The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
alix/aip1 like domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: programmed cell death 6-interacting protein-like i...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q80Y09 (/IPI) Q8WUM4 (/IPI) Q9VB05 (/IPI) Q9WU78 (/IPI)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
1 Q9QZA2 (/IDA)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
1 Q9WU78 (/ISO)
Proteinase activated receptor binding GO:0031871
Interacting selectively and non-covalently with a proteinase activated receptor.
1 Q8WUM4 (/IPI)
Proteinase activated receptor binding GO:0031871
Interacting selectively and non-covalently with a proteinase activated receptor.
1 Q9WU78 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q8WUM4 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9WU78 (/ISO)
Protein dimerization activity GO:0046983
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
1 Q9WU78 (/IPI)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
1 Q8WUM4 (/IPI)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
1 Q9WU78 (/ISO)

There are 44 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
4 Q9QZA2 (/ISS) Q9W6C5 (/ISS) Q9W6C5 (/ISS) Q9WU78 (/ISS)
Actomyosin contractile ring assembly GO:0000915
The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis.
2 Q8WUM4 (/ISS) Q9QZA2 (/ISS)
Maintenance of epithelial cell apical/basal polarity GO:0045199
The maintenance of the apicobasal polarity of an epithelial cell.
2 Q8WUM4 (/ISS) Q9QZA2 (/ISS)
Bicellular tight junction assembly GO:0070830
The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet.
2 Q8WUM4 (/ISS) Q9QZA2 (/ISS)
Regulation of membrane permeability GO:0090559
Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane.
2 Q8WUM4 (/ISS) Q9QZA2 (/ISS)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 Q8WUM4 (/IDA)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 Q9VB05 (/IMP)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 Q9WU78 (/ISO)
Actomyosin contractile ring assembly GO:0000915
The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis.
1 Q9WU78 (/IMP)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 Q9WU78 (/TAS)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
1 Q8T7K0 (/IMP)
Anatomical structure morphogenesis GO:0009653
The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
1 Q8T7K0 (/IMP)
Regulation of centrosome duplication GO:0010824
Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
1 Q8WUM4 (/IMP)
Regulation of centrosome duplication GO:0010824
Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
1 Q9WU78 (/ISO)
Viral life cycle GO:0019058
A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome.
1 Q8WUM4 (/TAS)
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
1 Q9VB05 (/IMP)
Negative regulation of sorocarp stalk cell differentiation GO:0031286
Any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.
1 Q8T7K0 (/IMP)
Multivesicular body assembly GO:0036258
The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
1 Q8WUM4 (/NAS)
Viral budding via host ESCRT complex GO:0039702
Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process.
1 Q8WUM4 (/IGI)
Viral budding via host ESCRT complex GO:0039702
Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process.
1 Q9WU78 (/ISO)
Viral budding via host ESCRT complex GO:0039702
Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process.
1 Q8WUM4 (/NAS)
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162
The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.
1 Q9VB05 (/ISS)
Maintenance of epithelial cell apical/basal polarity GO:0045199
The maintenance of the apicobasal polarity of an epithelial cell.
1 Q9WU78 (/IMP)
Positive regulation of sporulation resulting in formation of a cellular spore GO:0045881
Any process that activates or increases the frequency, rate or extent of sporulation.
1 Q8T7K0 (/IMP)
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 Q9VB05 (/IDA)
Viral budding GO:0046755
A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space.
1 Q8WUM4 (/IDA)
Viral budding GO:0046755
A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space.
1 Q9WU78 (/ISO)
Female germ-line stem cell asymmetric division GO:0048132
The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes.
1 Q9VB05 (/IMP)
Male germ-line stem cell asymmetric division GO:0048133
The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes.
1 Q9VB05 (/IMP)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 Q8WUM4 (/IDA)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 Q9WU78 (/ISO)
Midbody abscission GO:0061952
The process by which the midbody, the cytoplasmic bridge that connects the two prospective daughter cells, is severed at the end of mitotic cytokinesis, resulting in two separate daughter cells.
