The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1005: Beta-2-microglobulin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 P01887 (/IPI) P01887 (/IPI) P61769 (/IPI) P61769 (/IPI) P61769 (/IPI) P61769 (/IPI) P61769 (/IPI) P61769 (/IPI) Q04714 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
6 P61769 (/IPI) P61769 (/IPI) P61769 (/IPI) P61769 (/IPI) P61769 (/IPI) P61769 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
6 P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 P01887 (/ISO) P01887 (/ISO) Q04714 (/ISO)

There are 63 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
10 B5X5Y2 (/ISS) B5XE24 (/ISS) B9EM81 (/ISS) B9EQ88 (/ISS) C1C2P2 (/ISS) D7EZP8 (/ISS) E0R854 (/ISS) L7NL60 (/ISS) Q9DD37 (/ISS) Q9DG62 (/ISS)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
10 B5X5Y2 (/ISS) B5XE24 (/ISS) B9EM81 (/ISS) B9EQ88 (/ISS) C1C2P2 (/ISS) D7EZP8 (/ISS) E0R854 (/ISS) L7NL60 (/ISS) Q9DD37 (/ISS) Q9DG62 (/ISS)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
7 C1BFC6 (/IDA) C1BHK1 (/IDA) Q91202 (/IDA) Q91203 (/IDA) Q91204 (/IDA) Q91966 (/IDA) Q92004 (/IDA)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
7 C1BFC6 (/IDA) C1BHK1 (/IDA) Q91202 (/IDA) Q91203 (/IDA) Q91204 (/IDA) Q91966 (/IDA) Q92004 (/IDA)
Retina homeostasis GO:0001895
A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function.
6 P61769 (/HEP) P61769 (/HEP) P61769 (/HEP) P61769 (/HEP) P61769 (/HEP) P61769 (/HEP)
Antigen processing and presentation of peptide antigen via MHC class I GO:0002474
The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Positive regulation of T cell cytokine production GO:0002726
Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.
6 P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
6 P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
6 P61769 (/ISS) P61769 (/ISS) P61769 (/ISS) P61769 (/ISS) P61769 (/ISS) P61769 (/ISS)
Antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885
The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.
6 P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI)
Positive regulation of protein binding GO:0032092
Any process that activates or increases the frequency, rate or extent of protein binding.
6 P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI)
Regulation of iron ion transport GO:0034756
Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
6 P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Positive regulation of receptor-mediated endocytosis GO:0048260
Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
6 P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
6 P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA)
Regulation of defense response to virus by virus GO:0050690
Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Negative regulation of neurogenesis GO:0050768
Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
6 P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA)
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
6 P61769 (/IMP) P61769 (/IMP) P61769 (/IMP) P61769 (/IMP) P61769 (/IMP) P61769 (/IMP)
Iron ion homeostasis GO:0055072
Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
6 P61769 (/IC) P61769 (/IC) P61769 (/IC) P61769 (/IC) P61769 (/IC) P61769 (/IC)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Cellular response to iron ion GO:0071281
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
6 P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI)
Cellular response to nicotine GO:0071316
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.
6 P61769 (/IMP) P61769 (/IMP) P61769 (/IMP) P61769 (/IMP) P61769 (/IMP) P61769 (/IMP)
Modulation of age-related behavioral decline GO:0090647
Any process that modulates the processes that arise as an organism progresses toward the end of its lifespan that results in a decline in behavioral activities such as locomotory behavior, and learning or memory.
6 P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA)
Negative regulation of receptor binding GO:1900121
Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor.
6 P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA)
Positive regulation of receptor binding GO:1900122
Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor.
6 P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI)
Positive regulation of ferrous iron binding GO:1904434
Any process that activates or increases the frequency, rate or extent of ferrous iron binding.
6 P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI)
Positive regulation of transferrin receptor binding GO:1904437
Any process that activates or increases the frequency, rate or extent of transferrin receptor binding.
6 P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI) P61769 (/IGI)
Amyloid fibril formation GO:1990000
The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins.
6 P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA)
Positive regulation of cellular senescence GO:2000774
Any process that activates or increases the frequency, rate or extent of cellular senescence.
6 P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA)
Negative regulation of forebrain neuron differentiation GO:2000978
Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation.
6 P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA)
Positive regulation of T cell mediated cytotoxicity GO:0001916
Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.
3 P01887 (/IMP) P01887 (/IMP) Q04714 (/IMP)
Response to molecule of bacterial origin GO:0002237
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.
3 P01887 (/IMP) P01887 (/IMP) Q04714 (/IMP)
Antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent GO:0002481
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
3 P01887 (/IMP) P01887 (/IMP) Q04714 (/IMP)
Positive regulation of T cell cytokine production GO:0002726
Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.
3 P01887 (/ISO) P01887 (/ISO) Q04714 (/ISO)
Iron ion transport GO:0006826
The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 P01887 (/IMP) P01887 (/IMP) Q04714 (/IMP)
Cellular defense response GO:0006968
A defense response that is mediated by cells.
3 P01887 (/TAS) P01887 (/TAS) Q04714 (/TAS)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
3 P01887 (/IGI) P01887 (/IGI) Q04714 (/IGI)
Antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885
The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.
3 P01887 (/ISO) P01887 (/ISO) Q04714 (/ISO)
Positive regulation of protein binding GO:0032092
Any process that activates or increases the frequency, rate or extent of protein binding.
3 P01887 (/ISO) P01887 (/ISO) Q04714 (/ISO)
T cell differentiation in thymus GO:0033077
The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.
