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CATH Superfamily 1.10.357.10

Tetracycline Repressor, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Tetracycline Repressor, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: TetR family transcriptional regulator

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 33 Q4KFB4 (/IDA) Q4KFB4 (/IDA) Q4KFB4 (/IDA) Q4KFB4 (/IDA) Q4KFB4 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA)
(23 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 33 Q4KFB4 (/IDA) Q4KFB4 (/IDA) Q4KFB4 (/IDA) Q4KFB4 (/IDA) Q4KFB4 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA)
(23 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 28 Q87ZC1 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA) Q88KZ5 (/IDA) Q88KZ5 (/IDA)
(18 more)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
 12 Q9HZJ9 (/IDA) Q9HZJ9 (/IDA) Q9HZJ9 (/IDA) Q9HZJ9 (/IDA) Q9HZJ9 (/IDA) Q9HZJ9 (/IDA) Q9HZJ9 (/IDA) Q9HZJ9 (/IDA) Q9HZJ9 (/IDA) Q9HZJ9 (/IDA)
(2 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 8 Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 8 Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 8 Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 5 Q4KFB4 (/IMP) Q4KFB4 (/IMP) Q4KFB4 (/IMP) Q4KFB4 (/IMP) Q4KFB4 (/IMP)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 5 Q4KFB4 (/IMP) Q4KFB4 (/IMP) Q4KFB4 (/IMP) Q4KFB4 (/IMP) Q4KFB4 (/IMP)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 5 Q4KFB4 (/IMP) Q4KFB4 (/IMP) Q4KFB4 (/IMP) Q4KFB4 (/IMP) Q4KFB4 (/IMP)

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 17 Q4KFB4 (/IDA) Q4KFB4 (/IDA) Q4KFB4 (/IDA) Q4KFB4 (/IDA) Q4KFB4 (/IDA) Q9HZJ9 (/IDA) Q9HZJ9 (/IDA) Q9HZJ9 (/IDA) Q9HZJ9 (/IDA) Q9HZJ9 (/IDA)
(7 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 12 Q9HZJ9 (/EXP) Q9HZJ9 (/EXP) Q9HZJ9 (/EXP) Q9HZJ9 (/EXP) Q9HZJ9 (/EXP) Q9HZJ9 (/EXP) Q9HZJ9 (/EXP) Q9HZJ9 (/EXP) Q9HZJ9 (/EXP) Q9HZJ9 (/EXP)
(2 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
 12 Q9HZJ9 (/IMP) Q9HZJ9 (/IMP) Q9HZJ9 (/IMP) Q9HZJ9 (/IMP) Q9HZJ9 (/IMP) Q9HZJ9 (/IMP) Q9HZJ9 (/IMP) Q9HZJ9 (/IMP) Q9HZJ9 (/IMP) Q9HZJ9 (/IMP)
(2 more)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
 12 Q9HZJ9 (/IMP) Q9HZJ9 (/IMP) Q9HZJ9 (/IMP) Q9HZJ9 (/IMP) Q9HZJ9 (/IMP) Q9HZJ9 (/IMP) Q9HZJ9 (/IMP) Q9HZJ9 (/IMP) Q9HZJ9 (/IMP) Q9HZJ9 (/IMP)
(2 more)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 33 Q4KFB4 (/IDA) Q4KFB4 (/IDA) Q4KFB4 (/IDA) Q4KFB4 (/IDA) Q4KFB4 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA) Q87ZC1 (/IDA)
(23 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 8 Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI) Q88KZ5 (/IPI)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 5 Q4KFB4 (/IMP) Q4KFB4 (/IMP) Q4KFB4 (/IMP) Q4KFB4 (/IMP) Q4KFB4 (/IMP)