribolium castaneum #=GS A0A139W9F8/296-432 DE Phosphoinositide phospholipase C #=GS A0A139W9F8/296-432 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga; Cucujiformia; Tenebrionoidea; Tenebrionidae; Tribolium; Tribolium castaneum; #=GS B7P4X9/1069-1200 AC B7P4X9 #=GS B7P4X9/1069-1200 OS Ixodes scapularis #=GS B7P4X9/1069-1200 DE Phosphoinositide phospholipase C #=GS B7P4X9/1069-1200 DR ORG; Eukaryota; Metazoa; Arthropoda; Chelicerata; Arachnida; Acari; Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes; Ixodes scapularis; #=GS H3G127/1070-1226 AC H3G127 #=GS H3G127/1070-1226 OS Pristionchus pacificus #=GS H3G127/1070-1226 DE Phosphoinositide phospholipase C #=GS H3G127/1070-1226 DR ORG; Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Diplogasteromorpha; Diplogasteroidea; Neodiplogasteridae; Pristionchus; Pristionchus pacificus; #=GS G0PIK1/1107-1260 AC G0PIK1 #=GS G0PIK1/1107-1260 OS Caenorhabditis brenneri #=GS G0PIK1/1107-1260 DE Phosphoinositide phospholipase C #=GS G0PIK1/1107-1260 DR ORG; Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis; Caenorhabditis brenneri; #=GS A8XTZ1/1057-1213 AC A8XTZ1 #=GS A8XTZ1/1057-1213 OS Caenorhabditis briggsae #=GS A8XTZ1/1057-1213 DE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma #=GS A8XTZ1/1057-1213 DR ORG; Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis; Caenorhabditis briggsae; #=GS A0A2G5UVM8/718-871 AC A0A2G5UVM8 #=GS A0A2G5UVM8/718-871 OS Caenorhabditis nigoni #=GS A0A2G5UVM8/718-871 DE Phosphoinositide phospholipase C #=GS A0A2G5UVM8/718-871 DR ORG; Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis; Caenorhabditis nigoni; #=GS A0A1I7TAD1/1108-1261 AC A0A1I7TAD1 #=GS A0A1I7TAD1/1108-1261 OS Caenorhabditis tropicalis #=GS A0A1I7TAD1/1108-1261 DE Phosphoinositide phospholipase C #=GS A0A1I7TAD1/1108-1261 DR ORG; Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis; Caenorhabditis tropicalis; #=GS W5JCJ5/1120-1255 AC W5JCJ5 #=GS W5JCJ5/1120-1255 OS Anopheles darlingi #=GS W5JCJ5/1120-1255 DE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma #=GS W5JCJ5/1120-1255 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Nyssorhynchus; darlingi group; Anopheles darlingi; #=GS A0A182M1X0/1108-1243 AC A0A182M1X0 #=GS A0A182M1X0/1108-1243 OS Anopheles culicifacies #=GS A0A182M1X0/1108-1243 DE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma #=GS A0A182M1X0/1108-1243 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles culicifacies; #=GS A0A182HWB9/1069-1204 AC A0A182HWB9 #=GS A0A182HWB9/1069-1204 OS Anopheles arabiensis #=GS A0A182HWB9/1069-1204 