1 keywords

CATH Domain 6b8oF00

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.60 Sandwich
Topology 2.60.40 Immunoglobulin-like
Homologous Superfamily 2.60.40.10 Immunoglobulins

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Triggering receptor expressed on myeloid cells 2

Enzyme Information

UniProtKB Entries (1)

Q9NZC2
TREM2_HUMAN
Homo sapiens
Triggering receptor expressed on myeloid cells 2

PDB Structure

PDB 6B8O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
Sudom, A., Talreja, S., Danao, J., Bragg, E., Kegel, R., Min, X., Richardson, J., Zhang, Z., Sharkov, N., Marcora, E., Thibault, S., Bradley, J., Wood, S., Lim, A.C., Chen, H., Wang, S., Foltz, I.N., Sambashivan, S., Wang, Z.
J. Biol. Chem.