The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 63: Mitogen-activated protein kinase 14

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 27 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MAP kinase activity GO:0004707
Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
49 O02812 (/ISS) O02812 (/ISS) O02812 (/ISS) O62618 (/ISS) O62618 (/ISS) P47811 (/ISS) P47812 (/ISS) P47812 (/ISS) P70618 (/ISS) Q5U421 (/ISS)
(39 more)
MAP kinase activity GO:0004707
Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
31 A0A0G2KB06 (/IDA) D4A3U7 (/IDA) O61443 (/IDA) O62618 (/IDA) O62618 (/IDA) P47811 (/IDA) P70618 (/IDA) Q15759 (/IDA) Q15759 (/IDA) Q16539 (/IDA)
(21 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
22 P47811 (/IPI) P70618 (/IPI) Q15759 (/IPI) Q15759 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI)
(12 more)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
19 Q15759 (/TAS) Q15759 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(9 more)
MAP kinase kinase activity GO:0004708
Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
17 Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(7 more)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
17 Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI)
(7 more)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
17 Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI)
(7 more)
Mitogen-activated protein kinase p38 binding GO:0048273
Interacting selectively and non-covalently with mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation.
17 Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI) Q16539 (/IPI)
(7 more)
NFAT protein binding GO:0051525
Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system.
17 Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS)
(7 more)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
3 O61443 (/IDA) P47811 (/IDA) Q17446 (/IDA)
MAP kinase activity GO:0004707
Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
3 P70618 (/TAS) Q15759 (/TAS) Q15759 (/TAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
3 A0A0G2KB06 (/IDA) D4A3U7 (/IDA) P70618 (/IDA)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
2 P47811 (/IDA) Q17446 (/IDA)
MAP kinase activity GO:0004707
Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
2 O62618 (/IGI) O62618 (/IGI)
MAP kinase activity GO:0004707
Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
2 P47811 (/ISO) Q9WUI1 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 P47811 (/ISO) Q9WUI1 (/ISO)
SAP kinase activity GO:0016909
Catalysis of the phosphorylation of proteins. A family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. Strongly activated by stress signals such as heat or osmotic shock, DNA-damaging agents, inhibitors of protein synthesis and pro-inflammatory cytokines.
2 O62618 (/TAS) O62618 (/TAS)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 O61443 (/NAS)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P70618 (/IPI)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P47811 (/ISO)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 Q17446 (/IPI)
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 P47811 (/IDA)
SAP kinase activity GO:0016909
Catalysis of the phosphorylation of proteins. A family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. Strongly activated by stress signals such as heat or osmotic shock, DNA-damaging agents, inhibitors of protein synthesis and pro-inflammatory cytokines.
1 O61443 (/NAS)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P47811 (/ISO)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
1 P47811 (/ISO)
Mitogen-activated protein kinase p38 binding GO:0048273
Interacting selectively and non-covalently with mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation.
1 P47811 (/ISO)
NFAT protein binding GO:0051525
Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system.
1 P47811 (/IPI)

There are 174 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
54 O02812 (/ISS) O02812 (/ISS) O02812 (/ISS) P47812 (/ISS) P47812 (/ISS) P70618 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS)
(44 more)
Positive regulation of myotube differentiation GO:0010831
Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
54 O02812 (/ISS) O02812 (/ISS) O02812 (/ISS) P47812 (/ISS) P47812 (/ISS) P70618 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS)
(44 more)
P38MAPK cascade GO:0038066
An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
54 O02812 (/ISS) O02812 (/ISS) O02812 (/ISS) P47812 (/ISS) P47812 (/ISS) P70618 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS)
(44 more)
Positive regulation of myoblast differentiation GO:0045663
Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
54 O02812 (/ISS) O02812 (/ISS) O02812 (/ISS) P47812 (/ISS) P47812 (/ISS) P70618 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS)
(44 more)
Positive regulation of myoblast fusion GO:1901741
Any process that activates or increases the frequency, rate or extent of myoblast fusion.