DE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma #=GS A0A182HWB9/1069-1204 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles arabiensis; #=GS A0A182YB20/1096-1231 AC A0A182YB20 #=GS A0A182YB20/1096-1231 OS Anopheles stephensi #=GS A0A182YB20/1096-1231 DE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma #=GS A0A182YB20/1096-1231 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles stephensi; #=GS A0A182U1Z9/559-694 AC A0A182U1Z9 #=GS A0A182U1Z9/559-694 OS Anopheles melas #=GS A0A182U1Z9/559-694 DE Phosphoinositide phospholipase C #=GS A0A182U1Z9/559-694 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles melas; #=GS B5DNH4/1116-1250 AC B5DNH4 #=GS B5DNH4/1116-1250 OS Drosophila pseudoobscura pseudoobscura #=GS B5DNH4/1116-1250 DE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma #=GS B5DNH4/1116-1250 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; obscura group; pseudoobscura subgroup; Drosophila pseudoobscura; Drosophila pseudoobscura pseudoobscura; #=GS A0A3B0K862/1129-1263 AC A0A3B0K862 #=GS A0A3B0K862/1129-1263 OS Drosophila guanche #=GS A0A3B0K862/1129-1263 DE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma #=GS A0A3B0K862/1129-1263 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; obscura group; obscura subgroup; Drosophila guanche; #=GS B4PXS1/1099-1232 AC B4PXS1 #=GS B4PXS1/1099-1232 OS Drosophila yakuba #=GS B4PXS1/1099-1232 DE 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma #=GS B4PXS1/1099-1232 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila yakuba; #=GS B4IF63/675-806 AC B4IF63 #=GS B4IF63/675-806 OS Drosophila sechellia #=GS B4IF63/675-806 DE Phosphoinositide phospholipase C #=GS B4IF63/675-806 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila sechellia; #=GS A0A2A6B7C2/1065-1221 AC A0A2A6B7C2 #=GS A0A2A6B7C2/1065-1221 OS Pristionchus pacificus #=GS A0A2A6B7C2/1065-1221 DE Phosphoinositide phospholipase C #=GS A0A2A6B7C2/1065-1221 DR ORG; Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Diplogasteromorpha; Diplogasteroidea; Neodiplogasteridae; Pristionchus; Pristionchus pacificus; #=GS G0N3X3/1107-1260 AC G0N3X3 #=GS G0N3X3/1107-1260 OS Caenorhabditis brenneri #=GS G0N3X3/1107-1260 DE Phosphoinositide phospholipase C #=GS G0N3X3/1107-1260 DR ORG; Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis; Caenorhabditis brenneri; #=GF SQ 24 Q22070/1107-1259 ---TAYPIRLNVQVIGGRHLSRKDKNKGICSPFVEIEIIGMPCDT-KVFQTKTIASNGLNPIW-NQTFTFEIQCPEVALIRFHVEDGDFVGPKTDPFIGQAVFPVDSIRCGFRSVPLKNQYSEELELSSLLVDVQMCSREGTQLIRSSSHFLQASRLA-------------- Q9VXH3/1102-1235 