# STOCKHOLM 1.0 #=GF ID 1.10.510.10/FF/000938 #=GF DE eIF-2-alpha kinase GCN2 #=GF AC 1.10.510.10/FF/000938 #=GF TP FunFam #=GF DR CATH: v4.3 #=GF DR DOPS: 75.041 #=GS Q558U1/1231-1497 AC Q558U1 #=GS Q558U1/1231-1497 OS Dictyostelium discoideum #=GS Q558U1/1231-1497 DE Probable serine/threonine-protein kinase ifkA #=GS Q558U1/1231-1497 DR ORG; Eukaryota; Dictyosteliales; Dictyosteliaceae; Dictyostelium; Dictyostelium discoideum; #=GS Q558U1/1231-1497 DR GO; GO:0004694; GO:0005524; GO:0006417; GO:0006446; GO:0006468; GO:0019933; GO:0031152; GO:0031158; GO:0031589; GO:0048255; GO:0098609; #=GS Q558U1/1231-1497 DR EC; 2.7.11.1; #=GS A0A0B4KHX7/672-914 AC A0A0B4KHX7 #=GS A0A0B4KHX7/672-914 OS Drosophila melanogaster #=GS A0A0B4KHX7/672-914 DE Gcn2, isoform C #=GS A0A0B4KHX7/672-914 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster; #=GS A0A0B4KHX7/672-914 DR GO; GO:0004694; GO:0005829; GO:0006468; GO:0010998; GO:0045793; #=GS O61651/670-910 AC O61651 #=GS O61651/670-910 OS Drosophila melanogaster #=GS O61651/670-910 DE eIF-2alpha kinase #=GS O61651/670-910 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster; #=GS O61651/670-910 DR GO; GO:0045793; #=GS Q550L8/331-597 AC Q550L8 #=GS Q550L8/331-597 OS Dictyostelium discoideum #=GS Q550L8/331-597 DE Probable serine/threonine-protein kinase ifkB #=GS Q550L8/331-597 DR ORG; Eukaryota; Dictyosteliales; Dictyosteliaceae; Dictyostelium; Dictyostelium discoideum; #=GS Q550L8/331-597 DR GO; GO:0004694; GO:0005524; GO:0006468; GO:0031589; GO:0098609; #=GS Q550L8/331-597 DR EC; 2.7.11.1; #=GS O01712/670-910 AC O01712 #=GS O01712/670-910 OS Drosophila melanogaster #=GS O01712/670-910 DE Eukaryotic initiation factor eIF-2 alpha kinase #=GS O01712/670-910 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster; #=GS O01712/670-910 DR GO; GO:0045793; #=GS Q9V9X8/670-910 AC Q9V9X8 #=GS Q9V9X8/670-910 OS Drosophila melanogaster #=GS Q9V9X8/670-910 DE AT10027p #=GS Q9V9X8/670-910 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster; #=GS Q9V9X8/670-910 DR GO; GO:0045793; #=GS Q7YU14/393-634 AC Q7YU14 #=GS Q7YU14/393-634 OS Drosophila melanogaster #=GS Q7YU14/393-634 DE LD22885p #=GS Q7YU14/393-634 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster; #=GS Q7YU14/393-634 DR GO; GO:0045793; #=GS B3RL12/499-759 AC B3RL12 #=GS B3RL12/499-759 OS Trichoplax adhaerens #=GS B3RL12/499-759 DE Uncharacterized protein #=GS B3RL12/499-759 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax adhaerens; #=GS W4ZBZ0/645-883 AC W4ZBZ0 #=GS W4ZBZ0/645-883 OS Strongylocentrotus purpuratus #=GS W4ZBZ0/645-883 DE Uncharacterized protein #=GS W4ZBZ0/645-883 DR ORG; Eukaryota; Metazoa; Echinodermata; Echinozoa; Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae; Strongylocentrotus; Strongylocentrotus purpuratus; #=GS H2Y1U3/277-545 AC H2Y1U3 #=GS H2Y1U3/277-545 OS Ciona intestinalis #=GS H2Y1U3/277-545 DE Uncharacterized protein #=GS H2Y1U3/277-545 DR ORG; Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona; Phlebobranchia; Cionidae; Ciona; Ciona intestinalis; #=GS A0A1W4UJT0/667-912 AC A0A1W4UJT0 #=GS A0A1W4UJT0/667-912 OS Drosophila ficusphila #=GS A0A1W4UJT0/667-912 DE eIF-2-alpha kinase GCN2 #=GS A0A1W4UJT0/667-912 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; ficusphila subgroup; Drosophila ficusphila; #=GS B3P7P8/670-904 AC B3P7P8 #=GS B3P7P8/670-904 OS Drosophila erecta #=GS B3P7P8/670-904 DE GG11806 #=GS B3P7P8/670-904 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila erecta; #=GS B4PND8/670-909 