54 O02812 (/ISS) O02812 (/ISS) O02812 (/ISS) P47812 (/ISS) P47812 (/ISS) P70618 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS)
(44 more)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
46 O02812 (/ISS) O02812 (/ISS) O02812 (/ISS) P47811 (/ISS) P47812 (/ISS) P47812 (/ISS) P70618 (/ISS) Q5U421 (/ISS) Q5ZIK8 (/ISS) Q640H9 (/ISS)
(36 more)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
20 P47811 (/IMP) Q15759 (/IMP) Q15759 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP)
(10 more)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
19 Q15759 (/TAS) Q15759 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(9 more)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
19 Q15759 (/TAS) Q15759 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(9 more)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
19 P47811 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA)
(9 more)
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
19 Q15759 (/TAS) Q15759 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(9 more)
Regulation of DNA-binding transcription factor activity GO:0051090
Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
19 Q15759 (/TAS) Q15759 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(9 more)
Positive regulation of muscle cell differentiation GO:0051149
Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.
19 Q15759 (/TAS) Q15759 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(9 more)
Cellular response to virus GO:0098586
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
19 Q15759 (/IMP) Q15759 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP)
(9 more)
Regulation of signal transduction by p53 class mediator GO:1901796
Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.
19 Q15759 (/TAS) Q15759 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(9 more)
Positive regulation of interleukin-12 secretion GO:2001184
Any process that activates or increases the frequency, rate or extent of interleukin-12 secretion.
19 Q15759 (/IMP) Q15759 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP)
(9 more)
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
18 P47811 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP)
(8 more)
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
17 Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(7 more)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
17 Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(7 more)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
17 Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(7 more)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
17 Q16539 (/IGI) Q16539 (/IGI) Q16539 (/IGI) Q16539 (/IGI) Q16539 (/IGI) Q16539 (/IGI) Q16539 (/IGI) Q16539 (/IGI) Q16539 (/IGI) Q16539 (/IGI)
(7 more)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
17 Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS)
(7 more)
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
17 Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS)
(7 more)
Positive regulation of cyclase activity GO:0031281
Any process that activates or increases the activity of a cyclase.
17 Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP)
(7 more)
Cellular response to vascular endothelial growth factor stimulus GO:0035924
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.
17 Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP)
(7 more)
Signal transduction in response to DNA damage GO:0042770
A cascade of processes induced by the detection of DNA damage within a cell.
17 Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP)
(7 more)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
17 Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(7 more)
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
17 Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP)
(7 more)
3'-UTR-mediated mRNA stabilization GO:0070935
An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
17 Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(7 more)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
17 Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA)
(7 more)
Cellular response to lipoteichoic acid GO:0071223
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.
17 Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP)
(7 more)
Cellular response to ionizing radiation GO:0071479
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
17 Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP)
(7 more)
Stress-induced premature senescence GO:0090400
A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays.
17 Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP)
(7 more)
Regulation of cytokine production involved in inflammatory response GO:1900015
Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.
17 Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA) Q16539 (/IDA)
(7 more)
Positive regulation of reactive oxygen species metabolic process GO:2000379
Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.
17 Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP) Q16539 (/IMP)
(7 more)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
6 A0A0G2KB06 (/IDA) D4A3U7 (/IDA) O61443 (/IDA) P47811 (/IDA) P70618 (/IDA) Q17446 (/IDA)
P38MAPK cascade GO:0038066
An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
5 P47811 (/IDA) Q90336 (/IDA) Q9DGE2 (/IDA) Q9DGE2 (/IDA) Q9I958 (/IDA)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
4 O61443 (/IMP) O62618 (/IMP) O62618 (/IMP) Q17446 (/IMP)
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
4 O61443 (/IMP) O62618 (/IMP) O62618 (/IMP) Q17446 (/IMP)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
3 O61443 (/IDA) O62618 (/IDA) O62618 (/IDA)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
3 O61443 (/NAS) O62618 (/NAS) O62618 (/NAS)
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
3 O61443 (/IGI) O62618 (/IGI) O62618 (/IGI)
Smooth muscle contraction GO:0006939
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.
