CATH Classification

Domain Context

CATH Clusters

Superfamily PPM-type phosphatase domain
Functional Family Protein phosphatase 1A

Enzyme Information

3.1.3.16
Protein-serine/threonine phosphatase.
based on mapping to UniProt P35813
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (1)

P35813
PPM1A_HUMAN
Homo sapiens
Protein phosphatase 1A

PDB Structure

PDB 6B67
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A trapped human PPM1A-phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity.
Debnath, S., Kosek, D., Tagad, H.D., Durell, S.R., Appella, D.H., Acevedo, R., Grishaev, A., Dyda, F., Appella, E., Mazur, S.J.
J. Biol. Chem.