The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
STAT transcription factor, all-alpha domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Signal transducer and activator of transcription

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 47 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
31 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(21 more)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
31 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(21 more)
Protein dimerization activity GO:0046983
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
31 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(21 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
26 P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI)
(16 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
26 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(16 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
23 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(13 more)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
23 P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI)
(13 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
23 P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI)
(13 more)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
22 P40763 (/ISA) P40763 (/ISA) P40763 (/ISA) P40763 (/ISA) P40763 (/ISA) P40763 (/ISA) P40763 (/ISA) P40763 (/ISA) P40763 (/ISA) P40763 (/ISA)
(12 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
22 P40763 (/ISM) P40763 (/ISM) P40763 (/ISM) P40763 (/ISM) P40763 (/ISM) P40763 (/ISM) P40763 (/ISM) P40763 (/ISM) P40763 (/ISM) P40763 (/ISM)
(12 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
22 P40763 (/NAS) P40763 (/NAS) P40763 (/NAS) P40763 (/NAS) P40763 (/NAS) P40763 (/NAS) P40763 (/NAS) P40763 (/NAS) P40763 (/NAS) P40763 (/NAS)
(12 more)
RNA polymerase II repressing transcription factor binding GO:0001103
Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription.
22 P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI)
(12 more)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
22 P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP)
(12 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Nuclear receptor activity GO:0004879
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
22 P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI) P40763 (/IPI)
(12 more)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
5 P42227 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q19S50 (/ISS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
4 P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q19S50 (/ISS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
4 P42227 (/ISS) Q32LP6 (/ISS) Q6DV79 (/ISS) Q6DV79 (/ISS)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
4 P42227 (/IDA) P52631 (/IDA) Q9PVX8 (/IDA) Q9PVX8 (/IDA)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
3 P42227 (/IPI) Q9PVX8 (/IPI) Q9PVX8 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 P42227 (/IDA) P52631 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 P42227 (/ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P42227 (/IDA)
RNA polymerase II repressing transcription factor binding GO:0001103
Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription.
1 P42227 (/ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P42227 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P42227 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 P42227 (/IMP)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 P42227 (/ISO)
Nuclear receptor activity GO:0004879
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
1 P42227 (/ISO)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 P42227 (/ISO)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
1 P42227 (/ISO)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
1 P42227 (/ISO)
CCR5 chemokine receptor binding GO:0031730
Interacting selectively and non-covalently with a CCR5 chemokine receptor.
1 P52631 (/IPI)
CCR5 chemokine receptor binding GO:0031730
Interacting selectively and non-covalently with a CCR5 chemokine receptor.
1 P42227 (/ISO)
Glucocorticoid receptor binding GO:0035259
Interacting selectively and non-covalently with a glucocorticoid receptor.
1 P52631 (/IPI)
Glucocorticoid receptor binding GO:0035259
Interacting selectively and non-covalently with a glucocorticoid receptor.
1 P42227 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P42227 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P42227 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 P42227 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q7ZXK3 (/ISS)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 P42227 (/ISO)
Protein dimerization activity GO:0046983
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
1 P42227 (/IPI)

There are 189 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
32 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(22 more)
Temperature homeostasis GO:0001659
A homeostatic process in which an organism modulates its internal body temperature.
31 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(21 more)
Eye photoreceptor cell differentiation GO:0001754
The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.
31 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(21 more)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
31 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(21 more)
Sexual reproduction GO:0019953
A reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny.
31 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(21 more)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
31 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(21 more)
Eating behavior GO:0042755
The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.
31 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(21 more)
Growth hormone receptor signaling pathway via JAK-STAT GO:0060397
The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
30 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(20 more)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
26 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(16 more)
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
26 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(16 more)
Positive regulation of Notch signaling pathway GO:0045747
Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
26 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(16 more)
Astrocyte differentiation GO:0048708
The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
26 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(16 more)
Radial glial cell differentiation GO:0060019
The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
26 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(16 more)
Regulation of feeding behavior GO:0060259
Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.
26 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(16 more)
T-helper 17 cell lineage commitment GO:0072540
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
26 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(16 more)
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
26 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(16 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
25 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(15 more)
Receptor signaling pathway via JAK-STAT GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
24 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(14 more)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
23 P40763 (/NAS) P40763 (/NAS) P40763 (/NAS) P40763 (/NAS) P40763 (/NAS) P40763 (/NAS) P40763 (/NAS) P40763 (/NAS) P40763 (/NAS) P40763 (/NAS)
(13 more)
Leptin-mediated signaling pathway GO:0033210
A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
23 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(13 more)
Response to leptin GO:0044321
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].