3 O02812 (/TAS) O02812 (/TAS) O02812 (/TAS)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
3 O62618 (/IDA) O62618 (/IDA) Q17446 (/IDA)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
3 O61443 (/IMP) O62618 (/IMP) O62618 (/IMP)
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
3 O02812 (/IDA) O02812 (/IDA) O02812 (/IDA)
Cellular response to reactive oxygen species GO:0034614
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
3 O61443 (/IDA) O62618 (/IDA) O62618 (/IDA)
Paracrine signaling GO:0038001
The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other.
3 O61443 (/IGI) O62618 (/IGI) O62618 (/IGI)
Positive regulation of phosphorylation GO:0042327
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.
3 O02812 (/NAS) O02812 (/NAS) O02812 (/NAS)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
3 O61443 (/IMP) O62618 (/IMP) O62618 (/IMP)
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
3 O61443 (/IMP) O62618 (/IMP) O62618 (/IMP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
3 O61443 (/IMP) O62618 (/IMP) O62618 (/IMP)
Positive regulation of cell size GO:0045793
Any process that increases cell size.
3 O61443 (/IGI) O62618 (/IGI) O62618 (/IGI)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P47811 (/IMP) P70618 (/IMP) Q17446 (/IMP)
Regulation of adult chitin-containing cuticle pigmentation GO:0048082
Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism.
3 O61443 (/IGI) O62618 (/IGI) O62618 (/IGI)
Cell motility GO:0048870
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
3 O02812 (/TAS) O02812 (/TAS) O02812 (/TAS)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
3 O02812 (/TAS) O02812 (/TAS) O02812 (/TAS)
Stress-activated MAPK cascade GO:0051403
A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.
3 P70618 (/IDA) Q15759 (/IDA) Q15759 (/IDA)
Cellular response to arsenic-containing substance GO:0071243
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
3 O61443 (/IDA) O62618 (/IDA) O62618 (/IDA)
Cellular response to cadmium ion GO:0071276
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
3 O61443 (/IDA) O62618 (/IDA) O62618 (/IDA)
Reactive oxygen species metabolic process GO:0072593
The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
3 O61443 (/IGI) O62618 (/IGI) O62618 (/IGI)
Regulation of cellular response to oxidative stress GO:1900407
Any process that modulates the frequency, rate or extent of cellular response to oxidative stress.
3 O61443 (/IMP) O62618 (/IMP) O62618 (/IMP)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
2 O62618 (/ISS) O62618 (/ISS)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
2 Q9DGE2 (/IMP) Q9DGE2 (/IMP)
Mucosal immune response GO:0002385
An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract.
2 O62618 (/IMP) O62618 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 P47811 (/ISO) Q9WUI1 (/ISO)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
2 O62618 (/IDA) O62618 (/IDA)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
2 O62618 (/IMP) O62618 (/IMP)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 O62618 (/IMP) O62618 (/IMP)
Negative regulation of antimicrobial humoral response GO:0008348
Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response.
2 O62618 (/IMP) O62618 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P47811 (/ISO) Q9WUI1 (/ISO)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
2 P47811 (/IDA) Q17446 (/IDA)
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
2 Q9DGE2 (/IMP) Q9DGE2 (/IMP)
Cellular response to UV GO:0034644
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
2 Q9DGE2 (/IDA) Q9DGE2 (/IDA)
P38MAPK cascade GO:0038066
An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
2 P47811 (/IMP) Q17446 (/IMP)
Embryonic cleavage GO:0040016
The first few specialized divisions of an activated animal egg.
2 Q9DGE2 (/IDA) Q9DGE2 (/IDA)
Regulation of collateral sprouting in absence of injury GO:0048696
Any process that modulates the frequency, rate or extent of collateral sprouting in the absence of injury.
2 Q9DGE2 (/IGI) Q9DGE2 (/IGI)
Regulation of collateral sprouting in absence of injury GO:0048696
Any process that modulates the frequency, rate or extent of collateral sprouting in the absence of injury.
2 Q9DGE2 (/IMP) Q9DGE2 (/IMP)
Stress-activated MAPK cascade GO:0051403
A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.
2 P47811 (/ISO) Q9WUI1 (/ISO)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
2 Q15759 (/IDA) Q15759 (/IDA)
Cellular response to virus GO:0098586
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
2 P47811 (/ISO) Q9WUI1 (/ISO)
Positive regulation of interleukin-12 secretion GO:2001184
Any process that activates or increases the frequency, rate or extent of interleukin-12 secretion.
