The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Telomere length regulation protein 2, C-terminal domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Tel2 C-terminal domain

Tel2 has long been an enigmatic gene, implicated in a myriad of apparently unrelated biological processes in worms, budding yeast, and fission yeast. An explanation for these varied phenotypes emerged from the finding that mammalian Tel2 is required for the stability of all phosphatidylinositol 3-kinase-related protein kinases (PIKKs). Tel2 consists of HEAT-like helical repeats that assemble into two separate alpha-solenoids PMID:20801936. This entry represents the C-terminal solenoid (C-terminal domain) which is made up of 11 helices.


GO Diversity

Unique GO annotations
38 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1301 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 4
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 30
Unique EC:
Unique GO: 38
Unique Species: 1301