The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Trypsin-like serine proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 14: Complement factor D

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Granzyme A. [EC: 3.4.21.78]
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- >> -Phe-|- Xaa- in small molecule substrates.
  • From cytotoxic T lymphocyte granules.
  • The human enzyme does not cleave Phe-|-Xaa.
  • Belongs to peptidase family S1.
9 L8J1B0 L8J1B0 P11032 P11032 P12544 Q3U0N0 Q3U0N0 Q7YRZ7 Q7YRZ7
Chymase. [EC: 3.4.21.39]
Preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa.
  • In mast cell granules.
  • Belongs to peptidase family S1.
7 P09650 P21842 P21844 P23946 P50339 P52195 P56435
Granzyme B. [EC: 3.4.21.79]
Preferential cleavage: -Asp-|-Xaa- >> -Asn-|-Xaa- > -Met-|-Xaa-, -Ser-|-Xaa-.
  • From cytotoxic T lymphocyte granules.
  • Belongs to peptidase family S1.
6 P04187 P04187 P10144 P18291 Q3TZH4 Q3TZH4
Complement factor D. [EC: 3.4.21.46]
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
  • A component of the alternative pathway of complement activation.
  • This reaction is analogous to the activation of complement component C2 by activated complement subcomponent C1s.
  • Belongs to peptidase family S1.
6 P00746 P03953 P03953 P32038 Q3UP47 Q3UP47
Cathepsin G. [EC: 3.4.21.20]
Specificity similar to chymotrypsin C.
  • From azurophil granules of polymorphonuclear leukocytes.
  • Belongs to peptidase family S1.
5 P08311 P28293 P28293 Q059V7 Q059V7