2 P47811 (/ISO) Q9WUI1 (/ISO)
DNA damage checkpoint GO:0000077
A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
1 P47811 (/IMP)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
1 Q17446 (/IGI)
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
1 Q17446 (/IEP)
Response to superoxide GO:0000303
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion.
1 Q17446 (/IEP)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
1 P47811 (/IGI)
Cartilage condensation GO:0001502
The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.
1 P47811 (/IMP)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 P47811 (/IMP)
Placenta development GO:0001890
The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
1 P47811 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 O61443 (/IGI)
Chondrocyte differentiation GO:0002062
The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.
1 P47811 (/IDA)
Chondrocyte differentiation GO:0002062
The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.
1 P47811 (/IMP)
Positive regulation of antimicrobial peptide production GO:0002225
Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production.
1 Q17446 (/IMP)
Positive regulation of cytokine secretion involved in immune response GO:0002741
Any process that activates or increases the frequency, rate, or extent of cytokine secretion contributing to an immune response.
1 P47811 (/IMP)
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
1 P47811 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P47811 (/IDA)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P47811 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 P47811 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 O61443 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 P70618 (/TAS)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
1 O61443 (/IMP)
Hyperosmotic response GO:0006972
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
1 Q17446 (/IGI)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 P47811 (/IDA)
Transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P47811 (/IGI)
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
1 O61443 (/IDA)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
1 P47811 (/IMP)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 O61443 (/IMP)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
1 O61443 (/IDA)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 O61443 (/IGI)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 O61443 (/IMP)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 P70618 (/IEP)
Positive regulation of macrophage chemotaxis GO:0010759
Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.
1 P47811 (/IMP)
Positive regulation of myotube differentiation GO:0010831
Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
1 P47811 (/IMP)
Programmed cell death GO:0012501
A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
1 Q17446 (/IMP)
Fatty acid oxidation GO:0019395
The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
1 P47811 (/IMP)
Regulation of ossification GO:0030278
Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
1 P47811 (/IDA)
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
1 P47811 (/IMP)
Regulation of BMP signaling pathway GO:0030510
Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.
1 O61443 (/IDA)
Positive regulation of cyclase activity GO:0031281
Any process that activates or increases the activity of a cyclase.
1 P47811 (/ISO)
Lipopolysaccharide-mediated signaling pathway GO:0031663
A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
1 P47811 (/IDA)
Response to muramyl dipeptide GO:0032495
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.
1 P47811 (/IDA)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P47811 (/IDA)
Cellular response to UV GO:0034644
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
1 Q9DGE1 (/ISS)
Behavioral response to nicotine GO:0035095
Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus.
1 Q17446 (/IMP)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 P47811 (/ISO)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 P70618 (/TAS)
Cellular response to vascular endothelial growth factor stimulus GO:0035924
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.
1 P47811 (/ISO)
Response to muscle stretch GO:0035994
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length.
1 P47811 (/IMP)
P38MAPK cascade GO:0038066
An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 Q17446 (/IEP)
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
1 O61443 (/IMP)
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
1 P47811 (/IMP)
Signal transduction in response to DNA damage GO:0042770
A cascade of processes induced by the detection of DNA damage within a cell.
1 P47811 (/ISO)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
1 Q17446 (/IMP)
Regulation of innate immune response GO:0045088
Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
1 O61443 (/IDA)
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
1 P47811 (/ISO)
Positive regulation of myoblast differentiation GO:0045663
Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
1 P47811 (/IMP)
Positive regulation of cell size GO:0045793
Any process that increases cell size.
1 O61443 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P47811 (/ISO)
Positive regulation of glucose import GO:0046326
Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
1 P47811 (/IMP)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 P70618 (/IDA)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 P47811 (/ISO)
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P47811 (/ISO)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
1 Q17446 (/IGI)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
1 Q17446 (/IMP)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
1 Q17446 (/IMP)
Striated muscle cell differentiation GO:0051146
The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.
1 P47811 (/IGI)
Stress-activated MAPK cascade GO:0051403
A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.
