# STOCKHOLM 1.0 #=GF ID 1.10.1450.10/FF/000029 #=GF DE Tetraspanin #=GF AC 1.10.1450.10/FF/000029 #=GF TP FunFam #=GF DR CATH: v4.3 #=GF DR DOPS: 96.462 #=GS Q9VLH0/111-216 AC Q9VLH0 #=GS Q9VLH0/111-216 OS Drosophila melanogaster #=GS Q9VLH0/111-216 DE Tetraspanin #=GS Q9VLH0/111-216 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster; #=GS Q9VLH0/111-216 DR GO; GO:0016021; #=GS D6WNZ1/109-203 AC D6WNZ1 #=GS D6WNZ1/109-203 OS Tribolium castaneum #=GS D6WNZ1/109-203 DE Tetraspanin #=GS D6WNZ1/109-203 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga; Cucujiformia; Tenebrionoidea; Tenebrionidae; Tribolium; Tribolium castaneum; #=GS W4XEG4/110-212 AC W4XEG4 #=GS W4XEG4/110-212 OS Strongylocentrotus purpuratus #=GS W4XEG4/110-212 DE Tetraspanin #=GS W4XEG4/110-212 DR ORG; Eukaryota; Metazoa; Echinodermata; Echinozoa; Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae; Strongylocentrotus; Strongylocentrotus purpuratus; #=GS A7RNN8/98-200 AC A7RNN8 #=GS A7RNN8/98-200 OS Nematostella vectensis #=GS A7RNN8/98-200 DE Tetraspanin #=GS A7RNN8/98-200 DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; #=GS A7SZN5/109-211 AC A7SZN5 #=GS A7SZN5/109-211 OS Nematostella vectensis #=GS A7SZN5/109-211 DE Tetraspanin #=GS A7SZN5/109-211 DR ORG; Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Edwardsiidae; Nematostella; Nematostella vectensis; #=GS B3RR47/104-210 AC B3RR47 #=GS B3RR47/104-210 OS Trichoplax adhaerens #=GS B3RR47/104-210 DE Tetraspanin #=GS B3RR47/104-210 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax adhaerens; #=GS T1FN76/114-208 AC T1FN76 #=GS T1FN76/114-208 OS Helobdella robusta #=GS T1FN76/114-208 DE Tetraspanin #=GS T1FN76/114-208 DR ORG; Eukaryota; Metazoa; Annelida; Clitellata; Hirudinea; Hirudinida; Glossiphoniiformes; Glossiphoniidae; Helobdella; Helobdella robusta; #=GS E9FX18/112-200 AC E9FX18 #=GS E9FX18/112-200 OS Daphnia pulex #=GS E9FX18/112-200 DE Tetraspanin #=GS E9FX18/112-200 DR ORG; Eukaryota; Metazoa; Arthropoda; Crustacea; Branchiopoda; Phyllopoda; Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia; Daphnia pulex; #=GS Q7Q1S1/109-210 AC Q7Q1S1 #=GS Q7Q1S1/109-210 OS Anopheles gambiae #=GS Q7Q1S1/109-210 DE Tetraspanin #=GS Q7Q1S1/109-210 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Anopheles gambiae; #=GS B3RLW6/106-214 AC B3RLW6 #=GS B3RLW6/106-214 OS Trichoplax adhaerens #=GS B3RLW6/106-214 DE Tetraspanin #=GS B3RLW6/106-214 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax adhaerens; #=GS F6WHA2/112-197 AC F6WHA2 #=GS F6WHA2/112-197 OS Ciona intestinalis #=GS F6WHA2/112-197 DE Tetraspanin #=GS F6WHA2/112-197 DR ORG; Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona; Phlebobranchia; Cionidae; Ciona; Ciona