23 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(13 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
23 P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP)
(13 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
23 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(13 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
23 P40763 (/IGI) P40763 (/IGI) P40763 (/IGI) P40763 (/IGI) P40763 (/IGI) P40763 (/IGI) P40763 (/IGI) P40763 (/IGI) P40763 (/IGI) P40763 (/IGI)
(13 more)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
23 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(13 more)
Growth hormone receptor signaling pathway via JAK-STAT GO:0060397
The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
23 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(13 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
22 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(12 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
22 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(12 more)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
22 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(12 more)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
22 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(12 more)
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
22 P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP)
(12 more)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
22 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(12 more)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
22 P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP)
(12 more)
Intracellular receptor signaling pathway GO:0030522
Any series of molecular signals initiated by a ligand binding to an receptor located within a cell.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Cellular response to hormone stimulus GO:0032870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Somatic stem cell population maintenance GO:0035019
Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.
22 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(12 more)
MiRNA mediated inhibition of translation GO:0035278
The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Interleukin-15-mediated signaling pathway GO:0035723
A series of molecular signals initiated by the binding of interleukin-15 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
22 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(12 more)
Interleukin-7-mediated signaling pathway GO:0038111
A series of molecular signals initiated by the binding of interleukin-7 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
22 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(12 more)
Interleukin-9-mediated signaling pathway GO:0038113
A series of molecular signals initiated by the binding of interleukin-9 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
22 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(12 more)
Interleukin-21-mediated signaling pathway GO:0038114
A series of molecular signals initiated by the binding of interleukin-21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
22 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(12 more)
Interleukin-23-mediated signaling pathway GO:0038155
A series of molecular signals initiated by the binding of interleukin-23 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
22 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(12 more)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
22 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(12 more)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
22 P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP)
(12 more)
Cellular response to leptin stimulus GO:0044320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Positive regulation of interleukin-6 biosynthetic process GO:0045410
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.
22 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(12 more)
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
22 P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP)
(12 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
22 P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP)
(12 more)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
22 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(12 more)
Growth hormone receptor signaling pathway GO:0060396
The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
22 P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP)
(12 more)
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
22 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(12 more)
Interleukin-27-mediated signaling pathway GO:0070106
A series of molecular signals initiated by the binding of interleukin-27 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
22 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(12 more)
Interleukin-35-mediated signaling pathway GO:0070757
A series of molecular signals initiated by the binding of interleukin-35 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
22 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(12 more)
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
22 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(12 more)
Positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895
Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription mediated by RNA polymerase II.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Positive regulation of metalloendopeptidase activity GO:1904685
Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity.
22 P40763 (/IGI) P40763 (/IGI) P40763 (/IGI) P40763 (/IGI) P40763 (/IGI) P40763 (/IGI) P40763 (/IGI) P40763 (/IGI) P40763 (/IGI) P40763 (/IGI)
(12 more)
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Phospholipid homeostasis GO:0055091
Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell.
10 Q6GU23 (/IMP) Q6GU23 (/IMP) Q6GU23 (/IMP) Q6GU23 (/IMP) Q6GU23 (/IMP) Q6GU23 (/IMP) Q6GU23 (/IMP) Q6GU23 (/IMP) Q6GU23 (/IMP) Q6GU23 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
7 P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q19S50 (/ISS) Q32LP6 (/ISS) Q6DV79 (/ISS) Q6DV79 (/ISS)
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Establishment of planar polarity GO:0001736
Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Epithelial to mesenchymal transition GO:0001837
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Axis elongation GO:0003401
The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure.
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Receptor signaling pathway via JAK-STAT GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Regulation of cell size GO:0008361
Any process that modulates the size of a cell.
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Establishment of cell polarity GO:0030010
The specification and formation of anisotropic intracellular organization or cell growth patterns.
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Regeneration GO:0031099
The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass).
6 A0A0R4IGF2 (/IGI) A0A1S6L757 (/IGI) C0SPC7 (/IGI) O93599 (/IGI) Q6NV46 (/IGI) Q7ZTS5 (/IGI)
Posterior lateral line neuromast hair cell development GO:0035677
The process whose specific outcome is the progression of a posterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate.
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Cell migration involved in gastrulation GO:0042074
The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Retina morphogenesis in camera-type eye GO:0060042
The process in which the anatomical structure of the retina is generated and organized.