LCDGLSEVKVSIRLIAARHLFR--GGKS-NNPQIVVELIGASFDTGVKYRTK-VNENGFNPVW-NESCEFNVRNPQFAILRFEVQDEDMFAETH--FIAQACYPLTCIRQGYRSVILRNKFSEELELSSLLINIKIANVTA------------------------------- Q7QHE3/1097-1232 -LVGVGEVIVNVRIIGGRNLCK--VSRNITSPLVEVEVLGASFDGGIKHRTRAIADNGLNPIW-NEICEFRIANPHFAMIRFEVQDEDMFGEPN--FIGQAVFPLGSIRTGYRSVVLRNKYSEELELATLLVHTSIRPLQTE------------------------------ A7SMY6/526-658 -TSGVEPLTLTLTVIGARHLVK--SGRGIASPFVEVEIVGAPYDC-HKFRTETKVDNGLNPLW-FSTFEVDILNSPLAYIRFVVYDEDMFGEPN--FIGHAIFPMGSLRTGYRSVPLKNSFSEDYEMSSLLAHIDVRSAK-------------------------------- W4XRL3/339-503 -LVDVDPIHLTITIIAARHLQK--TGRGIASPFVEVEILGSDYDSGNKYKTSTKADNGFNPVF-NEVCEFDVTNPDLAMLRFVIQDEDVFGEPN--FLGQATYPLKAIRTGYRSVQLKNGNSEELELATLLVHVERRVIGECD-DSDLYASIQMLRERTQELTAVVNTMDRP D7ELR5/1072-1208 -LVGVEPWIVTLRIIAARHLFR--PKKGTASPFVEVEVIGAPFDSGTKLSTKPVTDNGFNPRWMEEVIEFPVYNPYFALLRFVVQDEDVFGEPN--FIGQATYPVTCLRTGYRSVWLKNAYSEDLELASLLIHISIKRTSVS------------------------------ A0A139W9F8/296-432 -LVGVEPWIVTLRIIAARHLFR--PKKGTASPFVEVEVIGAPFDSGTKLSTKPVTDNGFNPRWMEEVIEFPVYNPYFALLRFVVQDEDVFGEPN--FIGQATYPVTCLRTGYRSVWLKNAYSEDLELASLLIHISIKRTSVS------------------------------ B7P4X9/1069-1200 SLKSVHPVTLAIKVIAARHLMK--SGRGIVSPFVEIEIVGADFDC-SKYKTGTIPDNGLNPIW-NEAFMFDVCNPSVALLRFVVQDEDMFGDPN--FLGQVTYPVSCLRTGNLS-PLKNEYSEELELASLLIHLEVYAT--------------------------------- H3G127/1070-1226 --GTSAPILMTIRVIAGRHLSRKDKNKGICSPFVEIEVLGLTCDE-KSVRTNTITSNGLNPFW-NESFTFPVHCPEIALLRFVAEDGDFVGPKTDPFIGQAVFPVDSIRPGYRSIPLKNQYSEELELSSLLVHVELTYLNGEK-DKSAHAIMQANRSMYY----------IS G0PIK1/1107-1260 ---TAYPIRLNVQVIGGRHLSRRDKNKGICSPFVEIEVIGMPCDT-KVYQTKTIASNGLNPIW-NQTFTFEIQCPEVALIRFHVEDGDFVGPKTDPFIGQAVFPVDSIRCGFRSVPLKNQYSEELELSALLVDVQMCSREGSQLIRSSSHFLQASRLA-------------P A8XTZ1/1057-1213 -VTTAYPIRLNVQVIGGRHLSRRDKNKGICSPFVEIEVIGMPCDT-KVYQTKTIASNGLNPIW-NQTFTFEIQCPEMALIRFHVEDGDFVGPKTDPFIGQAVFPVDSIRCGFRSVPLKNQYSEELELSALLVDVQMCSREGSQLIRSSSHFLQVSYFL------------KA A0A2G5UVM8/718-871 ---TAYPIRLNVQVIGGRHLSRRDKNKGICSPFVEIEVIGMPCDT-KVYQTKTIASNGLNPIW-NQTFTFEIQCPEMALIRFHVEDGDFVGPKTDPFIGQAVFPVDSIRCGFRSVPLKNQYSEELELSALLVDVQMCPREGNQLIRSSSHFLQASRLA-------------P A0A1I7TAD1/1108-1261 ---TAYPIRLNVQVIAGRHLSRRDKNKGICSPFVEIEVIGMPCDT-KVYQTKTIASNGLNPIW-NQTFTFEIQCPEVALIRFHVEDGDFVGPKTDPFIGQAVFPVDSIRCGFRSVPLKNQYSEELELSSLLVDVQMCSREGSQLIRSSSHFLQASRLA-------------P W5JCJ5/1120-1255 -LVGVGEVIVNVRIIGGRNLCK--VSRNVTSPLVEVEVLGAAFDAGVKHRTRAIADNGLNPIW-NEICEFRIANPHFAMLRFEVQDEDMFGEPN--FIGQAVFPLGAIRTGYRSVPLRNKYSEELELATLLVHTSIRPLQTE------------------------------ A0A182M1X0/1108-1243 -LVGVNEVIVNVRIIGGRNLCK--VSRNITSPLVEVEVLGASFDGGIKHRTRAIADNGLNPIW-NEICEFRIANPHFAMIRFEVQDEDMFGEPN--FIGQAVFPLGAIRTGYRSVVLRNKYSEELELATLLVHTSIRPLQTE------------------------------ A0A182HWB9/1069-1204 -LVGVGEVIVNVRIIGGRNLCK--VSRNITSPLVEVEVLGASFDGGIKHRTRAIADNGLNPIW-NEICEFRIANPHFAMIRFEVQDEDMFGEPN--FIGQAVFPLGSIRTGYRSVVLRNKYSEELELATLLVHTSIRPLQTE------------------------------ A0A182YB20/1096-1231 -LVGVNQMVVNVRIIGGRNLCK--VSRNITSPLVEVEVLGAPFDGGIKHRTRAIADNGLNPIW-NEICEFRIWNPHLAMIRFEVQDEDMFGEPN--FIGQAVFPVGAIRTGYRSIVLRNKYSEELELATLLVHTRIRSAQAE------------------------------ A0A182U1Z9/559-694 -LVGVGEVIVNVRIIGGRNLCK--VSRNITSPLVEVEVLGASFDGGIKHRTRAIADNGLNPIW-NEISEFRIANPHFAMIRFEVQDEDMFGEPN--FIGQAVFPLGSIRTGYRSVVLRNKYSEELELATLLVHTSIRPLQTE------------------------------ B5DNH4/1116-1250 LSDGLNEVRVSIRLIAARHLFR--GGKS-NNPQIVVEIMGASFDTGIKYRTK-VNENGFNPVW-NEACEFTVRNPQFAILRFEVQDEDMFAETH--FIAQACYPLTCVRQGYRSVILRNKFSEELELSSLLVNIKITNITST------------------------------ A0A3B0K862/1129-1263 LSDGLNEVRVIIRLIAARHLFR--GGKS-NNPQIVVEIIGASFDTGIKYRTK-VNENGFNPVW-NEACEFTVRNPQFAILRFEVQDEDMFAETH--FIAQACYPLTSVRQGYRSVILRNKFSEELELSSLLVNIKITNITST------------------------------ B4PXS1/1099-1232 LCDGLSEVKVSIRLIAARHLFR--GGKS-NNPQIVVEIVGASYDTGVKYRTK-VNENGFNPVW-NESCEFNVRNPQFAILRFEVQDEDMFAETH--FIAQACYPLTCIRQGYRSVILRNKFSEELELSSLLINIKVANATS------------------------------- B4IF63/675-806 --DGLSEVKVSIRLIAARHLFR--GGKS-NNPQIVVELVGASFDTGVKYRTK-VNENGFNPVW-NESCEFNVRNPQFAILRFEVQDEDMFAETH--FIAQACYPLTCIRQGYRSVILRNKFSEELELSSLLINIKIANVTA------------------------------- A0A2A6B7C2/1065-1221 --GTSAPILMTIRVIAGRHLSRKDKNKGICSPFVEIEVLGLTCDE-KSVRTNTITSNGLNPFW-NESFTFPVHCPEIALLRFVAEDGDFVGPKTDPFIGQAVFPVDSIRPGYRSIPLKNQYSEELELSSLLVHVELTYLNGEK-DKSAHAIMQANRSMYY----------IS G0N3X3/1107-1260 ---TAYPIRLNVQVIGGRHLSRRDKNKGICSPFVEIEVIGMPCDT-KVYQTKTIASNGLNPIW-NQTFTFEIQCPEVALIRFHVEDGDFVGPKTDPFIGQAVFPVDSIRCGFRSVPLKNQYSEELELSALLVDVQMCSREGSQLIRSSSHFLQASRLA-------------P #=GC scorecons 0225435536565696697937003475447947679659545942355595365599699580764558373584595699476969567545009878847964579497897497947998898659975545333332000010000010010000000000000000 #=GC scorecons_70 ___________*__*__***_*____*___**_*****_*___*______*_____*****_*_**___*_*__*__*_***_*_***__*_____*****_***__**_*****_***_*******__***________________________________________ #=GC scorecons_80 ______________*__*_*_*____*____*_*_**__*___*______*_____**_**_*_*____*____*__*__**_*_*_*________**_**_**____*_*****_*_*__******__**_________________________________________ #=GC scorecons_90 ______________*__*_*___________*____*__*___*______*_____**_**_*______*____*__*__**___*_*________**_**__*____*_*_**__*_*__******__**_________________________________________ //