CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.10 | Thrombin, subunit H |
|
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
| Superfamily | Trypsin-like serine proteases |
| Functional Family | Neutrophil elastase |
Enzyme Information
| 3.4.21.37 |
Leukocyte elastase.
based on mapping to UniProt P08246
Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.
-!- Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.7 and EC 3.4.21.11.
|
UniProtKB Entries (1)
| P08246 |
ELNE_HUMAN
Homo sapiens
Neutrophil elastase
|
PDB Structure
| PDB | 6F5M |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor.
Acta Crystallogr F Struct Biol Commun
|