CATH Classification

Domain Context

CATH Clusters

Superfamily Histone deacetylase domain
Functional Family Histone deacetylase

Enzyme Information

3.5.1.98
Histone deacetylase.
based on mapping to UniProt P56524
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
-!- A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on a histone. -!- The reaction of this enzyme is opposite to that of EC 2.3.1.48. -!- Histone deacetylases (HDACs) can be organized into three classes depending on sequence similarity and domain organization. -!- Histone acetylation plays an important role in regulation of gene expression. -!- In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. -!- May be identical to EC 3.5.1.17.

UniProtKB Entries (1)

P56524
HDAC4_HUMAN
Homo sapiens
Histone deacetylase 4

PDB Structure

PDB 6FYZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor.
Luckhurst, C.A., Aziz, O., Beaumont, V., Burli, R.W., Breccia, P., Maillard, M.C., Haughan, A.F., Lamers, M., Leonard, P., Matthews, K.L., Raphy, G., Stott, A.J., Munoz-Sanjuan, I., Thomas, B., Wall, M., Wishart, G., Yates, D., Dominguez, C.
Bioorg. Med. Chem. Lett.