CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.530.10
Functional Family Endo-type membrane-bound lytic murein transglycosylase A

Enzyme Information

4.2.2.n2
Peptidoglycan lytic endotransglycosylase.
based on mapping to UniProt P0C960
Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.

UniProtKB Entries (1)

P0C960
EMTA_ECOLI
Escherichia coli K-12
Endo-type membrane-bound lytic murein transglycosylase A

PDB Structure

PDB 6GI4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli.
Dik, D.A., Batuecas, M.T., Lee, M., Mahasenan, K.V., Marous, D.R., Lastochkin, E., Fisher, J.F., Hermoso, J.A., Mobashery, S.
Biochemistry