The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Spindle assembly abnormal protein 6, N-terminal domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Spindle assembly abnormal protein 6, N-terminal domain

Structural domains comprising this superfamily share the structure of the N-terminal domain of the highly conserved centriolar protein SAS-6 (spindle assembly abnormal protein 6). SAS-6 is the center of the cartwheel assembly that scaffolds centrioles early in their biogenesis. Structural studies have shown that SAS-6 self-associates in vitro into assemblies that resemble cartwheel centers through the formation of a parallel coiled-coil dimer PMID:21273447 This homodimers interact via virtue of their N-terminal domains to form oligomers. This oligomerization process is essential for centriole formation in C. elegans and human cells PMID:21273447.

GO Diversity

Unique GO annotations
22 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
576 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 44
Domain clusters (>95% seq id): 7
Domain clusters (>35% seq id): 6
Unique PDBs: 13
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 5
Unique EC:
Unique GO: 22
Unique Species: 576