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Inner ear receptor cell development GO:0060119
The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Positive regulation of glial cell proliferation GO:0060252
Any process that activates or increases the rate or extent of glial cell proliferation.
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Cardiac muscle tissue regeneration GO:0061026
The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Hepatocyte differentiation GO:0070365
The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver.
6 A0A0R4IGF2 (/IMP) A0A1S6L757 (/IMP) C0SPC7 (/IMP) O93599 (/IMP) Q6NV46 (/IMP) Q7ZTS5 (/IMP)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
5 P42227 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q19S50 (/ISS)
Leptin-mediated signaling pathway GO:0033210
A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
5 P42227 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q19S50 (/ISS)
Cellular response to leptin stimulus GO:0044320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.
5 P42227 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q19S50 (/ISS)
Response to leptin GO:0044321
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].
5 P42227 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q19S50 (/ISS)
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
5 P42227 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q19S50 (/ISS)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
5 P42227 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q19S50 (/ISS)
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
5 P42227 (/ISS) P52631 (/ISS) P61635 (/ISS) Q19S50 (/ISS) Q19S50 (/ISS)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
3 Q32LP6 (/ISS) Q6DV79 (/ISS) Q6DV79 (/ISS)
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
3 Q32LP6 (/ISS) Q6DV79 (/ISS) Q6DV79 (/ISS)
Mesoderm formation GO:0001707
The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
2 Q9PVX8 (/IMP) Q9PVX8 (/IMP)
Neural crest cell differentiation GO:0014033
The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.
2 Q9PVX8 (/IMP) Q9PVX8 (/IMP)
Temperature homeostasis GO:0001659
A homeostatic process in which an organism modulates its internal body temperature.
1 P42227 (/IMP)
Mesoderm formation GO:0001707
The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
1 Q7ZXK3 (/ISS)
Eye photoreceptor cell differentiation GO:0001754
The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.
1 P42227 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P42227 (/ISO)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P42227 (/NAS)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
1 P42227 (/IDA)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
1 P42227 (/ISO)
Acute-phase response GO:0006953
An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.
1 P52631 (/IEP)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 P42227 (/IMP)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 P52631 (/IEP)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 P42227 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P52631 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P42227 (/ISO)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P42227 (/IGI)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 P52631 (/IEP)
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 P42227 (/ISO)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P42227 (/IGI)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P42227 (/ISO)
Negative regulation of hydrogen peroxide biosynthetic process GO:0010730
Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
1 P52631 (/IMP)
Negative regulation of hydrogen peroxide biosynthetic process GO:0010730
Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.
1 P42227 (/ISO)
Neural crest cell differentiation GO:0014033
The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.
1 Q7ZXK3 (/ISS)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P52631 (/IEP)
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
1 P42227 (/IDA)
Stem cell population maintenance GO:0019827
The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.
1 P42227 (/IMP)
Sexual reproduction GO:0019953
A reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny.
1 P42227 (/IMP)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 P42227 (/ISO)
Intracellular receptor signaling pathway GO:0030522
Any series of molecular signals initiated by a ligand binding to an receptor located within a cell.
1 P42227 (/ISO)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P52631 (/IEP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P42227 (/ISO)
Cellular response to hormone stimulus GO:0032870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 P42227 (/ISO)
Leptin-mediated signaling pathway GO:0033210
A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
1 P42227 (/IMP)
Leptin-mediated signaling pathway GO:0033210
A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
1 P42227 (/ISO)
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
1 P52631 (/IDA)
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
1 P42227 (/ISO)
MiRNA mediated inhibition of translation GO:0035278
The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs
1 P42227 (/ISO)
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
1 P42227 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P52631 (/IEP)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
1 P42227 (/IMP)
Eating behavior GO:0042755
The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.
1 P42227 (/IMP)
MRNA transcription by RNA polymerase II GO:0042789
The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
1 P42227 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P42227 (/ISO)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
1 P52631 (/IEP)
Cellular response to leptin stimulus GO:0044320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.
1 P42227 (/ISO)
Response to leptin GO:0044321
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].
1 P42227 (/IMP)
Response to leptin GO:0044321
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].
1 P42227 (/ISO)
Positive regulation of interleukin-6 biosynthetic process GO:0045410
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.
1 P52631 (/IGI)
Positive regulation of interleukin-6 biosynthetic process GO:0045410
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.
