The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

RIG-I-like receptor, C-terminal regulatory domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: RIG-I-like receptor, C-terminal regulatory domain

The RIG-I like receptors (RLRs) are cytosolic pattern recognition receptors of viral RNA that mediate the innate anti-viral immune responses. Structural domains comprising this superfamily share the structure of the C-terminal domain of RIG-I (Retinoic acid Inducible Gene - I), a RLR that recognizes pathogen-associated molecular pattern (PAMP) motifs to differentiate between viral and cellular RNAs. Its C-terminal regulatory domain (CTR) binds viral RNA in a 5'-triphosphate-dependent manner and activates the RIG-I ATPase by RNA-dependent dimerization. To facilitate the detection of a broad range of non-self RNA targets, each RLR contains a similar but divergent CTR domain that mediates RLR-specific interactions between bound nucleic acids or neighbouring patterns PMID:20961956 PMID:18243112.

GO Diversity

Unique GO annotations
69 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
283 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 69
Domain clusters (>95% seq id): 5
Domain clusters (>35% seq id): 3
Unique PDBs: 25
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 6
Unique EC: 1
Unique GO: 69
Unique Species: 283