AC B4PND8 #=GS B4PND8/670-909 OS Drosophila yakuba #=GS B4PND8/670-909 DE Uncharacterized protein #=GS B4PND8/670-909 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila yakuba; #=GS B4I024/668-904 AC B4I024 #=GS B4I024/668-904 OS Drosophila sechellia #=GS B4I024/668-904 DE GM12941 #=GS B4I024/668-904 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila sechellia; #=GS B4QSM4/670-906 AC B4QSM4 #=GS B4QSM4/670-906 OS Drosophila simulans #=GS B4QSM4/670-906 DE GD21576 #=GS B4QSM4/670-906 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila simulans; #=GF SQ 15 Q558U1/1231-1497 -------------------TFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQMEYCSKKTLKTLIDNVGGIAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQNVKIGDFGLATSGAPVSKSDDLNSSTSNTANNINLSSSTNSTAQQTPMWDLNDENLSMTGGVGTPFYCCPEILEKNT-K-HYGTKVDMYSLGIIFFEMCF-QFQTQMERSNILRDLR-DNLKFPPG-FES---TKPDQTQIIRSLLSRDPTQRPSTKQLLESGLLP-SKMEDDILKEAIKT--------------------- A0A0B4KHX7/672-914 -------------------VYDDEEQED--------STRGKTNSPKPLMQVMYIQMEFCEKCTLRTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHD-AAPA--PVNQITSAE--DGTGT---------------GKVGTTLYVAPELTGNAS-KSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKD--PKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLEANELQEML----------------------- O61651/670-910 -------------------VYDDEEQED--------STRGKTNSPKPLMQVMYIQMEFCEKCTLRTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHD-AAPA--PVNQITSAE--DGTGT---------------GKVGTTLYVAPELTGNAS-KSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKD--PKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLEANELQE------------------------- Q550L8/331-597 -------------------TFDFQDKSRVVSNNSKLSTSSSRKKPPKETHTLYIQMEYCSKKTLKTLIDNVGGIAEEEAFRLLRQIVEGLNHIHSQQIIHRDLKPANIFIDNEQNVKIGDFGLATSGAPVSKSDDLNSSTSNAANNINLSSSTNSTAQQTPMWDLNDENLSMTGGVGTPFYCCPEILEKNT-K-HYGTKVDMYSLGIIFFEMCF-QFQTQMERSNILRDLR-DNLKFPPG-FES---TKPDQTQIIRSLLSRDPTQRPSTKQLLESGLLP-SKMEDDILKEAIKT--------------------- O01712/670-910 -------------------VYDDEEQED--------STRGKTNSPRPLMQVMYIQMEFCEKCTLRTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHD-AAPA--PVNQITSAE--DGTGT---------------GKVGTTLYVAPELTGNAS-KSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKD--PKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLEANELQE------------------------- Q9V9X8/670-910 -------------------VYDDEEQED--------STRGKTNSPKPLMQVMYIQMEFCEKCTLRTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHD-AAPA--PVNQITSAE--DGTGT---------------GKVGTTLYVAPELTGNAS-KSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKD--PKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLEANELQE------------------------- Q7YU14/393-634 -------------------VYDDEEQED--------STRGKTNSPKPLMQVMYIQMEFCEKCTLRTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHD-AAPA--PVNQITSAE--DGTGT---------------GKVGTTLYVAPELTGNAS-KSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKD--PKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLEANELQEM------------------------ B3RL12/499-759 RIQLITKPEVSSSMDFIEFVRDDEDDAE--------CEDDDS------DEFIVDKMEYCEKNNLRTVIDEGIYKNEEKLWQYFGEIVQGLAYIHEQGILHRDLKPGNVFIDSKDQVKIGDFGLALEHPMFSRSNS-VG------NNLKSME--DGSFS--A-------YDHNSGAVGTTLYRAPEITQSSVLKFRYDEKVDMYSLGIIFFEMCHPQFDTGMERYSVIMKVRQSDIILPET-FQDSIAAFETKVKLIRMLLNHDPKKRPTARDLFTSRLIP-SEVDDQQCELVIQQ--------------------- W4ZBZ0/645-883 -----------------------KEEDI--------SEDNPVFSP---VQYLYIQMEFCEKSTLRTAIDAGMYEDKRRLWTHFREIIEGLAHIHLQGMIHRDLKPVNIFLDSNDFVKIGDFGLATSEQMAGALTS-EVSC--HNRLTDSSH--SGEAT--P-------GNHLTGKVGTALYVAPELC-KAR-IGHYNQKVDLYSLGIIFFEMCYRSLSTGMERVKILGQIRQESIQLPED-FDE--VRNTNENAIVHWLLNHDPKERPTSQELLESKLLPPPQMEDARLQDM------------------------ H2Y1U3/277-545 --------------------EESTNDGKTSRSEETTVTSSASSKSLVTQRFLYIQMEYCEKSTLRQTIDAGVCNEPERMWRLFREILEGLVHVHEQGMIHRDLKPQNIFLDKNDHVKIGDFGLATAQARVTLADS--------SEEISKSETGDSVYS---------------GVVGTALYVAPELMVTGK-RSLYSQKVDIYSVGIIFFEMSFPGIQTKMERVKVLGNLRTSSITFPSD-FDE--AAMPREAEITRWCLDHVPNKRPTASELLKCRLVPTPVLEESNVLEAVREMLSNPDSKPYRLVMDEVFNQP A0A1W4UJT0/667-912 -----------------VAVYDDEEEED--------STTGKTSSPRPLMQVMYIQMEFCEKCTLRTAIDDNLYDDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHEYAAPA--PVHQITSAE--DGTGT---------------GKVGTTLYVAPELTGNAS-KSVYNQKV--HTLGIILFEMCQPPFDTSMERAQTIMALRNVAINIPNSMLKD--PKYEKTVKMLQWLLNHDPAQRPTAEELLTSDLVPPAQLEANELQEMLRH--------------------- B3P7P8/670-904 -------------------VYDDEEQEE--------STRGRTNSPRPLMQVMYIQMEFCEKCTLRTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHD-TAPA--PVNQITSAE--DGTGT---------------GKVGTTLYVAPELTGNAS-KSVYNQKVDMYTLGVILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKD--PKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLE------------------------------- B4PND8/670-909 -------------------VYDDEEQED--------STRGKTNSPKPLMQVMYIQMEFCEKCTLRTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHD-TAPA--PVHQITSAE--DGTGT---------------GKVGTTLYVAPELTGNAS-KSVYNQKVDMYTLGVILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKD--PKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLEANELQ-------------------------- B4I024/668-904 -----------------VAVYDDEEQDD--------STRDKSNSPRPLMQVMYIQMEFCEKCTLRTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHD-AAPA--PVNQLTSAE--DGTGT---------------GKVGTTLYVAPELTGNAS-KSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKD--PKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLE------------------------------- B4QSM4/670-906 -------------------VYDDEEQED--------STRGKSNSPRPLMQVMYIQMEFCEKCTLRTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHD-AAPA--PVNQITSAE--DGTGT---------------GKVGTTLYVAPELTGNAS-KSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKD--PKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLEAN----------------------------- #=GC scorecons 0000000000000000000336356444000000006644343452223546777997969479775994444454665666777957995889496779999994989695464799999999744345445450333300336464555006653500000000000000094999579569964345406339559986867989699974446594999445644793357459441655003434445565647967794699664697374969355684324332110000000000000000000000 #=GC scorecons_70 _____________________*__*___________**______________*********_****_**__________*******_***_***_**********_*****__*_**********_____________________*______**__________________*_***_**_****______*__*__*****_*********___*_*_***___*__**___*__*___*________________**_***_*****_***_*_*_*____*_______________________________ #=GC scorecons_80 ____________________________________________________*******_*_****_**______________*_*_***_***_*_********_***_*_____*********________________________________________________*_***__*__**__________*__***_*_****_****_____*_***_______*______*____________________**__**__**____**_*_*_*____*_______________________________ #=GC scorecons_90 _______________________________________________________**_*_*__*___**________________*__**_***_*___******_***_*_____********_________________________________________________*_***__*__**__________*__**__*__***_***______*_***_______*______*_____________________*___*__**____*____*_*____*_______________________________ //