intestinalis; #=GS F6Z9C2/110-209 AC F6Z9C2 #=GS F6Z9C2/110-209 OS Monodelphis domestica #=GS F6Z9C2/110-209 DE Tetraspanin #=GS F6Z9C2/110-209 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Mammalia; Didelphimorphia; Didelphidae; Didelphinae; Monodelphis; Monodelphis domestica; #=GS C3YK57/120-219 AC C3YK57 #=GS C3YK57/120-219 OS Branchiostoma floridae #=GS C3YK57/120-219 DE Tetraspanin #=GS C3YK57/120-219 DR ORG; Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae; Branchiostoma; Branchiostoma floridae; #=GS H3D1H6/106-221 AC H3D1H6 #=GS H3D1H6/106-221 OS Tetraodon nigroviridis #=GS H3D1H6/106-221 DE Tetraspanin #=GS H3D1H6/106-221 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Euteleosteomorpha; Tetraodontiformes; Tetraodontoidei; Tetradontoidea; Tetraodontidae; Tetraodon; Tetraodon nigroviridis; #=GS G1KW81/113-207 AC G1KW81 #=GS G1KW81/113-207 OS Anolis carolinensis #=GS G1KW81/113-207 DE Tetraspanin #=GS G1KW81/113-207 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Lepidosauria; Squamata; Iguania; Dactyloidae; Anolis; Anolis carolinensis; #=GS F7BE68/105-216 AC F7BE68 #=GS F7BE68/105-216 OS Xenopus tropicalis #=GS F7BE68/105-216 DE Tetraspanin #=GS F7BE68/105-216 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana; Xenopus tropicalis; #=GS A0A369SE96/104-210 AC A0A369SE96 #=GS A0A369SE96/104-210 OS Trichoplax sp. H2 #=GS A0A369SE96/104-210 DE Tetraspanin #=GS A0A369SE96/104-210 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax sp. H2; #=GS Q2TCS1/120-220 AC Q2TCS1 #=GS Q2TCS1/120-220 OS Branchiostoma belcheri tsingtauense #=GS Q2TCS1/120-220 DE Tetraspanin #=GS Q2TCS1/120-220 DR ORG; Eukaryota; Metazoa; Chordata; Cephalochordata; Branchiostomidae; Branchiostoma; Branchiostoma belcheri; Branchiostoma belcheri tsingtauense; #=GS W5NMZ4/107-216 AC W5NMZ4 #=GS W5NMZ4/107-216 OS Lepisosteus oculatus #=GS W5NMZ4/107-216 DE Tetraspanin #=GS W5NMZ4/107-216 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; Lepisosteus; Lepisosteus oculatus; #=GS H2MLK5/105-220 AC H2MLK5 #=GS H2MLK5/105-220 OS Oryzias latipes #=GS H2MLK5/105-220 DE Tetraspanin #=GS H2MLK5/105-220 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Euteleosteomorpha; Atherinomorphae; Beloniformes; Adrianichthyoidei; Adrianichthyidae; Oryziinae; Oryzias; Oryzias latipes; #=GS A0A3B3WEP5/107-222 AC A0A3B3WEP5 #=GS A0A3B3WEP5/107-222 OS Poecilia mexicana #=GS A0A3B3WEP5/107-222 DE Tetraspanin #=GS A0A3B3WEP5/107-222 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Euteleosteomorpha; Atherinomorphae; Cyprinodontiformes; Cyprinodontoidei; Poeciliidae; Poeciliinae; Poecilia; Poecilia mexicana; #=GS A0A1L8GZ38/100-211 