1 Q8WUM4 (/IMP)
Midbody abscission GO:0061952
The process by which the midbody, the cytoplasmic bridge that connects the two prospective daughter cells, is severed at the end of mitotic cytokinesis, resulting in two separate daughter cells.
1 Q9WU78 (/ISO)
Bicellular tight junction assembly GO:0070830
The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet.
1 Q9WU78 (/IMP)
Regulation of membrane permeability GO:0090559
Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane.
1 Q9WU78 (/IMP)
Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway GO:0090611
The chemical reactions and pathways resulting in the breakdown of a protein or peptide, via the multivesicular body (MVB) sorting pathway; proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. This process is independent of ubiquitination.
1 Q8WUM4 (/IMP)
Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway GO:0090611
The chemical reactions and pathways resulting in the breakdown of a protein or peptide, via the multivesicular body (MVB) sorting pathway; proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. This process is independent of ubiquitination.
1 Q9WU78 (/ISO)
Positive regulation of exosomal secretion GO:1903543
Any process that activates or increases the frequency, rate or extent of exosomal secretion.
1 Q8WUM4 (/IMP)
Positive regulation of exosomal secretion GO:1903543
Any process that activates or increases the frequency, rate or extent of exosomal secretion.
1 Q9WU78 (/ISO)
Regulation of extracellular exosome assembly GO:1903551
Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly.
1 Q8WUM4 (/IMP)
Regulation of extracellular exosome assembly GO:1903551
Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly.
1 Q9WU78 (/ISO)
Positive regulation of extracellular exosome assembly GO:1903553
Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly.
1 Q8WUM4 (/IMP)
Positive regulation of extracellular exosome assembly GO:1903553
Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly.
1 Q9WU78 (/ISO)
Exosomal secretion GO:1990182
The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.
1 Q9VB05 (/IMP)

There are 28 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Flemming body GO:0090543
A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge.
4 Q9QZA2 (/ISS) Q9W6C5 (/ISS) Q9W6C5 (/ISS) Q9WU78 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 Q9QZA2 (/ISS) Q9W6C5 (/ISS) Q9W6C5 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q8T7K0 (/IDA) Q9QZA2 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q8WUM4 (/IDA) Q9WU78 (/IDA)
Actomyosin GO:0042641
Any complex of actin, myosin, and accessory proteins.
2 Q8WUM4 (/ISS) Q9QZA2 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q8WUM4 (/IDA) Q9WU78 (/IDA)
Immunological synapse GO:0001772
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
1 Q8WUM4 (/IDA)
Immunological synapse GO:0001772
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
1 Q9WU78 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9WU78 (/ISO)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 Q8T7K0 (/IDA)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 Q9VB05 (/ISS)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 Q9VB05 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9WU78 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8WUM4 (/TAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 Q8WUM4 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q8WUM4 (/HDA)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
1 Q9VB05 (/IDA)
Actomyosin GO:0042641
Any complex of actin, myosin, and accessory proteins.
1 Q9WU78 (/IDA)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
1 Q9WU78 (/HDA)
Intercellular bridge GO:0045171
A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.
1 Q9VB05 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q8WUM4 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q9WU78 (/ISO)
Contractile ring GO:0070938
A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles.
1 Q9VB05 (/IDA)
Endoplasmic reticulum exit site GO:0070971
An endoplasmic reticulum part at which COPII-coated vesicles are produced.
1 Q8WUM4 (/IMP)
Endoplasmic reticulum exit site GO:0070971
An endoplasmic reticulum part at which COPII-coated vesicles are produced.
1 Q9WU78 (/ISO)
Flemming body GO:0090543
A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge.
1 Q8WUM4 (/IDA)
Flemming body GO:0090543
A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge.
1 Q9WU78 (/ISO)
Extracellular vesicle GO:1903561
Any vesicle that is part of the extracellular region.
1 Q8WUM4 (/HDA)