The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Hepatitis C NS5A, domain 1B

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Hepatitis C NS5A, domain 1B

The non-structural protein NS5A is an active hepatitis C virus (HCV) replicase component, a pivotal regulator of replication, and a modulator of several cellular processes which range from innate immunity to dysregulated cell growth. NS5A is organized into three domains, labelled I, II and III. Domain I contains a zinc-binding motif and an amphipathic N-terminal helix which promotes membrane association. Mutations disrupting either the membrane anchor or zinc binding are lethal for RNA replication PMID:19244328,PMID:24639329.

Structural domains comprising this superfamily share the structure of domain 1A of the hepatitis C virus NS5A protein. This domain is involved in zinc binding and it is thought to be key for fold maintenance and is essential for replicase function PMID:15902263.

GO Diversity

Unique GO annotations
35 Unique GO terms

EC Diversity

Unique EC annotations
4 Unique EC terms

Species Diversity

Unique species annotations
95 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 10
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 4
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 3
Unique EC: 4
Unique GO: 35
Unique Species: 95