AC A0A1L8GZ38 #=GS A0A1L8GZ38/100-211 OS Xenopus laevis #=GS A0A1L8GZ38/100-211 DE Tetraspanin #=GS A0A1L8GZ38/100-211 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus; Xenopus laevis; #=GS A0A3B3IPM7/105-220 AC A0A3B3IPM7 #=GS A0A3B3IPM7/105-220 OS Oryzias latipes #=GS A0A3B3IPM7/105-220 DE Tetraspanin #=GS A0A3B3IPM7/105-220 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Euteleosteomorpha; Atherinomorphae; Beloniformes; Adrianichthyoidei; Adrianichthyidae; Oryziinae; Oryzias; Oryzias latipes; #=GS A0A3P9KTV0/108-223 AC A0A3P9KTV0 #=GS A0A3P9KTV0/108-223 OS Oryzias latipes #=GS A0A3P9KTV0/108-223 DE Tetraspanin #=GS A0A3P9KTV0/108-223 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Euteleosteomorpha; Atherinomorphae; Beloniformes; Adrianichthyoidei; Adrianichthyidae; Oryziinae; Oryzias; Oryzias latipes; #=GS Q4SA96/100-215 AC Q4SA96 #=GS Q4SA96/100-215 OS Tetraodon nigroviridis #=GS Q4SA96/100-215 DE Tetraspanin #=GS Q4SA96/100-215 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Euteleosteomorpha; Tetraodontiformes; Tetraodontoidei; Tetradontoidea; Tetraodontidae; Tetraodon; Tetraodon nigroviridis; #=GS Q28J95/107-203 AC Q28J95 #=GS Q28J95/107-203 OS Xenopus tropicalis #=GS Q28J95/107-203 DE Tetraspanin #=GS Q28J95/107-203 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana; Xenopus tropicalis; #=GS G1KKC7/108-208 AC G1KKC7 #=GS G1KKC7/108-208 OS Anolis carolinensis #=GS G1KKC7/108-208 DE Tetraspanin #=GS G1KKC7/108-208 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Lepidosauria; Squamata; Iguania; Dactyloidae; Anolis; Anolis carolinensis; #=GS W5ME63/11-105 AC W5ME63 #=GS W5ME63/11-105 OS Lepisosteus oculatus #=GS W5ME63/11-105 DE Uncharacterized protein #=GS W5ME63/11-105 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Actinopterygii; Actinopteri; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; Lepisosteus; Lepisosteus oculatus; #=GS B4HYS5/111-216 AC B4HYS5 #=GS B4HYS5/111-216 OS Drosophila sechellia #=GS B4HYS5/111-216 DE Tetraspanin #=GS B4HYS5/111-216 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila sechellia; #=GS B4Q7A9/111-216 AC B4Q7A9 #=GS B4Q7A9/111-216 OS Drosophila simulans #=GS B4Q7A9/111-216 DE Tetraspanin #=GS B4Q7A9/111-216 DR ORG; Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup; Drosophila simulans; #=GS H9G5S2/107-208 AC H9G5S2 #=GS H9G5S2/107-208 OS Anolis carolinensis #=GS H9G5S2/107-208 DE Uncharacterized protein #=GS H9G5S2/107-208 DR ORG; Eukaryota; Metazoa; Chordata; Craniata; Sarcopterygii; Lepidosauria; Squamata; Iguania; Dactyloidae; Anolis; Anolis carolinensis; #=GS A0A369SIH5/106-214 AC A0A369SIH5 #=GS A0A369SIH5/106-214 OS Trichoplax sp. H2 #=GS A0A369SIH5/106-214 