CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Mitogen-activated protein kinase kinase kinase 5

Enzyme Information

2.7.11.25
Mitogen-activated protein kinase kinase kinase.
based on mapping to UniProt Q99683
ATP + a protein = ADP + a phosphoprotein.
-!- This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, but requires MAPKKKK for activation. -!- Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras. -!- While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway. -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q99683
M3K5_HUMAN
Homo sapiens
Mitogen-activated protein kinase kinase kinase 5

PDB Structure

PDB 6E2O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
ASK1 contributes to fibrosis and dysfunction in models of kidney disease.
Liles, J.T., Corkey, B.K., Notte, G.T., Budas, G.R., Lansdon, E.B., Hinojosa-Kirschenbaum, F., Badal, S.S., Lee, M., Schultz, B.E., Wise, S., Pendem, S., Graupe, M., Castonguay, L., Koch, K.A., Wong, M.H., Papalia, G.A., French, D.M., Sullivan, T., Huntzicker, E.G., Ma, F.Y., Nikolic-Paterson, D.J., Altuhaifi, T., Yang, H., Fogo, A.B., Breckenridge, D.G.
J. Clin. Invest.