1 Q9WUI1 (/ISS)
Regulation of cardiac muscle cell proliferation GO:0060043
Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation.
1 Q9WUI1 (/IGI)
Negative regulation of cardiac muscle cell proliferation GO:0060044
Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation.
1 Q9WUI1 (/IMP)
Positive regulation of cardiac muscle cell proliferation GO:0060045
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.
1 P47811 (/IGI)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P47811 (/ISO)
Cellular response to lipoteichoic acid GO:0071223
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.
1 P47811 (/ISO)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 Q9WUI1 (/ISO)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 P47811 (/IDA)
Cellular response to ionizing radiation GO:0071479
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
1 P47811 (/ISO)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 P47811 (/IMP)
Positive regulation of brown fat cell differentiation GO:0090336
Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
1 P47811 (/IMP)
Stress-induced premature senescence GO:0090400
A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays.
1 P47811 (/ISO)
Response to nematicide GO:0093002
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nematicide stimulus. Nematicides are chemicals used to kill nematodes.
1 Q17446 (/IMP)
Regulation of synaptic membrane adhesion GO:0099179
Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.
1 P47811 (/EXP)
Regulation of synaptic membrane adhesion GO:0099179
Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.
1 P47811 (/IDA)
Regulation of synaptic membrane adhesion GO:0099179
Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.
1 P47811 (/IMP)
Regulation of cytokine production involved in inflammatory response GO:1900015
Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.
1 P47811 (/ISO)
Regulation of defense response to fungus GO:1900150
Any process that modulates the frequency, rate or extent of defense response to fungus.
1 Q17446 (/IMP)
Positive regulation of protein localization to nucleus GO:1900182
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
1 Q17446 (/IMP)
Positive regulation of defense response to bacterium GO:1900426
Any process that activates or increases the frequency, rate or extent of defense response to bacterium.
1 Q17446 (/IGI)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 Q17446 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter involved in defense response to fungus GO:1901244
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter to protect the cell or organism in response to the presence of a fungus.
1 Q17446 (/IMP)
Positive regulation of myoblast fusion GO:1901741
Any process that activates or increases the frequency, rate or extent of myoblast fusion.
1 P47811 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium GO:1902097
Any positive regulation of transcription from RNA polymerase II promoter that is involved in defense response to Gram-negative bacterium.
1 Q17446 (/IMP)
Positive regulation of metallopeptidase activity GO:1905050
Any process that activates or increases the frequency, rate or extent of metallopeptidase activity.
1 P47811 (/IMP)
Regulation of terminal button organization GO:2000331
Any process that modulates the frequency, rate or extent of terminal button organization.
1 O61443 (/IMP)
Positive regulation of reactive oxygen species metabolic process GO:2000379
Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.
1 P47811 (/ISO)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
65 A0A024RD15 (/IDA) A0A024RD15 (/IDA) A0A024RD15 (/IDA) A0A024RD15 (/IDA) A0A024RD15 (/IDA) A0A024RD15 (/IDA) A0A024RD15 (/IDA) A0A024RD15 (/IDA) A0A024RD15 (/IDA) A0A024RD15 (/IDA)
(55 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
51 O02812 (/ISS) O02812 (/ISS) O02812 (/ISS) P70618 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS)
(41 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
51 O02812 (/ISS) O02812 (/ISS) O02812 (/ISS) P70618 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS) Q16539 (/ISS)
(41 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
22 P47811 (/TAS) P70618 (/TAS) Q15759 (/TAS) Q15759 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(12 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
21 P47811 (/TAS) Q15759 (/TAS) Q15759 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(11 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
17 Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(7 more)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
17 Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(7 more)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
17 Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS) Q16539 (/TAS)
(7 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 O62618 (/IDA) O62618 (/IDA) P47811 (/IDA) P70618 (/IDA) Q17446 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P47811 (/IDA) P70618 (/IDA) Q17446 (/IDA)
Spindle pole GO:0000922
Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
1 P47811 (/IDA)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 P47811 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P47811 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P47811 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P47811 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P47811 (/ISO)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 P47811 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P47811 (/EXP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P47811 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P47811 (/IMP)