DE Tetraspanin #=GS A0A369SIH5/106-214 DR ORG; Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax; Trichoplax sp. H2; #=GF SQ 32 Q9VLH0/111-216 --VMQSQVRGMLIRTMNQALAEY---EHDPY-VESGVDFMQSMLECCGVNEPEDWKDYLSANVN-----FTLGVDDVVVPNSCCGNQP---TSLNDSTQ-------MTCMETY-DYGCFRKMNFIVSQ- D6WNZ1/109-203 -FAYRNKLNEGFDKGLAQAMANY---RNDSTHIVADFDFMQETLHCCGNHGPEDWLNLT---------------PPYPIPLSCCINK----AKCDP----------GVKDQIF-SEGCYDKVFNFMNAN W4XEG4/110-212 -IAFKEEINTGIDNGLNNTMKHY---NEKEN-YQRSMDYVQGHLDCCGSHHAEDWATTPWG-----------HANPDMVPLSCCKDNA--TANCTGSLV-------NDQFNIN-HDGCQEKLYDDIKAY A7RNN8/98-200 -YVYRERIEKNLHGDIRSTMNEYH-LSGHDA-VTRAIDEIHRDFKCCGNAQYRDWFETKWA-----------KTHPDMVPRSCCKDPS--DSKCNENIS-------KDPTKIY-RRGCYMFVKKYLS-- A7SZN5/109-211 --IFRSEIKTGLSDGLDTALKDY---PEQG--FKDAWNDMQKNLKCCGSRNYTDWFMVAWAGP---------NTKNGSVPESCCKDTK--VKSCNLEVL-------SHPETINSEQGCYGAAVKYFED- B3RR47/104-210 --FFKSNISDFIGKDLENAIKNYD-THNDHG-IDRIVDKIQELFHCCGNHNYTDWSSSPFD-----------HVYPASVPDSCCKNRT---SGCGNDSLSLPRN--QAGEIIY-IEGCHDAIFNVAHD- T1FN76/114-208 --VYRDTIKRGFSEGMLLAMEEY---MEDPE-KQAAIDGIQSKLRCCGYNSHEDWSNYTIT------------HGHIPVPKSCCKVKK-----CDT----------TDPEAIY-VKGCFERVSAFMRSN E9FX18/112-200 --AYQDAIKESFKNGLKNSMKSY---KNVEA-NRDAVDTMQTALKCCGVESYEDWQDYG-----------------LPVPNSCCKAQT-----CNT----------KNPSSIN-EVGCYTTVVTFISS- Q7Q1S1/109-210 GYTQRDRMETEMESNLWLSVNQY---PVDVT-WQPYVDSYQMQLKCCGVHNYTDWLMAMPPDDITE---DDKDLIAQLVPLSCCDLAD--TAQC----------------TIY-DAGCHSKVYEIFYE- B3RLW6/106-214 -YVNRDLITTNLTSRLNSDLATY---YNTPT-TQTAFNTIQSGLSCCAVHNYTEWRGTSWYGNV-----SAVSTVTYPVPDSCCRSNVSDTASCGYTY--------STTNNIY-TTGCLAKLQTLASD- F6WHA2/112-197 -IISRNKINNGFEAGMQNAMKKY---KTDGA-YKTAVDNAQKTLHCCGSNNYTDYYTLP-------------GWNPNTVPMSCCSNL----TYCKEHL-------------VD-NKGCPQLV------- F6Z9C2/110-209 --CYQNELAQGFRAGLWQALWGY---GAGGR-EDASLDALQRGLGCCGVDTYRDWLDTPWARSP-------RAQGNGSLPPSCCQGQ----PDCQE-----------GARLVA-SDGCFSKASDFVADN C3YK57/120-219 ---FRGKLQDGFSDGLDKALAAYN-PAQDKN-QAKLVDDLQSQLKCCGKEQYSDWYKQPWA------------GGNNNVPLSCCKDQ----NKCVHQGLTN-----STTTDIY-TVGCYKLVVSAIN-- H3D1H6/106-221 --FYREDIAGGFRSGLQRAVAGY---TEDEG-RADALDSLQRALDCCGAEGWRDWLNSDWAVQHTT-FQTSENGSSVSLPDSCCVRR----KGCKNRPLMSDDNEGVAAAGIH-PHGCFRKVFSLVND- G1KW81/113-207 --LYRKDIAEGFQNGLWEAIRSY---TEDEG-KTEVLDAVQRSLNCCGVESYRDWFSSPWSME--------KPTPNSSVPMSCCRAR----KD---------------AWGIY-HDGCFTKISHFVSDN F7BE68/105-216 --FYRRDIAEGFQSGLQNAVQSY---AEDEE-KADALDDIQRALRCCGVHSYQDWFESPWSLEQLEQHQSFGEHSNNSVPSSCCQVR----RGCRNNPLL------PGAPGIH-WDGCFKKVCDFVSDN A0A369SE96/104-210 --FFKSNISDFIGKDLENAIKNYD-THNDHG-IDRIVDKIQELFHCCGNHNYTDWSSSPFD-----------HVYPASVPDSCCKNRT---SGCGNDSLSLPRN--QAGEIIY-IEGCHDAIFNVAHD- Q2TCS1/120-220 ---FRGKLQDGFSDGLDKALAAYN-PAQDKD-QAKLVDDLQSQLECCGKELYSDWYKQPWA------------GGNNNVPLSCCKDQ----NKCVHTGLTN-----STTSDIY-TVGCYKVVVNTINS- W5NMZ4/107-216 --FYRNDIAEGFRSGLHRAVAAY---GEDER-QADALDGLQRALECCGAEGWQDWLASPWAAE--------QAGGNRSVPTSCCVRR----RGCQNSPLPPGGAAAAAAAGIH-EHGCFRKVFDLVSDN H2MLK5/105-220 --FYREDIAGGFRSGLQRAVAGY---TEDEG-RADALDSLQRALECCGAEGWRDWLTSDWAIQHMT-FLPFENGTSVSLPDSCCVRR----KGCRNRPLLSDDSEGVAAAGIH-PHGCFRKVFSLVND- A0A3B3WEP5/107-222 --FYREDIAGGFRSGLHRAVAGY---TEDEG-RADALDSLQRALECCGAEGWRDWLNSDWAIQHMT-FLPAENGTSVSLPDSCCVRR----KGCRNRPLLSDDNDGVAAAGIH-PHGCFRKVFSLVND- A0A1L8GZ38/100-211 --FYRRDIAEGFQSGLQNAVQSY---AEDEE-KADVLDDIQRALRCCGVHSYRDWFESSWSLEQLEQHKFFGEHSNNSVPSSCCQVR----RGCRNNPVL------PGAPGIN-MDGCFKKVCDFVSEN A0A3B3IPM7/105-220 --FYREDIAGGFRSGLQRAVAGY---TEDEG-RADALDSLQRALECCGAEGWRDWLTSDWAIQHMT-FLPFENGTSVSLPDSCCVRR----KGCRNRPLLSDDSEGVAAAGIH-PHGCFRKVFSLVND- A0A3P9KTV0/108-223 --FYREDIAGGFRSGLQRAVAGY---TEDEG-RADALDSLQRALECCGAEGWRDWLTSDWAIQHMT-FLPFENGTSVSLPDSCCVRR----KGCRNRPLLSDDSEGVAAAGIH-PHGCFRKVFSLVND- Q4SA96/100-215 --FYREDIAGGFRSGLQRAVAGY---TEDEG-RADALDSLQRALDCCGAEGWRDWLNSDWAVQHTT-FQTSENGSSVSLPDSCCVRR----KGCKNRPLMSDDNEGVAAAGIH-PHGCFRKVFSLVND- Q28J95/107-203 ----VDKINPELEKNMDNLFKTY---NGVDV-SSSTVDFIQERLECCGRKNYTDWEETDWY------------QTNKSLPMSCCKKNA---QDCQRVI--------GQQKDIY-TEACEPKLENLIHQV G1KKC7/108-208 -YTYREKLHQTLLKDVLKTMDKY---SGELQ-ITKAVDSLQRQFQCCGAENYTDWLNTTFG------------SLSSSVPRSCCKVPV---ESCVTDLS-------KYPVGIN-QQGCVAKVKTWFGEH W5ME63/11-105 ---YRKGIHKSILDVYLKTLHSY---PTEPN-LKVPVDRLQKQFHCCGAVIYSDWFNTT---------------LRNAVPDSCCMKET---PHCGTSI--------NETTNIY-TQGCIDKIGSWIHEH B4HYS5/111-216 --VMQSQVRGMLIRTMNQALAEY---EHDPY-VESGVDFMQSMLECCGVNEPEDWKDYLSANVN-----ITLGVDDVVVPNSCCGNQP---KSLNDSTQ-------MTCMETY-DYGCFRKMNFIVSQ- B4Q7A9/111-216 --VMQSQVRGMLIRTMNQALAEY---EHDPY-VESGVDFMQSMLECCGVNEPEDWKDYLSANVN-----STLGVDDVVVPNSCCGNQP---TSLNDSTQ-------MTCMETY-DYGCFRKMNFIVSQ- H9G5S2/107-208 ---YSAEVESQLKNKMGPFFHKYNWTAPNHR-DTVYVDATHKKLKCCGISNYTDWMIMLPN---------HLQIGHGFAPESCCRETY---LDCRGDL--------SQPEKLF-KDGCHKKLEERFY-- A0A369SIH5/106-214 -YVNRDLITTNLTSRLNSDLATY---YNTPT-TQTAFNTIQSGLSCCAVHNYTEWRGTSWYGNV-----SAVSTVTYPVPDSCCRSNVSATASCGYTY--------STTNNIY-TTGCLAKLQTLASD- #=GC scorecons 002464363345345633554390003453302334583584374998344548833333301000000000222334693999334000033733221000000023323750338943552334330 #=GC scorecons_70 ____*__*_______*______*______________*__*__*_***_____**_______________________**_***_________*_________________*____**___________ #=GC scorecons_80 ______________________*______________*__*__*_***_____**________________________*_***___________________________*____**___________ #=GC scorecons_90 ______________________*______________*__*____***_____**________________________*_***________________________________**___________ //