The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: DNA-binding protein Fis

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
577 P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA)
(567 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
577 P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI)
(567 more)
Bacterial-type RNA polymerase core promoter sequence-specific DNA binding GO:0000985
Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a bacterial gene.
577 P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP)
(567 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
577 P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP)
(567 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
577 P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA)
(567 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
577 P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI)
(567 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
577 P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA)
(567 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
577 P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI)
(567 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
577 P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA)
(567 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
577 P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP)
(567 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
577 P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA)
(567 more)
Sequence-specific DNA binding, bending GO:0044374
The activity of binding selectively and non-covalently to DNA in a sequence-specific manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
577 P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP)
(567 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
96 P64127 (/ISS) P64127 (/ISS) P64127 (/ISS) P64127 (/ISS) P64127 (/ISS) P64127 (/ISS) P64127 (/ISS) P64127 (/ISS) P64127 (/ISS) P64127 (/ISS)
(86 more)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Bacterial transcription GO:0001121
The synthesis of RNA from a DNA template by a bacterial-type RNA polymerase, originating at a bacterial-type promoter.
577 P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP)
(567 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
577 P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA)
(567 more)
Response to radiation GO:0009314
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
577 P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP)
(567 more)
Provirus excision GO:0032359
The molecular events that lead to the excision of a viral genome from the host genome.
577 P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP)
(567 more)
Chromatin organization involved in regulation of transcription GO:0034401
Any cellular process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin that modulates the rate, frequency or extent of DNA-dependent transcription.
577 P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA)
(567 more)
Positive regulation of DNA recombination GO:0045911
Any process that activates or increases the frequency, rate or extent of DNA recombination.
577 P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP)
(567 more)
Single-species submerged biofilm formation GO:0090609
A process in which planktonically growing microorganisms of the same species aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
577 D3GYQ2 (/IMP) D3GYQ2 (/IMP) D3GYQ2 (/IMP) D3GYQ2 (/IMP) D3GYQ2 (/IMP) D3GYQ2 (/IMP) D3GYQ2 (/IMP) D3GYQ2 (/IMP) D3GYQ2 (/IMP) D3GYQ2 (/IMP)
(567 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
96 P64127 (/ISS) P64127 (/ISS) P64127 (/ISS) P64127 (/ISS) P64127 (/ISS) P64127 (/ISS) P64127 (/ISS) P64127 (/ISS) P64127 (/ISS) P64127 (/ISS)
(86 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
7 P57902 (/EXP) P57902 (/EXP) P57902 (/EXP) P57902 (/EXP) P57902 (/EXP) P57902 (/EXP) P57902 (/EXP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasmic nucleosome GO:0000787
A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the cytoplasm into higher order structures.
577 P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA)
(567 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
577 P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA)
(567 more)
Invertasome GO:0031421
A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts.
577 P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP) P0A6R3 (/IMP)
(567 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
577 P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA) P0A6R3 (/IDA)
(567 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
577 P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI) P0A6R3 (/IPI)
(567 more)