1 P42227 (/ISO)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P52631 (/IEP)
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
1 P42227 (/ISO)
Positive regulation of Notch signaling pathway GO:0045747
Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
1 P42227 (/IMP)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 P42227 (/IDA)
Negative regulation of glycolytic process GO:0045820
Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.
1 P42227 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P42227 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P42227 (/ISO)
Regulation of mitochondrial membrane permeability GO:0046902
Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.
1 P52631 (/IMP)
Regulation of mitochondrial membrane permeability GO:0046902
Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.
1 P42227 (/ISO)
Astrocyte differentiation GO:0048708
The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
1 P42227 (/IMP)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
1 P52631 (/EXP)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
1 P52631 (/IDA)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
1 P52631 (/IMP)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
1 P42227 (/ISO)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 P52631 (/IGI)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 P42227 (/ISO)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 P42227 (/ISO)
Radial glial cell differentiation GO:0060019
The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
1 P42227 (/IMP)
Regulation of feeding behavior GO:0060259
Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.
1 P42227 (/IMP)
Growth hormone receptor signaling pathway GO:0060396
The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.
1 P42227 (/ISO)
Growth hormone receptor signaling pathway via JAK-STAT GO:0060397
The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
1 P42227 (/ISO)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 P52631 (/IMP)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 P42227 (/ISO)
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P42227 (/ISO)
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
1 P52631 (/IDA)
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
1 P42227 (/ISO)
Cellular response to interleukin-6 GO:0071354
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
1 O13133 (/IDA)
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P52631 (/IDA)
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P42227 (/ISO)
T-helper 17 cell lineage commitment GO:0072540
The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
1 P42227 (/IMP)
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
1 P42227 (/IMP)
Postsynapse to nucleus signaling pathway GO:0099527
A series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
1 P52631 (/IDA)
Postsynapse to nucleus signaling pathway GO:0099527
A series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
1 P42227 (/ISO)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 P52631 (/IMP)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 P42227 (/ISO)
Positive regulation of growth factor dependent skeletal muscle satellite cell proliferation GO:1902728
Any process that activates or increases the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta.
1 P52631 (/IMP)
Positive regulation of growth factor dependent skeletal muscle satellite cell proliferation GO:1902728
Any process that activates or increases the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta.
1 P42227 (/ISO)
Positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895
Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription mediated by RNA polymerase II.
1 P42227 (/IMP)
Positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895
Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription mediated by RNA polymerase II.
1 P42227 (/ISO)
Positive regulation of metalloendopeptidase activity GO:1904685
Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity.
1 P42227 (/ISO)
Positive regulation of vascular endothelial cell proliferation GO:1905564
Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation.
1 P42227 (/IDA)
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
1 P42227 (/ISO)
Negative regulation of stem cell differentiation GO:2000737
Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation.
1 P42227 (/IMP)
Positive regulation of ATP biosynthetic process GO:2001171
Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process.
1 P52631 (/IMP)
Positive regulation of ATP biosynthetic process GO:2001171
Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process.
1 P42227 (/ISO)
Negative regulation of neuron migration GO:2001223
Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.
1 P42227 (/IGI)

There are 36 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
32 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(22 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
32 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(22 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
31 P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS) P40763 (/ISS)
(21 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
27 G8JLH9 (/IDA) G8JLH9 (/IDA) G8JLH9 (/IDA) G8JLH9 (/IDA) G8JLH9 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(17 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
27 G8JLH9 (/IDA) G8JLH9 (/IDA) G8JLH9 (/IDA) G8JLH9 (/IDA) G8JLH9 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(17 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
24 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(14 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
24 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(14 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
24 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(14 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
23 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(13 more)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
22 P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA) P40763 (/IDA)
(12 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
22 P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS) P40763 (/TAS)
(12 more)
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
22 P40763 (/IC) P40763 (/IC) P40763 (/IC) P40763 (/IC) P40763 (/IC) P40763 (/IC) P40763 (/IC) P40763 (/IC) P40763 (/IC) P40763 (/IC)
(12 more)
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
22 P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP) P40763 (/IMP)
(12 more)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 P42227 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P42227 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P42227 (/ISO)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
1 P42227 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P42227 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P52631 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P42227 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 P52631 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 P42227 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P42227 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P42227 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 P52631 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 P42227 (/ISO)
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
1 P42227 (/ISO)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
1 P52631 (/EXP)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
1 P52631 (/IDA)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
1 P52631 (/IMP)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
1 P42227 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P52631 (/EXP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P52631 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P52631 (/IMP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P42227 (/ISO)