CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Serine/threonine-protein kinase pim-1

Enzyme Information
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P11309
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC and EC

UniProtKB Entries (1)

Homo sapiens
Serine/threonine-protein kinase pim-1

PDB Structure

External Links
Primary Citation
Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.
Wang, H.L., Andrews, K.L., Booker, S.K., Canon, J., Cee, V.J., Chavez Jr., F., Chen, Y., Eastwood, H., Guerrero, N., Herberich, B., Hickman, D., Lanman, B.A., Laszlo 3rd., J., Lee, M.R., Lipford, J.R., Mattson, B., Mohr, C., Nguyen, Y., Norman, M.H., Pettus, L.H., Powers, D., Reed, A.B., Rex, K., Sastri, C., Tamayo, N., Wang, P., Winston, J.T., Wu, B., Wu, Q., Wu, T., Wurz, R.P., Xu, Y., Zhou, Y., Tasker, A.S.
J. Med. Chem.