3 P01887 (/IGI) P01887 (/IGI) Q04714 (/IGI)
Regulation of iron ion transport GO:0034756
Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 P01887 (/ISO) P01887 (/ISO) Q04714 (/ISO)
Protein refolding GO:0042026
The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.
3 P01887 (/IDA) P01887 (/IDA) Q04714 (/IDA)
Regulation of erythrocyte differentiation GO:0045646
Any process that modulates the frequency, rate or extent of erythrocyte differentiation.
3 P01887 (/IMP) P01887 (/IMP) Q04714 (/IMP)
Positive regulation of receptor-mediated endocytosis GO:0048260
Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
3 P01887 (/ISO) P01887 (/ISO) Q04714 (/ISO)
Iron ion homeostasis GO:0055072
Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
3 P01887 (/IMP) P01887 (/IMP) Q04714 (/IMP)
Cellular response to iron ion GO:0071281
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
3 P01887 (/ISO) P01887 (/ISO) Q04714 (/ISO)
Cellular response to iron(III) ion GO:0071283
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus.
3 P01887 (/IMP) P01887 (/IMP) Q04714 (/IMP)
Negative regulation of receptor binding GO:1900121
Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor.
3 P01887 (/ISO) P01887 (/ISO) Q04714 (/ISO)
Positive regulation of receptor binding GO:1900122
Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor.
3 P01887 (/ISO) P01887 (/ISO) Q04714 (/ISO)
Positive regulation of ferrous iron binding GO:1904434
Any process that activates or increases the frequency, rate or extent of ferrous iron binding.
3 P01887 (/ISO) P01887 (/ISO) Q04714 (/ISO)
Positive regulation of transferrin receptor binding GO:1904437
Any process that activates or increases the frequency, rate or extent of transferrin receptor binding.
3 P01887 (/ISO) P01887 (/ISO) Q04714 (/ISO)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
2 P01887 (/IMP) P01887 (/IMP)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
2 P01887 (/IMP) P01887 (/IMP)
Negative regulation of neurogenesis GO:0050768
Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
2 P01887 (/IMP) P01887 (/IMP)
Modulation of age-related behavioral decline GO:0090647
Any process that modulates the processes that arise as an organism progresses toward the end of its lifespan that results in a decline in behavioral activities such as locomotory behavior, and learning or memory.
2 P01887 (/IMP) P01887 (/IMP)
Negative regulation of forebrain neuron differentiation GO:2000978
Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation.
2 P01887 (/IMP) P01887 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P07151 (/IEP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 P07151 (/IEP)

There are 31 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
10 B5X5Y2 (/ISS) B5XE24 (/ISS) B9EM81 (/ISS) B9EQ88 (/ISS) C1C2P2 (/ISS) D7EZP8 (/ISS) E0R854 (/ISS) L7NL60 (/ISS) Q9DD37 (/ISS) Q9DG62 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
8 P01887 (/HDA) P01887 (/HDA) P61769 (/HDA) P61769 (/HDA) P61769 (/HDA) P61769 (/HDA) P61769 (/HDA) P61769 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
8 C1BFC6 (/IDA) C1BHK1 (/IDA) P07151 (/IDA) Q91202 (/IDA) Q91203 (/IDA) Q91204 (/IDA) Q91966 (/IDA) Q92004 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
8 F5H6I0 (/IDA) F5H6I0 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 F5H6I0 (/IDA) F5H6I0 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
8 F5H6I0 (/IDA) F5H6I0 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA)
Phagocytic vesicle membrane GO:0030670
The lipid bilayer surrounding a phagocytic vesicle.
8 P01887 (/TAS) P01887 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
6 P61769 (/HDA) P61769 (/HDA) P61769 (/HDA) P61769 (/HDA) P61769 (/HDA) P61769 (/HDA)
ER to Golgi transport vesicle membrane GO:0012507
The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
6 P61769 (/HDA) P61769 (/HDA) P61769 (/HDA) P61769 (/HDA) P61769 (/HDA) P61769 (/HDA)
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Early endosome lumen GO:0031905
The volume enclosed by the membrane of an early endosome.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Specific granule lumen GO:0035580
The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
MHC class I protein complex GO:0042612
A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.
6 P61769 (/NAS) P61769 (/NAS) P61769 (/NAS) P61769 (/NAS) P61769 (/NAS) P61769 (/NAS)
MHC class I protein complex GO:0042612
A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
MHC class I peptide loading complex GO:0042824
A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.
6 P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA)
Recycling endosome membrane GO:0055038
The lipid bilayer surrounding a recycling endosome.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
6 P61769 (/HDA) P61769 (/HDA) P61769 (/HDA) P61769 (/HDA) P61769 (/HDA) P61769 (/HDA)
Tertiary granule lumen GO:1904724
Any membrane-enclosed lumen that is part of a tertiary granule.
6 P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS) P61769 (/TAS)
HFE-transferrin receptor complex GO:1990712
A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.
6 P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA) P61769 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 P01887 (/ISO) P01887 (/ISO) Q04714 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
3 P01887 (/ISO) P01887 (/ISO) Q04714 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P01887 (/ISO) P01887 (/ISO) Q04714 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P01887 (/ISO) P01887 (/ISO) Q04714 (/ISO)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
3 P01887 (/IDA) P01887 (/IDA) Q04714 (/IDA)
MHC class I peptide loading complex GO:0042824
A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.
3 P01887 (/ISO) P01887 (/ISO) Q04714 (/ISO)
HFE-transferrin receptor complex GO:1990712
A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.
3 P01887 (/ISO) P01887 (/ISO) Q04714 (/ISO)