The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

TAFH/NHR1 domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: TAFH/NHR1 domain

The general transcription factor TFIID is key in the regulation of gene transcription by RNA polymerase II and is composed of the TATA-binding protein (TBP) and at least 14 additional TBP-associated factors (TAFs). It mediates activities such as core promoter recognition and chromatin modification, necessary for the regulation of transcription. Individual TAFs are important for mediating distinct activator-specific transcriptional regulation in vivo PMID:17483474.

Structural domains comprising this superfamily share the structure of the TAF homology (TAFH), or Nervy homology region 1 (NHR1), domain which is present in eukaryotic proteins of the MTG/ETO family and whereof the core residues occur in TAF proteins. The TAFH/NHR1 domain can be involved in protein-protein interactions, e.g in MTG8/ETO with HSP90 and Gfi-1 PMID:10076566.

GO Diversity

Unique GO annotations
58 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
410 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 4
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 2
Unique PDBs: 4
Structural Clusters (5A): 2
Structural Clusters (9A): 1
FunFam Clusters: 14
Unique EC:
Unique GO: 58
Unique Species: 410